M. Hoffmann

发表

Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo

M. Scheiner, M. Decker, P. Maher, 2020, Chemistry.

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

G. Adolf, C. Haslinger, D. Rudolph, 2009, Clinical Cancer Research.

BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells

J. Swantek, A. Schnapp, D. White, 2016, The Journal of Pharmacology and Experimental Therapeutics.

The laccase gene family in Coprinopsis cinerea (Coprinus cinereus)

S. Kilaru, P. Hoegger, U. Kües, 2004, Current Genetics.

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

T. Hoffmann, S. Schilling, H. Demuth, 2004, FEBS letters.

Competition of deprotonation and tin-lithium exchange in the generation of a glycosyl dianion

H. Kessler, M. Hoffmann, 1997 .

Inhibiteurs de la PI3 kinase

A. Pautsch, F. Kalkbrenner, Steffen Breitfelder, 2005 .

STEREOSELECTIVE SYNTHESIS OF A C-GLYCOSIDIC ANALOG OF N-GLUCOASPARAGINE

H. Kessler, M. Hoffmann, F. Burkhart, 1997 .

STEREOSELECTIVE SYNTHESIS OF A C-GLYCOSIDIC ANALOG OF N-GLUCOASPARAGINE

H. Kessler, M. Hoffmann, F. Burkhart, 1997 .

C‐Glycoside Analogues of N4‐(2‐Acetamido‐2‐deoxy‐β‐D‐glucopyranosyl)‐L‐asparagine: Synthesis and conformational analysis of a cyclic C‐glycopeptide

G. Hessler, H. Kessler, M. Hoffmann, 1996 .

A stereoselective synthesis of 2-acetamido-2-deoxy-C-glucosides: Glycosyl dianions as key intermediates

H. Kessler, M. Hoffmann, 1994 .

On the Regioselectivity and Stereoselectivity of the Carbene Transfer from Fischer Carbene Complexes to Trisubstituted Electron‐Deficient 1,3‐Dienes

H. Reissig, M. Buchert, M. Hoffmann, 1995 .

A Michael Equilibration Model To Control Site Selectivity in the Condensation toward Aminopyrazoles.

C. Senanayake, J. Mulder, Yuwen Wang, 2015, Organic letters.

Self-Regeneration of Stereocenters (SRS)—Applications, Limitations, and Abandonment of a Synthetic Principle†‡

D. Seebach, M. Hoffmann, A. R. Sting, 1996 .

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.

M. Scheiner, C. Sotriffer, M. Decker, 2019, Journal of medicinal chemistry.

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study.

M. Bartolini, M. Bolognesi, M. Decker, 2020, Bioorganic chemistry.

(R)‐ Tonkafuranone and related compounds: Improved synthesis, stereochemical purity in nature, and bioactivities of the pure enantiomers

M. Decker, G. Bringmann, M. Hoffmann, 2019, Flavour and Fragrance Journal.

Model studies of the reduction of 3‐phenyl‐6H‐1,2‐oxazines, chemo‐ and stereoselectivity: synthesis of amino alcohols, amino acids, and related compounds

H. Reissig, M. Hoffmann, R. Zimmer, 1992 .

Preparation and Use in Amino Acid Synthesis of a New Chiral Glycine Derivative – (R)‐ and (S)‐tert‐Butyl 2‐tert‐Butyl‐4‐methoxy‐2,5‐dihydroimidazole‐1‐carboxylate (BDI)☆

D. Seebach, M. Hoffmann, 1998 .

New Surprises with Fischer Carbene Complexes: Formal [3+2] Cycloadditions with and without Preeceding Carben–Ligand Matathesis

H. Reissig, M. Buchert, M. Hoffmann, 1997 .

Preparation and Transmetallation of a Triphenylstannyl β-D-Glucopyranoside: A highly stereoselective route to β-D-C-glycosides via glycosyl dianions

A. Vasella, H. Kessler, V. Wittmann, 1994 .

C-glycosides: A stereoselective synthesis of α- and β-C-galactosides with glycosyl dianions

H. Kessler, M. Hoffmann, Fred Burkhart, 1998 .

A Stereoselective Synthesis of 2‐Acetamido‐2‐deoxy‐C‐glucosides: Glycosyl Dianions as Key Intermediates.

H. Kessler, M. Hoffmann, 1995 .

Stereoselective Syntheses of Retro‐Isomers of N‐Glucoasparagine

H. Kessler, M. Hoffmann, O. Frey, 1995 .

Reduction of Ketones with LiAlH 4 Complexes of α,α,α',α'-Tetraaryl-1,3-dioxolane-4,5-dimethanols (TADDOLs) A Combination of Enantioselective Reduction and Clathrate Formation with a Discussion of LAH Reagents Bearing C 2 -Symmetrical Ligands

D. Seebach, A. Beck, M. Hoffmann, 1996 .

Separation of (R)- and (S)-tert-butyl 2-tert-butyl-4-methoxy-2,5-dihydro-1,3-imidazole-1-carboxylate (building block for amino acid synthesis) by preparative high performance liquid chromatography on a polysaccharide stationary phase

D. Seebach, M. Hoffmann, E. Küsters, 1998 .

Chromatographic resolution of synthetically useful chiral glycine derivatives by high-performance liquid chromatography

D. Seebach, M. Schulte, M. Hoffmann, 1998 .

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Péter Lénárt, Wolfgang J. Rettig, Jan-Michael Peters, 2007, Current Biology.

The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

J. Peters, N. Kraut, P. Lénárt, 2007, Current Biology.

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

P. Cohen, G. Sapkota, F. Newell, 2007, The Biochemical journal.

BI-D 1870 is a specific inhibitor of the p 90 RSK ( ribosomal S 6 kinase ) isoforms in vitro and in vivo

P. Cohen, G. Sapkota, F. Newell, 2006 .

Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.

M. Bartolini, Dominik Dolles, M. Scheiner, 2019, Journal of medicinal chemistry.

18F‐Labeled Derivatives of Irbesartan for Angiotensin II Receptor PET Imaging

M. Decker, H. Kimura, T. Higuchi, 2018, ChemMedChem.

Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.

M. Scheiner, C. Sotriffer, M. Decker, 2021, Journal of medicinal chemistry.

BI-D 1870 is a specific inhibitor of the p 90 Ribosomal S 6 Kinase ( RSK ) isoforms in vitro and in vivo

P. Cohen, G. Sapkota, F. Newell, 2006 .

7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

M. Decker, P. Maher, T. Maurice, 2019, Redox biology.

Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model.

M. Scheiner, M. Decker, A. Chatonnet, 2021, Journal of medicinal chemistry.

chrysomallus Streptomyces Cell-Bound Esterase from Molecular Analysis of a Gene Encoding a

U. Keller, M. Hoffmann, R. Berger, 1998 .

Synthesis and Initial Characterization of a Selective, Pseudo‐irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer

M. Decker, T. Higuchi, N. Nose, 2021, ChemMedChem.

Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.

Dominik Dolles, Hans-Joachim Wittmann, A. Strasser, 2018, Journal of medicinal chemistry.