V. Lee

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Inhibitors of Bacterial Efflux Pumps as Adjuvants in Antibacterial Therapy and Diagnostic Tools for Detection of Resistance by Efflux

J. Pagés, F. Bambeke, V. Lee, 2010 .

Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux.

J. Pagés, F. Van Bambeke, V. Lee, 2006, Recent patents on anti-infective drug discovery.

Five-Membered Ring Systems: With More Than One N Atom

S. Lang, C. Ziegler, V. Lee, 1993 .

Synthesis of hydrazones and oximes of geldanaldehyde as potential polymerase inhibitors

K. Rinehart, F. Reusser, L. Li, 1977 .

Synthesis of 5,8‐dihydroxynaphtho[2,3‐c][1,2,5]thiadiazole‐6,9‐dione and 6,9‐dihydroxybenzo[g]quinoxaline‐5,10‐dione

R. Angier, J. Warren, V. Lee, 1979 .

Antibiotic resistance versus small molecules, the chemical evolution

V. Lee, S. Hecker, 1999, Medicinal research reviews.

Chapter 12 - Antimicrobial Potentiation Approaches: Targets and Inhibitors

T. Renau, S. Hecker, V. Lee, 1998 .

In Vivo Antibacterial Activity of RWJ-54428, a New Cephalosporin with Activity against Gram-Positive Bacteria

D. C. Griffith, M. Dudley, Robert Williams, 2003, Antimicrobial Agents and Chemotherapy.

Antibiotic resistance versus small molecules, the chemical evolution

V. Lee, S. Hecker, 1999, Medicinal research reviews.

Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.

C. Boojamra, S. Hecker, V. Lee, 2003, Bioorganic & medicinal chemistry letters.

What's new in the antibiotic pipeline.

M. Yagisawa, V. Lee, G. Miller, 1999, Current opinion in microbiology.

Structure-activity relationship, selectivity and mode of inhibition of terminal deoxyribonucleotidyltransferaseby streptolydigin analogs

K. Rinehart, R. Dicioccio, V. Lee, 1980 .

N-Linked solid phase peptide synthesis

S. Hecker, V. Lee, R. Yen, 1998 .

Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa.

T. Renau, R. Léger, O. Lomovskaya, 2002, Bioorganic & medicinal chemistry letters.

SYNTHESIS OF 5,8-DIHYDROXYNAPHTHO(2,3-C)(1,2,5)THIADIAZOLE-4,9-DIONE AND 6,9-DIHYDROXYBENZO(G)QUINOXALINE-5,10-DIONE

R. Angier, J. Warren, V. Lee, 1980 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate.

H. Nitanai, W. Watkins, K. Nakayama, 2007, Bioorganic & medicinal chemistry.

1.2 – Conjugate Additions of Reactive Carbanions to Activated Alkenes and Alkynes

V. Lee, 1991 .

7.02 – Bicyclic 5-5 Systems: Three Heteroatoms 1:2

V. Lee, 1996 .

Anti-Gram Positive Agents of Natural Product Origins

V. Lee, 2007 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model.

W. Watkins, K. Nakayama, K. Hoshino, 2004, Bioorganic & medicinal chemistry letters.

Conjugate Additions of Carbon Ligands to Activated Alkenes and Alkynes Mediated by Lewis Acids

V. Lee, 1991 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: exploration of aromatic substituents.

H. Nitanai, W. Watkins, K. Nakayama, 2006, Bioorganic & medicinal chemistry.

1,2,3-thiadiazoles. I. Synthesis of sodium (or potassium) 1,2,3-thiadiazole-4-thiolates via thiocarbazonate esters and N-acylthiohydrazonate esters

V. Lee, K. Learn, W. Curran, 1988 .

Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

S. Lang, K. Bush, S. Sakya, 1997 .

Patents (and patent applications) on β-lactam antibacterials: January 1995 - December 1998

V. Lee, 1999 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety.

W. Watkins, K. Nakayama, K. Hoshino, 2004, Bioorganic & medicinal chemistry letters.

MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization.

T. Renau, W. Watkins, K. Nakayama, 2003, Bioorganic & medicinal chemistry letters.

Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy

Angela Lee, M. Lee, M. S. Warren, 2001, Antimicrobial Agents and Chemotherapy.

7.10 – Bicyclic 5-6 Systems: Four Heteroatoms 3:1

V. Lee, 1996 .

Synthetic studies in unnatural cyclic amino acids

R. Woodward, V. Lee, 1979 .

THE SYNTHESIS OF METHYL 2-HYDROXY-5-METHOXY-3-METHYLBENZOATE

M. Newman, V. Lee, 1981 .

Formation of allenes on alkaline treatment of 3-nitroso-4,5,5-trialkyl-2-oxazolidones

M. Newman, V. Lee, 1973 .

Synthesis of Thieno[2,3-d]-1,3-dithiol-2-thiones from Thieno[2,3-d]-1,2,3-thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions†

U. Jordis, V. Lee, P. Boamah, 2002, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry.

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.

