Qingfei Zheng

发表

Insight into bicyclic thiopeptide biosynthesis benefited from development of a uniform approach for molecular engineering and production improvement

Wen Liu, Yihua Yu, Heng Guo, 2014 .

Concurrent modifications of the C-terminus and side ring of thiostrepton and their synergistic effects with respect to improving antibacterial activities

Wen Liu, Yunsong Yu, Jianfeng Wang, 2016 .

Reversible histone glycation is associated with disease-related changes in chromatin architecture

Nathaniel D. Omans, S. Chandarlapaty, Shixin Liu, 2019, Nature Communications.

Thiopeptide Antibiotics act on both Host and Microbe to Deliver Double Punch on Mycobacterial Infection

Wen Liu, Qingfei Zheng, 2016 .

An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization

Wen Liu, Panpan Duan, Shoufeng Wang, 2016, Proceedings of the National Academy of Sciences.

Molecular engineering of thiostrepton via single “base”-based mutagenesis to generate side ring-derived variants

Wen Liu, Zhi Lin, Panpan Duan, 2016 .

Precursor-Directed Mutational Biosynthesis Facilitates the Functional Assignment of Two Cytochromes P450 in Thiostrepton Biosynthesis.

Wen Liu, Shoufeng Wang, Rijing Liao, 2016, ACS chemical biology.

Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe.

Q. Gao, Wen Liu, Shoufeng Wang, 2015, Chemistry & biology.

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.

J. Chen, I. Abe, Daozhong Zhang, 2013, Angewandte Chemie.

Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis

Wen Liu, Shoufeng Wang, Qingfei Zheng, 2014 .

Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics.

Wen Liu, H. Fang, Qingfei Zheng, 2017, Organic & biomolecular chemistry.

Insights into the thioamidation of thiopeptins to enhance the understanding of the biosynthetic logic of thioamide-containing thiopeptides.

Wen Liu, Zhi Lin, Dandan Chen, 2019, Organic & biomolecular chemistry.

A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions

Wen Liu, Hongbo Wang, Z. Tian, 2023, Nature Chemistry.

Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4.

Hualiang Jiang, Huaiyu Yang, Linlin Yang, 2016, Cell chemical biology.

Chemo-enzymatic synthesis of equisetin.

Wen Liu, Shuanhu Gao, Qingfei Zheng, 2017, Chemical communications.

Recent advances in understanding the enzymatic reactions of [4+2] cycloaddition and spiroketalization.

Zhenhua Tian, Wen Liu, Qingfei Zheng, 2016, Current opinion in chemical biology.

An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins.

Zhenhua Tian, A. Mándi, T. Kurtán, 2015, Nature chemical biology.

A linear hydroxymethyl tetramate undergoes an acetylation-elimination process for exocyclic methylene formation in the biosynthetic pathway of pyrroindomycins.

Zhenhua Tian, Wen Liu, P. Sun, 2016, Organic & biomolecular chemistry.

Non-enzymatic covalent modifications: a new link between metabolism and epigenetics

Yael David, Qingfei Zheng, I. Maksimovic, 2020, Protein & Cell.

Non-enzymatic covalent modifications: a new link between metabolism and epigenetics

Yael David, Qingfei Zheng, I. Maksimovic, 2020, Protein & Cell.

Nature-inspired protein ligation and its applications

Yael David, Qingfei Zheng, Rasmus Pihl, 2023, Nature Reviews Chemistry.

(De)Toxifying the Epigenetic Code.

Nicholas A. Prescott, Yael David, Qingfei Zheng, 2019, Chemical research in toxicology.

Chemical Labeling and Enrichment of Histone Glyoxal Adducts.

J. Galligan, Yael David, E. Jennings, 2022, ACS chemical biology.

Deglycase-activity oriented screening to identify DJ-1 inhibitors.

M. Michino, D. Huggins, Shan Sun, 2021, RSC medicinal chemistry.

An Azidoribose Probe to Track Ketoamine Adducts in Histone Ribose Glycation.

J. Galligan, Yael David, Qingfei Zheng, 2020, Journal of the American Chemical Society.

Synthesis of an Alkynyl Methylglyoxal Probe to Investigate Non-enzymatic Histone Glycation.

Yael David, Qingfei Zheng, I. Maksimovic, 2019, The Journal of organic chemistry.

Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation

Yael David, Qingfei Zheng, Adewola Osunsade, 2019, bioRxiv.

Reversible histone glycation is associated with disease-related changes in chromatin architecture

Nathaniel D. Omans, S. Chandarlapaty, Shixin Liu, 2019, Nature Communications.

Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis.

Wen Liu, Dandan Chen, Zhixiong Zhao, 2018, Cell chemical biology.

Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis.

I. Abe, Wen Liu, Takahiro Mori, 2015, Angewandte Chemie.

Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties

Renxiao Wang, Wen Liu, Yunsong Yu, 2015 .

Utilizing intein trans-splicing for in vivo generation of site-specifically modified proteins.

Yael David, Qingfei Zheng, I. Maksimovic, 2019, Methods in enzymology.

Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity

H. Molina, A. Ramakrishnan, Li Shen, 2023, bioRxiv.

Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity

H. Molina, Li Shen, I. Maze, 2023, bioRxiv.

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.

I. Abe, Wen Liu, T. Awakawa, 2013, Angewandte Chemie.