A. Hobeika

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Increasing vaccine potency through exosome antigen targeting.

J. Le Pecq, H. Lyerly, M. Morse, 2011, Vaccine.

Chapter 28 – Intracellular Cytokine Assays

H. Lyerly, M. Morse, P. Mosca, 2005 .

Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

K. Blackwell, H. Lyerly, M. Morse, 2011, Clinical Cancer Research.

A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC 1 Compared With the Same Poxvectors Plus GM-CSF for Resected Metastatic Colorectal Cancer

Anuradha, J. Marshall, D. Hsu, 2013 .

A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC1 Compared With the Same Poxvectors Plus GM-CSF for Resected Metastatic Colorectal Cancer

J. Marshall, D. Hsu, T. Crocenzi, 2013, Annals of surgery.

Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma

G. Hannon, Heather Geiger, N. Robine, 2022, Nature Communications.

In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior

Philip F. Hughes, B. Pogue, T. Haystead, 2017, Clinical Cancer Research.

Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors

Yanjie Zhao, H. Lyerly, J. Zhao, 2019, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects

D. Niedzwiecki, G. Devi, M. Morse, 2012, Cancer Immunology, Immunotherapy.

Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2

K. Blackwell, C. Anders, P. Marcom, 2007, Journal of Translational Medicine.

NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity

H. Lyerly, M. Morse, H. Lyerly, 2006, Cancer Immunology, Immunotherapy.

Functional CD3+CD8+PD1- T Cell Accumulation and PD-L1 Expression Increases During Tumor Invasion in DCIS of the Breast.

H. Lyerly, M. Morse, Jun Ren, 2019, Clinical breast cancer.

An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity

W. Barry, Dong-Wan Kim, N. Spector, 2010, Clinical Cancer Research.

Clinical efficacy of intra-cavitary infusions of autologous dendritic cell/cytokine-induced killer cell products for the treatment of refractory malignant pleural effusions and ascites.

H. Lyerly, M. Morse, Jun Ren, 2020 .

Clearance of Circulating Bacteria and Recovery of Microbiota Diversity Following Adoptive Cellular Therapy in Advanced Colorectal Cancer Patients

H. Lyerly, M. Morse, Jun Ren, 2020 .

Phase I clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion

K. Blackwell, N. Spector, X. Ren, 2012, Journal of Translational Medicine.

Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo

W. Barry, N. Spector, X. Ren, 2010, International journal of cancer.

Depletion of human regulatory T cells.

H. Lyerly, M. Morse, T. Osada, 2011, Methods in molecular biology.

Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.

M. Kulis, Songtao Li, D. Koeberl, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Immunotherapy with Autologous, Human Dendritic Cells Transfected with Carcinoembryonic Antigen mRNA

E. Gilboa, H. Hurwitz, J. Schlom, 2003, Cancer investigation.

Flt3-ligand as a Vaccine Adjuvant: Results in a Study of Flt3-ligand Plus Tetanus Toxoid Immunization

H. Lyerly, M. Morse, S. Chui, 2004 .

Active immunotherapy with Flt3-ligand mobilized peripheral blood dendritic cells loaded with carcinoembryonic antigen peptide in patients with metastatic malignancies

H. Lyerly, M. Morse, S. Chui, 2004 .

Enumerating Antigen-Specific T-Cell Responses in Peripheral Blood: A Comparison of Peptide MHC Tetramer, ELISpot, and Intracellular Cytokine Analysis

D. Niedzwiecki, H. Lyerly, M. Morse, 2005, Journal of immunotherapy.

Analysis of Cellular Immune Responses in Cancer Vaccine Trials

D. Niedzwiecki, H. Lyerly, M. Morse, 2004 .

Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand

H. Lyerly, M. Morse, P. Mosca, 2002, Journal of leukocyte biology.

Cancer Therapy: Clinical MHC Class I – Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer

K. Blackwell, A. Secord, M. Morse, 2011 .

Precision Cancer Immunotherapy: Optimizing Dendritic Cell-based Strategies to Induce Tumor Antigen-specific T-cell Responses Against Individual Patient Tumors

K. Choudhury, H. Lyerly, M. Morse, 2015, Journal of immunotherapy.

Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

K. Blackwell, N. Spector, X. Ren, 2012, Breast Cancer Research.

Zoledronic acid induces an immune response through increased central memory and effector memory gamma/delta T cells in early and metastatic breast cancer patients

K. Owzar, K. Blackwell, P. Marcom, 2015 .

HER2 dendritic cell vaccines.

