T. Ishida

发表

Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cells

Shigeo Mori, Toshiki Watanabe, Y. Morishita, 2002, Oncogene.

CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth.

J. Inoue, T. Yamamoto, S. Ishida, 1995, Journal of immunology.

The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphoma.

Toshiki Watanabe, M. Kadin, M. Higashihara, 2004, Cancer cell.

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

J. Inoue, J. Gohda, Kazuo Suzuki, 2018, Scientific Reports.

Catechin, green tea component, causes caspase‐independent necrosis‐like cell death in chronic myelogenous leukemia

S. Adachi, Toshiki Watanabe, Yuko Sato, 2009, Cancer science.

Transient inhibition of NF‐κB by DHMEQ induces cell death of primary effusion lymphoma without HHV‐8 reactivation

K. Nakano, K. Umezawa, Toshiki Watanabe, 2009, Cancer science.

Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ.

N. Yamamoto, K. Umezawa, Toshiki Watanabe, 2008, Microbes and infection.

In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia.

K. Yamaguchi, K. Umezawa, Toshiki Watanabe, 2005, Carcinogenesis.

Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells.

Toshiki Watanabe, M. Kadin, M. Higashihara, 2002, The American journal of pathology.

Rapid tumor death model for evaluation of new therapeutic agents for adult T-cell leukemia

K. Yamaguchi, Toshiki Watanabe, T. Ohsugi, 2004, Laboratory Investigation.

SMYD3 interacts with HTLV‐1 Tax and regulates subcellular localization of Tax

Yusuke Nakamura, Y. Furukawa, K. Nakano, 2011, Cancer science.

Expression screening of 17q12–21 amplicon reveals GRB7 as an ERBB2‐dependent oncogene

K. Semba, Shinya Watanabe, M. Saito, 2012, FEBS letters.

In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.

K. Yamaguchi, K. Umezawa, Toshiki Watanabe, 2006, Leukemia research.

5 (cid:2) -Long Terminal Repeat-Selective CpG Methylation of Latent Human T-Cell Leukemia Virus Type 1 Provirus In Vitro and In Vivo

K. Yamaguchi, S. Kamihira, Toshiki Watanabe, 2002 .

Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication.

K. Nakano, Yuetsu Tanaka, Toshiki Watanabe, 2013, Microbes and infection.

Collaboration with China

Y. Kawaoka, A. Iwamoto, Z. Matsuda, 2014 .

Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

J. Inoue, K. Kato, M. Hirai, 1998, Gene.

A novel domain in the CD 30 cytoplasmic tail mediates NF κ B activation

J. Inoue, Toshiki Watanabe, M. Higashihara, 1998 .

Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines.

K. Yamaguchi, S. Okada, K. Umezawa, 2007, Cancer letters.

Development of an Ultrasensitive HIV-1 DNA Detection Assay Based on an Automated πCode End-Point PCR System

Kazuo Suzuki, Zhixin Liu, John Zaunders, 2019 .

Latent HIV-1 reactivation in transgenic mice requires cell cycle -dependent demethylation of CREB/ATF sites in the LTR

Y. Iwakura, J. Yasuda, T. Watanabe, 2003, AIDS.

Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China

G. Gao, J. Gohda, Jing Xie, 2015, PloS one.

Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells

D. Cooper, A. Kelleher, Kazuo Suzuki, 2011, Nucleic acids research.

Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.

K. Yamaguchi, K. Uozumi, A. Utsunomiya, 2005, Blood.

Epigenetic repression of interleukin 2 expression in senescent CD4+ T cells during chronic HIV type 1 infection.

A. Iwamoto, M. Koga, A. Kawana-Tachikawa, 2015, The Journal of infectious diseases.

Inhibition of active HIV-1 replication by NF-kappaB inhibitor DHMEQ.

K. Umezawa, Toshiki Watanabe, A. Miyake, 2010, Microbes and infection.

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific

D. Cooper, A. Kelleher, D. Murray, 2011, RNA biology.

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

D. Cooper, A. Kelleher, Kazuo Suzuki, 2008, Journal of Biological Chemistry.

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region*

E. Kieff, J. Inoue, G. Mosialos, 1996, The Journal of Biological Chemistry.

Bioimaging analysis of nuclear factor‐κB activity in Philadelphia chromosome‐positive acute lymphoblastic leukemia cells reveals its synergistic upregulation by tumor necrosis factor‐α‐stimulated changes to the microenvironment

K. Umezawa, Toshiki Watanabe, A. Tojo, 2011, Cancer science.

Tumor Necrosis Factor Receptor-associated Factor (TRAF) 5 and TRAF2 Are Involved in CD30-mediated NFκB Activation*

Ko Okumura, Hideo Yagita, J. Inoue, 1997, The Journal of Biological Chemistry.

Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription.

D. Cooper, A. Kelleher, Kazuo Suzuki, 2009, Microbes and infection.

HIV-1 viral blips are associated with repeated and increasingly high levels of cell-associated HIV-1 RNA transcriptional activity

B. Brew, J. Zaunders, Kazuo Suzuki, 2021, AIDS.

Epigenetic Heterogeneity in HIV-1 Latency Establishment

Makoto Yamagishi, Toshiki Watanabe, Toshiki Watanabe, 2015, Scientific Reports.

5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals

Toshiki Watanabe, T. Ishida, T. Koiwa, 2006, Retrovirology.

HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period

K. Nakano, Toshiki Watanabe, T. Yamochi, 2012, Retrovirology.

5′-Long Terminal Repeat-Selective CpG Methylation of Latent Human T-Cell Leukemia Virus Type 1 Provirus In Vitro and In Vivo

K. Yamaguchi, S. Kamihira, Toshiki Watanabe, 2002, Journal of Virology.

A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages.

J. Inoue, T. Watanabe, M. Higashihara, 1996, Blood.

Development and Customization of a Color-Coded Microbeads-Based Assay for Drug Resistance in HIV-1 Reverse Transcriptase

G. Gao, W. Sugiura, L. Gu, 2014, PloS one.

Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing

D. Cooper, A. Kelleher, Kazuo Suzuki, 2013, Molecular therapy. Nucleic acids.

Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury

C. Rae, B. Brew, J. Zaunders, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Glycyrrhizin enhances interleukin‐12 production in peritoneal macrophages

H. Fujiwara, J. Dai, Y. Iwatani, 2001, Immunology.

Induction of interleukin‐12 p40 transcript by CD40 ligation via activation of nuclear factor‐xB

J. Inoue, H. Nariuchi, T. Yoshimoto, 1997, European journal of immunology.

Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis

K. Higashi, H. Yamamura, Y. Yamanashi, 1997, The Journal of experimental medicine.

Identification and characterization of Stathmin 1 as a host factor involved in HIV-1 latency.

J. Gohda, S. Yamaoka, H. Takeuchi, 2021, Biochemical and biophysical research communications.

HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus

K. Maeda, H. Takeuchi, Jumpei Ito, 2019, Scientific Reports.

p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein.

S. Okada, K. Umezawa, T. Shimasaki, 2013, Carcinogenesis.

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

J. Inoue, T. Yamamoto, T. Tojo, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Epigenetic alteration of the NF‐κB‐inducing kinase (NIK) gene is involved in enhanced NIK expression in basal‐like breast cancer

J. Inoue, K. Semba, Shinya Watanabe, 2010, Cancer science.

Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling.

J. Inoue, T. Yamamoto, S. Azuma, 2000, Experimental cell research.

A novel domain in the CD30 cytoplasmic tail mediates NFkappaB activation.

J. Inoue, T. Watanabe, M. Higashihara, 1998, International immunology.

A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis

R. Owens, D. Stuart, Yuan Chen, 2015, Scientific Reports.

Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.

W. Rom, S. Oka, S. Mori, 2007 .

SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR

M. Mochizuki, Yuetsu Tanaka, Toshiki Watanabe, 2006, Retrovirology.

Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma

K. Nakano, T. Hishima, S. Okada, 2015, Scientific Reports.

HIV-1 Subtype B/B′ and Baseline Drug Resistance Mutation Are Associated With Virologic Failure: A Multicenter Cohort Study in China

J. Xie, W. Lv, L. Gu, 2015, Journal of acquired immune deficiency syndromes.

CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission

J. Routy, W. Lv, L. Gu, 2014, AIDS.

TRAF activation of C/EBPbeta (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages.

Toshiki Watanabe, S. Kimura, A. Yoneyama, 2007, Microbes and infection.

5 ' long terminal repeat ( LTR )-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals

Toshiki Watanabe, T. Ishida, T. Koiwa, 2015 .

Epigenetic alteration of the NF‐κB‐inducing kinase (NIK) gene is involved in enhanced NIK expression in basal‐like breast cancer

J. Inoue, K. Semba, Shinya Watanabe, 2010, Cancer science.

HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro

J. Inoue, J. Gohda, A. Iwamoto, 2015, Retrovirology.