J. Daanen

发表

TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats

A. Gomtsyan, J. Segreti, Robert G. Schmidt, 2015, Temperature.

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.

A. Gomtsyan, Chih-Hung Lee, E. Bayburt, 2011, Bioorganic & medicinal chemistry letters.

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

A. Gomtsyan, P. Mantyh, J. Sullivan, 2009, Pain.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.

M. Nakane, J. Brioni, R. Moreland, 2005, Bioorganic & medicinal chemistry.

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.

Meena Patel, M. Nakane, J. Brioni, 2005, Journal of medicinal chemistry.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid-3 (TRPV3) Antagonist.

A. Gomtsyan, Robert G. Schmidt, P. Kym, 2016, The Journal of organic chemistry.

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.

Arianna Gelain, Daniela Barlocco, Lucio Toma, 2007, Journal of medicinal chemistry.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012 .

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.

D. Donnelly-roberts, S. Arneric, J. Sullivan, 1998, Bioorganic & medicinal chemistry letters.

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

S. Arneric, J. Sullivan, D. Garvey, 1999, Bioorganic & medicinal chemistry letters.

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.

W. J. Jackson, S. Arneric, J. Buccafusco, 1997, The Journal of pharmacology and experimental therapeutics.

ABT‐089 [3‐(2(S)‐pyrrolidinylmethoxy)‐2‐methyl‐pyridine]: An orally effective cholinergic channel modulator with potential once‐a‐day dosing and cardiovascular safety

S. Arneric, J. Sullivan, N. Lin, 1997 .

Gram scale synthesis of the glucuronide metabolite of ABT-724.

S. Wagaw, Kenneth M. Engstrom, A. Stewart, 2006, The Journal of organic chemistry.

Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.

M. Jarvis, C. Lee, K. Kohlhaas, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.

R. Henry, T. Dyhring, C. Surowy, 2006, Journal of medicinal chemistry.

Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1

A. King, P. Kym, M. Kort, 2012, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Journal of medicinal chemistry.

Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Journal of medicinal chemistry.

Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.

E. Kowaluk, J. Kerwin, M. Cowart, 1998, Journal of Medicinal Chemistry.

Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.

R. Gum, T. Neelands, M. Kort, 2016, Journal of medicinal chemistry.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of medicinal chemistry.