H. Lyerly, M. Morse, M. Cheever, 2003, Clinical breast cancer.

Phase I Study of Immunizationwith Dendritic Cells Modifiedwith Fowlpox Encoding Carcinoembryonic Antigen and CostimulatoryMolecules

J. Schlom, D. Niedzwiecki, H. Lyerly, 2005 .

EDDR1 is a Potential Immunotherapeutic Antigen in Ovarian, Breast, and Prostate Cancer

A. Secord, P. Block, H. Lyerly, 2011 .

EDDR 1 is a Potential Immunotherapeutic Antigen in Ovarian , Breast , and Prostate Cancer

Secord, P. Block, H. Lyerly, 2011 .

Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells.

H. Johnson, B. Torres, S. Kominsky, 2000, Cancer research.

Novel recombinant alphaviral and adenoviral vectors for cancer immunotherapy.

H. Lyerly, M. Morse, T. Osada, 2012, Seminars in oncology.

Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen.

J. Soos, J. Schiffenbauer, H. Johnson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy

P. Agarwal, H. Lyerly, M. Morse, 2017, Oncoimmunology.

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

Philip F. Hughes, C. Acharya, H. Lyerly, 2022, Journal for ImmunoTherapy of Cancer.

Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients

Frank R. Jones, Elizabeth S. Gabitzsch, Joseph P. Balint, 2013, Cancer Immunology, Immunotherapy.

An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.

D. Niedzwiecki, H. Lyerly, G. Devi, 2010, The Journal of clinical investigation.

Phase I study of immunization with dendritic cells (DC) modified with recombinant fowlpox encoding carcinoembryonic antigen (CEA) and the triad of costimulatory molecules CD54, CD58, and CD80 (rF-CEA(6D)-TRICOM) in patients with advanced malignancies.

M. Morse, H. Lyerly, D. Panicali, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Biomarkers and correlative endpoints for immunotherapy trials.

H. Lyerly, M. Morse, S. Patel, 2013, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting.

IFNγ inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1

P. Subramaniam, H. Johnson, T. Tanabe, 1998, Oncogene.

Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.

H. Lyerly, Jun Ren, Yan-hua Yuan, 2018, Cytotherapy.

Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line

P. Cruz, P. Subramaniam, H. Johnson, 1998, Oncogene.

Superantigens: The Good, the Bad, and the Ugly

H. Johnson, S. Kominsky, A. Hobeika, 2001, Experimental biology and medicine.

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.

D. Niedzwiecki, H. Lyerly, M. Morse, 2008, Blood.

IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells

P. Subramaniam, H. Johnson, A. Hobeika, 1997, Oncogene.

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

J. Le Pecq, H. Lyerly, M. Morse, 2005, Journal of Translational Medicine.

The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion

H. Lyerly, M. Morse, Jun Ren, 2015, Oncotarget.

Vascular endothelial growth factor and immunosuppression in cancer: current knowledge and potential for new therapy

H. Lyerly, M. Morse, T. Clay, 2007, Expert opinion on biological therapy.

Blood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapy

H. Lyerly, M. Morse, Jun Ren, 2021, Oncoimmunology.

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

Philip F. Hughes, R. Nelson, L. Neckers, 2021, Molecular Cancer Therapeutics.

Creating a ‘Timeline’ of ductal carcinoma in situ to identify processes and biomarkers for progression towards invasive ductal carcinoma

G. Hannon, Heather Geiger, N. Robine, 2022, bioRxiv.

IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis.

P. Subramaniam, H. Johnson, B. Torres, 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Current immunotherapeutic strategies in colon cancer.

M. Morse, H. Lyerly, A. Starodub, 2007, Surgical oncology clinics of North America.

Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules

J. Schlom, D. Niedzwiecki, H. Lyerly, 2005, Clinical Cancer Research.

Phase I study of alphaviral vector (AVX701) in colorectal cancer patients: comparison of immune responses in stage III and stage IV patients

D. Niedzwiecki, M. Morse, H. Lyerly, 2015, Journal of Immunotherapy for Cancer.

Changes in peripheral blood regulatory T cells, and IL-6 and IL-10 levels predict response of pediatric medulloblastoma and germ cell tumors with residual or disseminated disease to craniospinal irradiation.

H. Lyerly, M. Morse, Linan Song, 2021, International journal of radiation oncology, biology, physics.

Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines

G. Devi, M. Morse, H. Kim Lyerly, 2011, Immunologic research.

Adoptive immunotherapy with autologous T cell infusions reduces opioid requirements in advanced cancer patients.

H. Lyerly, M. Morse, Jun Ren, 2019, Pain.

Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study

X. Yi, H. Lyerly, M. Morse, 2018, Clinical Cancer Research.

The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity.

