J. Iegre

发表

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Organic & biomolecular chemistry.

Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data

R. A. Thompson, M. A. Hayes, E. Isin, 2016, Drug Metabolism and Disposition.

A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action

A. Venkitaraman, M. Hyvönen, C. De Fusco, 2022, RSC Medicinal Chemistry.

Second-generation CK2α inhibitors targeting the αD pocket† †Electronic supplementary information (ESI) available: All experimental details, crystallographic data collection and refinement statistics, details of chemical synthesis, additional figures and tables. See DOI: 10.1039/c7sc05122k

D. Spring, P. Brear, M. Rossmann, 2018, Chemical science.

Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future

D. Spring, M. Hyvönen, N. Robertson, 2018, Advanced Therapeutics.

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Stephen J. Walsh, D. Spring, L. Itzhaki, 2019, Chemical communications.

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

D. Spring, M. Hyvönen, A. North, 2018, Bioorganic & medicinal chemistry.

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

D. Spring, P. Brear, M. Hyvönen, 2021, Molecules.

Chemical probes targeting the kinase CK2: a journey outside the catalytic box.

D. Spring, P. Brear, M. Hyvönen, 2021, Organic & biomolecular chemistry.

Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs).

D. Spring, J. Iegre, Daniel H. O’ Donovan, 2020, Chemical Society reviews.

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

David R. Spring, Marko Hyvönen, D. Spring, 2017, Bioorganic & medicinal chemistry.

Second-generation CK2 alpha inhibitors targeting the alpha D pocket.

D. Spring, M. Rossmann, M. Hyvönen, 2018 .

Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface.

D. Spring, M. Hyvönen, A. North, 2018 .

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

J. Katzenellenbogen, K. Carlson, Xiaozhuo Chen, 2015, ChemMedChem.

Stapled peptides as a new technology to investigate protein–protein interactions in human platelets

D. Spring, Y. S. Tan, C. Verma, 2018, Chemical science.

Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design

Christian Tyrchan, Christoph Grebner, Anders Hogner, 2016, J. Chem. Inf. Model..

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

Xiaozhuo Chen, T. Tuccinardi, A. Martinelli, 2013, Bioorganic & medicinal chemistry letters.