Chang Han

发表

Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis.

S. Dash, K. Song, Tong Wu, 2018, The American journal of pathology.

15-Hydroxyprostaglandin Dehydrogenase-derived 15-Keto-prostaglandin E2 Inhibits Cholangiocarcinoma Cell Growth through Interaction with Peroxisome Proliferator-activated Receptor-γ, SMAD2/3, and TAP63 Proteins*

D. Lu, Tong Wu, Chang Han, 2013, The Journal of Biological Chemistry.

Cytosolic phospholipase A2α and peroxisome proliferator‐activated receptor γ signaling pathway counteracts transforming growth factor β–mediated inhibition of primary and transformed hepatocyte growth

G. Michalopoulos, W. Bowen, A. Demetris, 2010, Hepatology.

MiR-122 in hepatitis B virus and hepatitis C virus dual infection.

S. Dash, K. Song, L. Balart, 2015, World journal of hepatology.

Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and cyclooxygenase-2

Miaoda Shen, Yifan Dai, K. Lim, 2009, Molecular Cancer Therapeutics.

TGFβ signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells

Tong Wu, Nathan A. Ungerleider, Chang Han, 2017, Molecular carcinogenesis.

15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1

D. Lu, Tong Wu, Chang Han, 2013, Oncogene.

Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids.

K. Isse, A. Demetris, K. Lim, 2008, Cancer research.

A novel positive feedback loop between peroxisome proliferator-activated receptor-δ and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.

K. Lim, Lihong Xu, Tong Wu, 2006, The Journal of Biological Chemistry.

Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

S. Dash, K. Lim, K. Song, 2016, Hepatology.

Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.

J. Shelhamer, Tong Wu, Chang Han, 2004, Cytokine.

Activation of NF-κB mediates the PMA-induced differentiation of K562 cells

Sun-Hee Kim, K. W. Kim, C. Kim, 1998 .

15-PGDH as A Therapeutic Target for Cholangiocarcinoma

Tong Wu, Chang Han, Lu Yao, 2015 .

Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury.

Tong Wu, Weina Chen, Chang Han, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury.

Tong Wu, Weina Chen, Chang Han, 2011, Journal of hepatology.

Cyclooxygenase‐2 prevents fas‐induced liver injury through up‐regulation of epidermal growth factor receptor

K. Isse, K. Lim, Lihong Xu, 2009, Hepatology.

Cyclooxygenase-2-derived Prostaglandin E2 Promotes Human Cholangiocarcinoma Cell Growth and Invasion through EP1 Receptor-mediated Activation of the Epidermal Growth Factor Receptor and Akt*

Tong Wu, Chang Han, 2005, Journal of Biological Chemistry.

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

Tong Wu, Chang Han, 2015, The Journal of Biological Chemistry.

Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells

G. Michalopoulos, Tong Wu, Chang Han, 2006, Journal of cellular physiology.

ACTIVATION OF CYTOSOLIC PHOSPHOLIPASE A2[alpha] THROUGH NITRIC OXIDE‐INDUCED S‐NITROSYLATION: INVOLVEMENT OF INDUCIBLE NITRIC OXIDE SYNTHASE AND CYCLOOXYGENASE‐2

K. Lim, Lihong Xu, Tong Wu, 2008, The Journal of biological chemistry.

Transgenic Expression of Cyclooxygenase-2 in Hepatocytes Accelerates Endotoxin-Induced Acute Liver Failure1

C. Gandhi, M. Defrances, K. Lim, 2008, The Journal of Immunology.

Endotoxin-Induced Acute Liver Failure in Hepatocytes Accelerates Transgenic Expression of Cyclooxygenase-2

C. Gandhi, M. Defrances, K. Lim, 2008 .

Yes‐Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis

C. Gandhi, S. Dash, K. Song, 2020, Hepatology.

miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor.

K. Song, Tong Wu, Weina Chen, 2015, The American journal of pathology.

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

Tong Wu, Chang Han, 2015, The Journal of biological chemistry.

85-kDa cPLA2 plays a critical role in PPAR-mediated gene transcription in human hepatoma cells

J. Shelhamer, G. Michalopoulos, A. Demetris, 2002 .

A Transforming Growth Factor‐β and H19 Signaling Axis in Tumor‐Initiating Hepatocytes That Regulates Hepatic Carcinogenesis

K. Song, Tong Wu, Weina Chen, 2018, Hepatology.

The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells

K. Song, Tong Wu, Weina Chen, 2020, PloS one.

Epigenetic regulation of MicroRNA‐122 by peroxisome proliferator activated receptor‐gamma and hepatitis b virus X protein in hepatocellular carcinoma cells

S. Dash, M. Feitelson, D. Lu, 2013, Hepatology.

MiR-17-92 cluster promotes hepatocarcinogenesis.

