T. Nemoto

发表

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.

H. Nagase, Shigeto Hirayama, H. Fujii, 2012, Bioorganic & medicinal chemistry.

Synthesis and evaluation of novel opioid ligands with a C-homomorphinan skeleton.

K. Nagai, Shigeto Hirayama, H. Fujii, 2016, Bioorganic & medicinal chemistry.

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2015, Bioorganic & medicinal chemistry letters.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

H. Nagase, T. Kanemasa, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry.

Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.

N. Yamaotsu, S. Hirono, H. Nagase, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2009, Bioorganic & medicinal chemistry.

Synthesis of novel twin drug consisting of 8-oxaendoethanotetrahydromorphides with a 1,4-dioxane spacer and its pharmacological activities: mu, kappa, and putative epsilon opioid receptor antagonists.

M. Narita, Tsutomu Suzuki, H. Nagase, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.

S. Hirono, H. Gouda, H. Nagase, 2009, Bioorganic & medicinal chemistry letters.

Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.

M. Narita, Tsutomu Suzuki, H. Nagase, 2008, Bioorganic & medicinal chemistry.

Synthesis of a novel 4,6′-epoxymorphinan derivative and a highly strained novel conjugated ketone

H. Nagase, N. Sato, H. Fujii, 2007 .

Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.

S. Hirono, H. Gouda, Shigeto Hirayama, 2014, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of (-)-homogalanthamine from naltrexone.

H. Tomoda, H. Nagase, J. Inokoshi, 2011, Journal of Organic Chemistry.

In vivo properties of KNT‐127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice

C. Gaveriaux-Ruff, B. Kieffer, H. Nagase, 2014, British journal of pharmacology.

Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies.

N. Yamaotsu, S. Hirono, H. Nagase, 2012, Chemical & pharmaceutical bulletin.

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

N. Wada, H. Nagase, Shigeto Hirayama, 2013, Bioorganic & medicinal chemistry letters.

Rearrangement of 4,5α-epoxymorphinan derivatives with carbamoylepoxy rings provide novel oxazatricyclodecane structures

H. Nagase, Shigeto Hirayama, H. Fujii, 2011 .

Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.

M. Narita, Tsutomu Suzuki, H. Nagase, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of a stable iminium salt and propellane derivatives.

S. Hirono, H. Nagase, K. Kamiya, 2008, The Journal of organic chemistry.

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & Medicinal Chemistry Letters.

Novel rearrangement reaction of a 6,14-endoethanomorphinan derivative to a benzomorphan derivative

H. Nagase, N. Sato, H. Fujii, 2009 .

Hydrogenolysis of the cyclopropyl group into an isopropyl group in the presence of a platinum catalyst and hydrobromic acid

H. Nagase, H. Fujii, T. Nemoto, 2009 .

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.

Investigation of Beckett-Casy model 3: synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology.

S. Hirono, H. Gouda, H. Nagase, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.

H. Nagase, Shigeto Hirayama, H. Fujii, 2012, Bioorganic & medicinal chemistry letters.

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

K. Wada, H. Nagase, A. Saitoh, 2011, Behavioural Brain Research.

Catalytic Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4,5-Epoxy Bridge Affords a More Selective Ligand for κ Opioid Receptor than the Representative κ Antagonist nor-BNI

H. Nagase, H. Mochizuki, H. Fujii, 2007 .

Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology.

H. Nagase, Satomi Imaide, Mayumi Nakajima, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

H. Nagase, H. Mochizuki, H. Fujii, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).

N. Wada, H. Nagase, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).

N. Wada, H. Nagase, Mayumi Nakajima, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.

N. Wada, H. Nagase, Shigeto Hirayama, 2014, ACS medicinal chemistry letters.

Synthesis of Novel Triplet Drugs with 1,3,5-Trioxazatriquinane Skeletons and Their Pharmacologies. Part 1. Synthesis of Triplet Drugs with Morphinan Skeletons.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2011 .

Synthesis of opioid ligands having oxabicyclo[2.2.2]octane and oxabicyclo[2.2.1]heptane skeletons

H. Nagase, K. Yoza, N. Sato, 2007 .

Discovery of δ Opioid Receptor Full Inverse Agonists and Their Effects on Restraint Stress-Induced Cognitive Impairment in Mice.

M. Tanabe, Shigeto Hirayama, H. Fujii, 2019, ACS chemical neuroscience.

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.

H. Nagase, Satomi Imaide, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry letters.

Novel cleavage reaction of the C16–N17 bond in naltrexone derivatives

H. Nagase, Satomi Imaide, H. Fujii, 2008 .

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

K. Wada, H. Nagase, A. Saitoh, 2011, Behavioural Brain Research.

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & medicinal chemistry letters.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2015, Bioorganic & medicinal chemistry letters.

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

H. Nagase, T. Kanemasa, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry.

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.