M. Dudley, T. Renau, W. Watkins, 2003, Bioorganic & medicinal chemistry letters.

, Jorge Agents for Combination Therapy : Novel Pseudomonas aeruginosa Pumps in Inhibitors of Multidrug Resistance Efflux Identification and Characterization of

Angela Lee, M. Lee, M. S. Warren, 2000 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.

T. Renau, W. Watkins, K. Nakayama, 2003, Bioorganic & medicinal chemistry letters.

Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa

Angela Lee, E. Boyer, M. S. Warren, 1999, Antimicrobial Agents and Chemotherapy.

Advances in tetracycline antibiotics

V. Lee, 1995 .

Review: Anti-infectives Advances in tetracycline antibiotics

V. Lee, 1995 .

Glycylcyclines. Part 1. A New Generation of Potent Antibacterial Agents Through Modification of 9-Aminotetracyclines.

J. Bloom, Y. Gluzman, F. Tally, 1994 .

Synthesis of novel tetracycline derivatives with substitution at the C-8 position

F. Tally, P. Sum, V. Lee, 1994 .

A novel reagent for regioselective cleavage of 2,3-epoxyalcohols by fluoride - a synthesis of 3-fluoro-293-dideoxy-d-erythro-pentose.

S. Lang, B. Arshava, V. Lee, 1992 .

Synthesis and crystal structure of 3′-fluoro-3′-methyl-2′,3′-dideoxythymidine. inhibitory properties of 3′-fluoro-3′-methyl-2′,3′-dideoxythymidine-5′-triphosphate in the synthesis of DNA in cell-free media

A. Shutalev, G. Gurskaya, V. Zavodnik, 1994 .

Synthesis of 3-substituted (azido, acylthio, chloro or fluoro)-2,3-dideoxy-D-erythro-pentoses and 3-methyl-3-substituted-2,3-dideoxy-D-erythro-pentoses

S. Lang, B. Arshava, V. Lee, 1994 .

A Novel Reagent for Regioselective Cleavage of 2,3‐Epoxy Alcohols by Fluoride. A Synthesis of 3‐Fluoro‐2,3‐dideoxy‐D‐erythro‐pentose.

S. Lang, B. Arshava, V. Lee, 1993 .

Effect of A(1,3)-cis strain on the asymmetric epoxidation of (E)- and (Z)-6,6-diethoxy-3-hexen-2-ols and 4-methyl-6,6-diethoxy-3-hexen-2-ols

S. Lang, V. Shvets, B. Arshava, 1998 .

Synthesis of 3‐Substituted (Azido, Acylthio, Chloro or Fluoro)‐2,3‐ dideoxy‐D‐erythro‐pentoses and 3‐Methyl‐3‐substituted‐2,3‐dideoxy‐D‐ erythro‐pentoses.

S. Lang, B. Arshava, V. Lee, 1994 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position.

W. Watkins, K. Nakayama, K. Hoshino, 2006, Bioorganic & medicinal chemistry.

Effect of A(1,3)-cis Strain on the Asymmetric Epoxidation of (E)- and (Z)-6,6-Diethoxy-3-hexen-2-ols and 4-Methyl-6,6-diethoxy-3-hexen-2-ols.

S. Lang, V. Shvets, B. Arshava, 1999 .

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases.

S. Benkovic, K. R. Maples, Rajeshwar Singh, 2006, Bioorganic & medicinal chemistry letters.

Biowarfare Pathogens. Is the Research Flavor Different Than That of Clinically Relevant Pathogens?

V. Lee, 2004, Annual Reports in Medicinal Chemistry.

Acyl tetramic acids. 6. Synthesis of 3-dienoyl tetramic acids related to streptolydigin and tirandamycin

K. Rinehart, V. Lee, T. Herrin, 1978 .

Pyrido(3,4-e)-1,2,4-triazines and Related Heterocycles as Potential Antifungal Agents.

M. Reich, P. Fabio, R. Testa, 1989 .

Improved procedures for ethynylcarbinol hydration and oxime reduction to amino alcohols

M. Newman, V. Lee, 1975 .

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.

T. Renau, K. Nakayama, S. Hecker, 1999, Journal of medicinal chemistry.

Synthetic Studies of Analogues of Streptolydigin, Tirandamycin and Related Compounds

V. Lee, 1975 .

3-acyl tetramic acids. 7. Synthesis of 3-acyl tetramic acids via aspartimide rearrangement

K. Rinehart, V. Lee, D. Cartwright, 1978 .

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

K. Bush, Youjun Yang, B. Rasmussen, 1993, Antimicrobial Agents and Chemotherapy.

Improved synthesis of 3-methylphthalic anhydride

M. Newman, V. Lee, 1977 .