G. Ainslie

发表

Bimodal substrate inhibition of lactate dehydrogenase. Factors affecting the enzyme in vivo.

W. Cleland, W. Ray, J. Burgner, 1978, Biochemistry.

mTOR Inhibition Mitigates Molecular and Biochemical Alterations of Vigabatrin-Induced Visual Field Toxicity in Mice.

J. Wisor, Michelle A. Schmidt, K. Gibson, 2017, Pediatric neurology.

Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.

G. Salomons, E. Jansen, K. Gibson, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity.

N. Oberlies, M. Paine, G. Ainslie, 2014, Journal of pharmaceutical and biomedical analysis.

Targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) employing an enzymatic assay for γ-hydroxybutyric acid (GHB) in biofluids

G. Salomons, E. Jansen, K. Gibson, 2016, Molecular genetics and metabolism reports.

Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Michelle A. Schmidt, G. Salomons, E. Jansen, 2019, Pharmacology research & perspectives.

Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis

T. Vanderah, N. Cherrington, M. Paine, 2015, The Journal of Pharmacology and Experimental Therapeutics.

The effect of oligomeric environment on the kinetics of lactate dehydrogenase subunits.

W. Cleland, G. Ainslie, 1982, Archives of biochemistry and biophysics.

Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2 −/− mice

Brian R. Phillips, T. Bottiglieri, D. Shen, 2015, Molecular genetics and metabolism reports.

Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues

T. Bottiglieri, Michelle A. Schmidt, E. Arning, 2019, Neurochemistry International.

Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug

D. Boykin, D. Thakker, M. Paine, 2013, Drug Metabolism and Disposition.

Transients and cooperativity. A slow transition model for relating transients and cooperative kinetics of enzymes.

K. Neet, G. Ainslie, J. Shill, 1972, The Journal of biological chemistry.

Cooperativity and slow transitions in the regulation of oligomeric and monomeric enzymes

K. Neet, G. Ainslie, 1976 .

[8] Hysteretic enzymes

K. Neet, G. Ainslie, 1980 .

Cooperativity and the slow isomerization of δ-chymotrypsin

K. Neet, G. Ainslie, 1979, Molecular and Cellular Biochemistry.

Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse

G. Salomons, E. Jansen, K. Gibson, 2015, Annals of clinical and translational neurology.

mTOR, Autophagy, Aminoacidopathies, and Human Genetic Disorders

K. Gibson, G. Ainslie, K. Vogel, 2016 .

A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS‐382 in mouse informs novel therapeutic strategies for the treatment of GHB intoxication

K. Gibson, G. Ainslie, K. Vogel, 2016, Pharmacology research & perspectives.

Assessment of a Candidate Marker Constituent Predictive of a Dietary Substance–Drug Interaction: Case Study with Grapefruit Juice and CYP3A4 Drug Substrates

M. Paine, K. K. Wolf, J. Hull, 2014, The Journal of Pharmacology and Experimental Therapeutics.

A Translational Approach to Assess the Risk of Dietary Substance-Drug Interactions

G. Ainslie, 2015 .

Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

P. Malaspina, P. Pearl, J. Roullet, 2016, Neurochemistry International.

Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

I. Rusyn, I. Pogribny, R. Bataller, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Conformational changes and association of chemically modified chymotrypsins.

K. Neet, G. Ainslie, L. Barritt, 1974, Archives of biochemistry and biophysics.

In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells

G. Salomons, E. Jansen, J. Roullet, 2017, PloS one.

Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies

A. Rotenberg, S. Dhamne, J. Roullet, 2018, Journal of Inherited Metabolic Disease.

mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

K. Gibson, G. Ainslie, K. Vogel, 2016, Journal of Inherited Metabolic Disease.

Hysteretic enzymes.

K. Neet, G. Ainslie, 1980, Methods in enzymology.

Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective.

Myrtle Davis, Lorna Ewart, Andrew J Thorley, 2019, Lab on a chip.

Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder.

J. Roullet, K. Gibson, G. Ainslie, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding.

J. Roullet, K. Gibson, G. Ainslie, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

I. Rusyn, I. Pogribny, R. Bataller, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity.

N. Oberlies, M. Paine, G. Ainslie, 2014, Journal of pharmaceutical and biomedical analysis.

Gamma-Hydroxybutyrate (GHB) Content in Hair Samples Correlates Negatively with Age in Succinic Semialdehyde Dehydrogenase Deficiency.

P. Pearl, S. Johansen, J. Roullet, 2017, JIMD reports.