A. Argyrou

发表

Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid

Matthew W Vetting, Argyrides Argyrou, J. Blanchard, 2006, Nature Structural &Molecular Biology.

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.

David M. Wilson, Fiona Pachl, S. Fawell, 2019, Cell chemical biology.

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.

G. Besra, J. Mckinney, N. Dhar, 2015, ACS infectious diseases.

Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.

S. Tentarelli, M. Vázquez‐Chantada, E. Chiarparin, 2021, Journal of medicinal chemistry.

Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry

Melanie V. Leveridge, Stuart M. Baddeley, C. Chung, 2012, Journal of biomolecular screening.

The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU

L. D. de Carvalho, M. Rejžek, R. Field, 2018, Biochemistry.

Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine.

J. Blanchard, L. D. de Carvalho, A. Argyrou, 2005, Journal of the American Chemical Society.

Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B

L. D. de Carvalho, L. Masino, Holly L. Douglas, 2021, Biochemistry.

Kinetic Evidence for Inter-Domain Communication in the Allosteric Regulation of α-Isopropylmalate Synthase from M. tuberculosis†

L. Carvalho, A. Argyrou, P. Frantom, 2009 .

Kinetic and mechanistic analysis of the Escherichia coli ribD-encoded bifunctional deaminase-reductase involved in riboflavin biosynthesis.

S. Cahill, J. Blanchard, A. Argyrou, 2008, Biochemistry.

Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes.

J. Blanchard, A. Argyrou, 2001, Biochemistry.

Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase.

Argyrides Argyrou, J. Blanchard, John S Blanchard, 2004, Biochemistry.

Flavoprotein disulfide reductases: advances in chemistry and function.

J. Blanchard, A. Argyrou, 2004, Progress in nucleic acid research and molecular biology.

Characterization of a New Member of the Flavoprotein Disulfide Reductase Family of Enzymes from Mycobacterium tuberculosis*

J. Blanchard, M. Vetting, A. Argyrou, 2004, Journal of Biological Chemistry.

Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase

B. Beno, J. Marcinkeviciene, L. Abell, 2014, The Journal of Biological Chemistry.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, G. Drewes, 2016, Nature Communications.

Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.

R. Angeletti, J. Blanchard, Lianji Jin, 2006, Biochemistry.

Insight Into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib Through Enzyme Kinetic Studies.

R. Ward, P. Doig, Richard T Ward, 2020, Biochemistry.

Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry

D. Mole, J. Liddle, I. Uings, 2014, Journal of biomolecular screening.

Mycobacterium tuberculosis Decaprenylphosphoryl-β-D-ribose Oxidase inhibitors: expeditious reconstruction of sub-optimal hits into a series with potent in vivo activity.

I. Wall, G. Burley, M. Cacho, 2020, Journal of medicinal chemistry.

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.

Christophe M. L. Vande Velde, Robert H Bates, Fraser Cunningham, 2018, Journal of medicinal chemistry.

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis

T. Ioerger, C. Nathan, M. Luo, 2016, Proceedings of the National Academy of Sciences.

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1

Robert H Bates, G. Besra, C. Chung, 2018, Scientific Reports.

Dihydroorotate dehydrogenase from Clostridium oroticum is a class 1B enzyme and utilizes a concerted mechanism of catalysis.

C. Pickart, M. Washabaugh, A. Argyrou, 2000, Biochemistry.

Demonstrating Enhanced Throughput of RapidFire Mass Spectrometry through Multiplexing Using the JmjD2d Demethylase as a Model System

Peter Francis, Andy West, Melanie Leveridge, 2014, Journal of biomolecular screening.

The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis.

J. Blanchard, B. Palfey, A. Argyrou, 2002, Biochemistry.

Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.

J. Blanchard, A. Argyrou, P. Frantom, 2009, Biochemistry.

University of Birmingham Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, G. Drewes, 2016 .

Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR

E. Evertsson, J. Kettle, A. Argyrou, 2024, ACS Medicinal Chemistry Letters.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, M. Bantscheff, 2016, Nature Communications.

New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.

Matthew W Vetting, Argyrides Argyrou, J. Blanchard, 2007, Journal of the American Chemical Society.