C. Dobrowolski

发表

A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.

J. Karn, J. Mellors, E. Acosta, 2020, Journal of Infectious Diseases.

Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis

J. Karn, A. F. Karim, Xuedong Ding, 2016, Scientific Reports.

Detecting Sources of Immune Activation and Viral Rebound in HIV Infection

J. Karn, Alon Herschhorn, D. Kaufmann, 2022, bioRxiv.

Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery

James E. Dahlman, P. Santangelo, Kalina Paunovska, 2022, Nature Nanotechnology.

Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery

James E. Dahlman, P. Santangelo, Kalina Paunovska, 2022, Nature Nanotechnology.

An HIV-induced mechanism for T cell quiescence and proviral latency

J. Karn, F. Niazi, K. Leskov, 2021 .

Reduction of the HIV-1 reservoir in T cells from persons with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells ex vivo

Michele D. Sobolewski, J. Karn, J. Mellors, 2022, bioRxiv.

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

J. Karn, P. Bacchetti, E. Scully, 2018, Proceedings of the National Academy of Sciences.

Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery.

James E. Dahlman, Kalina Paunovska, David Loughrey, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.

J. Karn, Xiaolan Yu, Abdel-Malek Shahir, 2015, Virology.

Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles

James E. Dahlman, Jared Beyersdorf, D. Vanover, 2022, Nature Nanotechnology.

Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells

J. Karn, M. Morales, Yun Wang, 2012, Journal of NeuroVirology.

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

J. Karn, G. Landreth, S. Valadkhan, 2016, Journal of NeuroVirology.

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

J. Karn, Won-Kyung Cho, C. Dobrowolski, 2021, bioRxiv.

Inhibition of the H3K27 demethylase UTX enhances the epigenetic 1 silencing of HIV proviruses and induces HIV-1 DNA hypermethylation

J. Karn, Won-Kyung Cho, C. Dobrowolski, 2021 .

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

M. Adams, J. Karn, K. Fujinaga, 2014, Molecular and Cellular Biology.

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

J. Karn, M. Chance, G. Gokulrangan, 2013, PLoS pathogens.

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

J. Karn, B. Das, C. Dobrowolski, 2017, mBio.

Therapeutic RNA Delivery for COVID and Other Diseases

James E. Dahlman, Kalina Paunovska, Melissa P. Lokugamage, 2021, Advanced healthcare materials.

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events

J. Karn, J. Tilton, Caroline O Tabler, 2014, Journal of Virology.

The histone deacetylase inhibitor vorinostat ( SAHA ) increases the susceptibility of uninfected 1 CD 4 + T cells to HIV by increasing the kinetics and efficiency of post-entry viral events 2 3

J. Karn, J. Tilton, Caroline O Tabler, 2014 .

The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells

J. Karn, Fengchun Ye, Nirmala Ramanath, 2018, Journal of Neuroimmune Pharmacology.

Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation

J. Karn, M. Altfeld, S. Lewin, 2018, The Journal of infectious diseases.

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

J. Karn, R. Rojas, B. Das, 2017, Retrovirology.

A Targeted Mass Spectrometry Assay for Detection of HIV Gag Protein Following Induction of Latent Viral Reservoirs.

M. Chance, D. Schlatzer, J. Tilton, 2017, Analytical chemistry.

Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation.

J. Karn, M. Altfeld, S. Lewin, 2018 .

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

J. Karn, R. Rojas, B. Das, 2017, Retrovirology.

Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery.

James E. Dahlman, Kalina Paunovska, A. Cristian, 2022, Nano letters.

Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial

J. Karn, J. Safrit, D. Douek, 2022, Nature Medicine.

Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery

James E. Dahlman, C. Zurla, P. Santangelo, 2023, Nature Chemistry.

The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo

James E. Dahlman, P. Santangelo, Kalina Paunovska, 2023, Nano letters.

The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells

J. Karn, Fengchun Ye, Nirmala Ramanath, 2018, Journal of Neuroimmune Pharmacology.

Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda

J. Karn, W. Boom, D. Winner, 2022, Retrovirology.

Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells

J. Karn, M. Morales, Yun Wang, 2012, Journal of NeuroVirology.

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

J. Karn, A. Telenti, A. Ciuffi, 2019, mBio.

A Reliable Primary Cell Model for HIV Latency: The QUECEL (Quiescent Effector Cell Latency) Method.

J. Karn, U. Mbonye, C. Dobrowolski, 2022, Methods in molecular biology.

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.

J. Karn, Xiaolan Yu, Abdel-Malek Shahir, 2015, Virology.

A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315).

J. Karn, J. Mellors, E. Acosta, 2020, The Journal of infectious diseases.