T. Purohit

发表

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

Craig W. Lindsley, Shaun R. Stauffer, Jolanta Grembecka, 2014, Journal of medicinal chemistry.

Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.

T. Cierpicki, J. Grembecka, Łukasz Berlicki, 2020, European journal of medicinal chemistry.

Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes

T. Cierpicki, J. Grembecka, G. Lund, 2015, Journal of medicinal chemistry.

Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts

T. Quan, Z. Qin, T. Purohit, 2017, PloS one.

Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging.

J. Voorhees, T. Quan, T. He, 2016, Journal of dermatological science.

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

Jolanta Grembecka, Thomas Hartley, J. Hess, 2012, Nature chemical biology.

Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules

T. Cierpicki, J. Grembecka, S. Kłossowski, 2017, MedChemComm.

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.

J. Voorhees, Sewon Kang, T. Quan, 2009, The American journal of pathology.

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

P. González-Alonso, F. Gray, T. Cierpicki, 2021, Nature Chemical Biology.

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma

Z. Nwosu, T. Cierpicki, J. Grembecka, 2021, Molecular Cancer Research.

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations.

T. Cierpicki, J. Grembecka, S. Kłossowski, 2020, Blood.

Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.

T. Cierpicki, J. Grembecka, S. Kłossowski, 2018, Journal of medicinal chemistry.

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Bo Wen, Jolanta Grembecka, Hongzhi Miao, 2015, Cancer cell.

The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.

J. Hess, T. Cierpicki, J. Grembecka, 2014, Blood.

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Maksymilian Chruszcz, Jolanta Grembecka, Thomas Hartley, 2012, Blood.

Covalent inhibition of NSD1 histone methyltransferase

A. Ferrando, M. Sulis, P. González-Alonso, 2020, Nature Chemical Biology.

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

O. Abdel-Wahab, Y. Dou, T. Cierpicki, 2019, The Journal of clinical investigation.

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML with activating FLT3 mutations.

T. Cierpicki, J. Grembecka, S. Kłossowski, 2020, Blood.

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).

T. Cierpicki, J. Grembecka, Ting Zhao, 2016, Journal of medicinal chemistry.

The same site on LEDGF IBD domain represents therapeutic target for MLL leukemia and HIV

J. Hess, T. Cierpicki, J. Grembecka, 2014 .

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner

S. Malek, T. Cierpicki, J. Grembecka, 2016, Leukemia.

Abstract 3225: LEDGF IBD domain represents therapeutic target for MLL leukemia and HIV

J. Hess, T. Cierpicki, J. Grembecka, 2014 .

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Y. Dou, T. Cierpicki, J. Grembecka, 2021, Nature Communications.