Tong Wu, Hanqing Zhu, Chang Han, 2015, Carcinogenesis.

Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression.

K. Lim, K. Song, Tong Wu, 2015, Cancer research.

ω-3 Polyunsaturated Fatty Acids Upregulate the Expression of 15-PGDH by Inhibiting miR-26 a and miR-26 b in Human Cholangiocarcinoma Cells

K. Lim, K. Song, Tong Wu, 2015 .

Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells

Tong Wu, Ying Wang, Chang Han, 2013, Hepatology.

miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT

K. Song, Tong Wu, Weina Chen, 2015, PloS one.

Transforming growth factor-β (TGF-β) activates cytosolic phospholipase A2α (cPLA2α)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated-γ (PPAR-γ)/Smad signaling pathways in human liver cancer cells. A NOVEL MECHANISM FOR SUBVERSION OF TGF-β-INDUCED MITOINHIBITION.

J. Shelhamer, Youhua Liu, A. Demetris, 2004, The Journal of Biological Chemistry.

Transforming Growth Factor-β (TGF-β) Activates Cytosolic Phospholipase A2α (cPLA2α)-mediated Prostaglandin E2 (PGE)2/EP1 and Peroxisome Proliferator-activated Receptor-γ (PPAR-γ)/Smad Signaling Pathways in Human Liver Cancer Cells

J. Shelhamer, Youhua Liu, A. Demetris, 2004, Journal of Biological Chemistry.

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122

S. Dash, K. Lim, K. Song, 2015, Oncotarget.

MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin.

Tong Wu, Chang Han, Jinqiang Zhang, 2012, Gastroenterology.

Modulation of Stat3 activation by the cytosolic phospholipase A2α and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway.

D. Stolz, A. Demetris, K. Lim, 2006, The Journal of Biological Chemistry.

Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

Soyeon Jeong, W. Yoon, S. Park, 2011, Autophagy.

miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway.

D. Lu, Tong Wu, Chang Han, 2014, The American journal of pathology.

Microsomal prostaglandin E synthase-1 (mPGES-1) promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis

Tong Wu, Dongdong Lu, D. Lu, 2011, Oncogene.

Regulation of Wnt/β‐catenin pathway by cPLA2α and PPARδ

K. Lim, Lihong Xu, Tong Wu, 2008, Journal of cellular biochemistry.

miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.

D. Lu, Hanqing Zhu, Tong Wu, 2014, The American journal of pathology.

Cyclooxygenase-2 Promotes Human Cholangiocarcinoma Growth

A. Demetris, J. Leng, Tong Wu, 2004, Cancer Research.

Modulation of Stat3 Activation by the Cytosolic Phospholipase A2α and Cyclooxygenase-2-controlled Prostaglandin E2 Signaling Pathway*

D. Stolz, A. Demetris, K. Lim, 2006, Journal of Biological Chemistry.

Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1.

K. Song, Tong Wu, Weina Chen, 2015, The American journal of pathology.

EZH2 Promotes Cholangiocarcinoma Development and Progression through Histone Methylation and microRNA-Mediated Down-Regulation of Tumor Suppressor Genes.

K. Song, Tong Wu, Weina Chen, 2022, The American journal of pathology.

The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis Through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway

K. Song, Tong Wu, Weina Chen, 2020, Hepatology.

Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway.

K. Song, Tong Wu, Weina Chen, 2017, The American journal of pathology.

Cyclooxygenase‐2 promotes hepatocellular carcinoma cell growth through AKT activation: Evidence for AKT inhibition in celecoxib‐induced apoptosis

G. Michalopoulos, J. Leng, Tong Wu, 2003, Hepatology.

miR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth

Tong Wu, Ying Wang, Chang Han, 2014, Molecular Cancer Research.

GASTROINTESTINAL , HEPATOBILIARY , AND PANCREATIC PATHOLOGY miR-101 Inhibits Cholangiocarcinoma Angiogenesis through Targeting Vascular Endothelial Growth Factor ( VEGF )

Tong Wu, Hanqing Zhu, K. Song, 2013 .

The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells.

A. Demetris, J. Leng, Tong Wu, 2004, Molecular cancer therapeutics.

Epigenetic regulation of miR‐122 by PPARgammar and hepatitis B virus X protein in hepatocellular carcinoma cells

K. Song, Tong Wu, Chang Han, 2013 .

PPARγ ligands inhibit cholangiocarcinoma cell growth through p53‐dependent GADD45 and p21WAF1/Cip1 pathway

J. Shelhamer, Q. Zhan, G. Michalopoulos, 2003, Hepatology.

PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway.