P. Subramaniam, J. Soos, J. Schiffenbauer, 1995, Journal of immunology.

Superantigen enhanced protection against a weak tumor‐specific melanoma antigen: Implications for prophylactic vaccination against cancer

H. Johnson, B. Torres, S. Kominsky, 2001, International journal of cancer.

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study

K. Blackwell, T. Hyslop, P. Marcom, 2019, Clinical Cancer Research.

Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio

D. Hsu, D. Niedzwiecki, H. Lyerly, 2020, Journal for ImmunoTherapy of Cancer.

Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition

H. Lyerly, G. Broadwater, M. Morse, 2017, Oncoimmunology.

Recent developments in therapeutic cancer vaccines

H. Lyerly, M. Morse, S. Chui, 2005, Nature Clinical Practice Oncology.

MHC Class I–Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer

K. Blackwell, A. Secord, H. Lyerly, 2011, Clinical Cancer Research.

Predictive significance of T cell subset changes during ex vivo generation of adoptive cellular therapy products for the treatment of advanced non-small cell lung cancer

H. Lyerly, M. Morse, Jun Ren, 2019, Oncology letters.

Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC.

H. Lyerly, M. Morse, Jun Ren, 2020, American journal of cancer research.

Down-Regulation of neu/HER-2 by Interferon-γ in Prostate Cancer Cells

H. Johnson, B. Torres, S. Kominsky, 2000 .

Serial assessment of circulating T lymphocyte phenotype and receptor repertoire during treatment of non-muscle invasive bladder cancer with adoptive T cell immunotherapy.

Yanjie Zhao, H. Lyerly, M. Morse, 2020, American journal of cancer research.

Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth.

H. Lyerly, M. Morse, Jun Ren, 2019, Immunotherapy.

Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study

X. Yi, Yanjie Zhao, H. Lyerly, 2017, Clinical Cancer Research.

P1-13-03: Zoledronic Acid Induces an Immune Response in Breast Cancer Patients through Stimulation of Central Memory and Effector Memory gamma/delta T-Cells.

K. Owzar, P. Marcom, H. Lyerly, 2011 .

Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants.

H. Lyerly, M. Morse, D. Rizzieri, 2002, Journal of hematotherapy & stem cell research.

Effect of alphavirus vaccine encoding HER2 during concurrent anti-HER2 therapies on induction of oligoclonal T cell and antibody responses against HER2.

K. Blackwell, G. Broadwater, M. Morse, 2015 .

IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells.

P. Subramaniam, H. Johnson, A. Hobeika, 1997, Oncogene.

ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers

A. Secord, P. Block, H. Lyerly, 2011, Clinical and experimental immunology.

A neutralizing epitope of the superantigen SEA has agonist activity on T cells.

H. Johnson, A. Hobeika, 1996, Biochemical and biophysical research communications.

Prospective randomized comparative study on rivaroxaban and LMWH for prophylaxis of post-apheresis thrombosis in adoptive T cell immunotherapy cancer patients

Yanjie Zhao, H. Lyerly, M. Morse, 2019, Journal of Thrombosis and Thrombolysis.

Assays for monitoring cellular immune responses to active immunotherapy of cancer.

H. Lyerly, M. Morse, P. Mosca, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Clinical trials of self-replicating RNA-based cancer vaccines

M. Morse, Z. Hartman, H. Lyerly, 2023, Cancer Gene Therapy.

Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer.

D. Niedzwiecki, H. Lyerly, M. Morse, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Surrogate markers of response to cancer immunotherapy

H. Lyerly, M. Morse, P. Mosca, 2001, Expert opinion on biological therapy.

CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine

H. Lyerly, M. Morse, Jun Ren, 2018, Cancer Chemotherapy and Pharmacology.

Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody

D. Hsu, H. Lyerly, G. Devi, 2009, British Journal of Cancer.

Proteomics for monitoring immune responses to cancer vaccines.

H. Lyerly, M. Morse, P. Mosca, 2003, Current opinion in molecular therapeutics (Print).

A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment.

H. Lyerly, M. Morse, S. Nair, 2000, Blood.

Journal of Translational Medicine BioMed Central

J. Le Pecq, H. Lyerly, J. Garst, 2007 .

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study

K. Blackwell, T. Hyslop, P. Marcom, 2019, Clinical Cancer Research.

An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.

D. Niedzwiecki, G. Devi, H. Lyerly, 2010, The Journal of clinical investigation.

IFNγ induction of p21WAF1 in prostate cancer cells: Role in cell cycle, alteration of phenotype and invasive potential

P. Cruz, Wiguins Etienne, P. Subramaniam, 1998, International journal of cancer.

Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

K. Blackwell, H. Lyerly, M. Morse, 2011, Clinical Cancer Research.

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers

N. Spector, M. Morse, Z. Hartman, 2018, Breast Cancer Research.

Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients’ preference-based study (PPPS)

X. Zhou, X. Wang, H. Lyerly, 2018, Clinical and Translational Oncology.