G. Clarke

发表

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.

G. Hardy, T. Skarzynski, O. Singh, 2001, Bioorganic & medicinal chemistry letters.

Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992, Journal of medicinal chemistry.

Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.

G. Dondio, M. Sbacchi, V. Vecchietti, 1994, Journal of medicinal chemistry.

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.

A. Giordani, V. Vecchietti, G. Clarke, 1991, Journal of medicinal chemistry.

5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.

P. Nambi, C. Parini, S. Gagliardi, 1998, Journal of medicinal chemistry.

Evaluation of the potassium channel activator BRL 38227 as an inhaled bronchodilator in the guinea-pig: contrast with nifedipine and salbutamol.

J. Arch, G. Clarke, D. Buckle, 1991, Pulmonary pharmacology.

Central and peripheral analgesic agents: chemical strategies for limiting brain penetration in kappa-opioid agonists belonging to different chemical classes.

M. Sbacchi, V. Vecchietti, G. Clarke, 1995, Farmaco.

Inhibition of mammalian 5-lipoxygenase by 2-benzylaminophenols.

K. Foster, G. Clarke, D. Buckle, 1988, Prostaglandins, leukotrienes, and essential fatty acids.

Comparison of the water diuretic activity of kappa receptor agonists and a vasopressin receptor antagonist in dogs.

D. Brooks, M. Sbacchi, G. Clarke, 1997, The Journal of pharmacology and experimental therapeutics.

Potent and selective non-peptidic delta opioid ligands based on the novel heterocycle-condensed octahydroisoquinoline structure

G. Dondio, P. Petrillo, V. Vecchietti, 1994, Regulatory Peptides.

Comparative effects of selective kappa-opioid receptor agonists on dopamine levels in the dorsal caudate of freely moving rats.

P. Zaratin, G. Clarke, 1994, European journal of pharmacology.

Contribution of alpha-2 adrenoceptors to kappa opioid agonist-induced water diuresis in the rat.

D. Brooks, M. Sbacchi, G. Clarke, 1994, The Journal of pharmacology and experimental therapeutics.

4,5-Functionalized 6-Phenyl-3(2H)-pyridazinones: Synthesis and Evaluation of Antinociceptive Activity.

V. D. Piaz, M. Giovannoni, D. Barlocco, 1996 .

4,5-Functionalized 6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity

V. D. Piaz, M. Giovannoni, D. Barlocco, 1996 .

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.

G. Hardy, D. Belton, T. Skarzynski, 2001, Bioorganic & medicinal chemistry letters.

A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology.

Martin R. Johnson, S. Hodgson, S. Walls, 1999, The Journal of organic chemistry.

Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in the guinea‐pig: comparison with nifedipine

J. Arch, J. Arch, G. Clarke, 1988, British journal of pharmacology.

Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice.

Lisa Godfrey, Ian Kitchen, Luo Yan, 2006, European journal of pharmacology.

NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats

M. Raiteri, G. Bonanno, P. Zaratin, 2000, Neuropharmacology.

An investigation of binding sites for paracetamol in the mouse brain and spinal cord.

I. Kitchen, S. Hourani, G. Clarke, 2005, European journal of pharmacology.

Synthesis and structure-activity relationships of bafilomycin A1 derivatives as inhibitors of vacuolar H+-ATPase.

S. Gagliardi, P. Gatti, C. Farina, 1998, Journal of medicinal chemistry.

Deletion of the adenosine A2A receptor in mice enhances spinal cord neurochemical responses to an inflammatory nociceptive stimulus

C. Ledent, S. Hourani, I. Kitchen, 2012, Neuroscience Letters.

Genetic deletion of the adenosine A2A receptor in mice reduces the changes in spinal cord NMDA receptor binding and glucose uptake caused by a nociceptive stimulus

C. Ledent, S. Hourani, I. Kitchen, 2010, Neuroscience Letters.

Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice

Geoffrey D. Clarke, Ian Kitchen, C. Ledent, 2007, PAIN.

Substituted 1-(Aminomethyl)-2-(arylacetyl)-1,2,3,4- tetrahydroisoquinolines: A Novel Class of Very Potent Antinociceptive Agents with Varying Degrees of Selectivity for and μ Opioid Receptors.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992 .

BRL 22321, a compound that has mast cell stabilizing activity similar to that of disodium cromoglycate and in addition has smooth muscle relaxing activity

G. Clarke, J. Ross, H. Smith, 1983, Agents and Actions.

Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).

Martin R. Johnson, G. Hardy, A. Wonacott, 2002, Journal of medicinal chemistry.

Effects of highly selective κ-opioid agonists on EEG power spectra and behavioural correlates in conscious rats

C. Campi, G. Clarke, 1995, Pharmacology Biochemistry and Behavior.

Enantiospecificity of kappa receptors: comparison of racemic compounds and active enantiomers in two novel series of kappa agonist analgesics.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992, Chirality.

Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.

S Ronzoni, G. Dondio, M. Artico, 1997, Journal of medicinal chemistry.

Paracetamol inhibits nitric oxide synthesis in murine spinal cord slices.

I. Kitchen, Ian Bailey, S. Hourani, 2007, European journal of pharmacology.

Synthesis, Biological Evaluation, and Quantitative Receptor Docking Simulations of 2‐((Acylamino)ethyl)‐1,4‐benzodiazepines as Novel Tifluadom‐Like Ligands with High Affinity and Selectivity for ϰ‐ Opioid Receptors.

M. Menziani, A. Cappelli, M. Anzini, 1996 .

Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.

M. Menziani, P. D. De Benedetti, A. Cappelli, 1996, Journal of medicinal chemistry.

(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.

M. Sbacchi, V. Vecchietti, G. Clarke, 1991, Journal of medicinal chemistry.

THE ROLE OF THE “SPACER" IN THE OCTAHYDROISOQUINOLINE SERIES: DISCOVERY OF SB 213698, A NON-PEPTIDIC, POTENT AND SELECTIVE DELTA OPIOID AGONIST

G. Dondio, P. Petrillo, V. Vecchietti, 1995 .

Antinociceptive effects of non-steroidal anti-inflammatory drugs in a rat model of unilateral hindpaw inflammation.

G. Clarke, I. Macpherson, R. Spangler, 1994, European journal of pharmacology.