J. Shelhamer, Q. Zhan, G. Michalopoulos, 2003, Hepatology.

Involvement of 85‐kd cytosolic phospholipase A2 and cyclooxygenase‐2 in the proliferation of human cholangiocarcinoma cells

J. Shelhamer, G. Michalopoulos, J. Lunz, 2002, Hepatology.

Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma.

K. Song, Tong Wu, Weina Chen, 2021, Molecular Cancer Research.

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury

C. Gandhi, K. Lim, K. Song, 2017, PloS one.

85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells.

J. Shelhamer, G. Michalopoulos, A. Demetris, 2002, American journal of physiology. Gastrointestinal and liver physiology.

Alpha‐1 adrenergic receptor transactivates signal transducer and activator of transcription‐3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes

G. Michalopoulos, W. Bowen, Tong Wu, 2008, Journal of cellular physiology.

Prostaglandin E2 Receptor EP1 Transactivates EGFR/MET Receptor Tyrosine Kinases and Enhances Invasiveness in Human Hepatocellular Carcinoma Cells

G. Michalopoulos, Tong Wu, Chang Han, 2015, Journal of cellular physiology.

The role of cyclooxygenase‐2 in the development of steatohepatitis

Lihong Xu, Tong Wu, Chang Han, 2009 .

A Novel Positive Feedback Loop between Peroxisome Proliferator-activated Receptor-δ and Prostaglandin E2 Signaling Pathways for Human Cholangiocarcinoma Cell Growth*

Lihong Xu, Tong Wu, Chang Han, 2006, Journal of Biological Chemistry.

Activation of cytosolic phospholipase A2α through nitric oxide-induced S-nitrosylation. INVOLVEMENT OF INDUCIBLE NITRIC-OXIDE SYNTHASE AND CYCLOOXYGENASE-2.

K. Lim, Lihong Xu, Tong Wu, 2008, The Journal of Biological Chemistry.

Cross-talk between Peroxisome Proliferator-Activated Receptor δ and Cytosolic Phospholipase A2α/Cyclooxygenase-2/Prostaglandin E2 Signaling Pathways in Human Hepatocellular Carcinoma Cells

K. Lim, Lihong Xu, Tong Wu, 2006 .

Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells.

K. Lim, Lihong Xu, Tong Wu, 2006, Cancer research.

85-kDa Cytosolic Phospholipase A2 Mediates Peroxisome Proliferator-activated Receptor γ Activation in Human Lung Epithelial Cells*

J. Shelhamer, A. Demetris, R. Pawliczak, 2002, The Journal of Biological Chemistry.

Abstract 949: Epigenetic silencing of microRNA-34a promotes cholangiocarcinoma growth by regulating Notch pathway

K. Song, Tong Wu, Jinqing Zhang, 2016 .

Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma

E. Flemington, S. Dash, K. Moroz, 2016, Oncotarget.

Cyclooxygenase‐2 promotes hepatocellular carcinoma cell growth through AKT activation: Evidence for AKT inhibition in celecoxib‐induced apoptosis

G. Michalopoulos, J. Leng, Tong Wu, 2003, Hepatology.

The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway

K. Song, Tong Wu, Weina Chen, 2020, The FASEB Journal.

Activation of Cytosolic Phospholipase A2α through Nitric Oxide-induced S-Nitrosylation

K. Lim, Lihong Xu, Tong Wu, 2008, Journal of Biological Chemistry.

K. Lim, Lihong Xu, Tong Wu, 2006, Cancer research.

Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. A novel mechanism for subversion of TGF-beta-i

J. Shelhamer, Youhua Liu, Tong Wu, 2004, Journal of Biological Chemistry.

Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

S. Dash, K. Lim, K. Song, 2016, Hepatology.

G. Michalopoulos, W. Bowen, A. Demetris, 2010, Hepatology.

miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF).

Hanqing Zhu, Chang Han, Jinqiang Zhang, 2013, The American journal of pathology.

Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression.

K. Lim, K. Song, Tong Wu, 2015, Cancer research.

TUMORIGENESIS AND NEOPLASTIC PROGRESSION miR-185 Inhibits Hepatocellular Carcinoma Growth by Targeting the DNMT1/PTEN/Akt Pathway

Chang Han, Jinqiang Zhang, X. Qadir, 2022 .

15-Hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins.

D. Lu, Tong Wu, Chang Han, 2015, The Journal of Biological Chemistry.

Original Articles: Liver Biology and PathobiologyPPARγ ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21WAF1/Cip1 pathway☆

Q. Zhan, Tong Wu, Chang Han, 2003 .