R. Then

M. Arisawa, M. Glauser, R. Then, 1983, Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious....

Lipopolysaccharide alterations responsible for combined quinolone and beta-lactam resistance in Pseudomonas aeruginosa.

R. Then, H. Leying, K. Büscher, 1992, Chemotherapy.

The biochemical basis of the antimicrobial action of sulfonamides and trimethoprim in vivo-II. Experiments on the limited thymine and thymidine availability in blood and urine.

R. Then, P. Angehrn, 1975, Biochemical pharmacology.

DNA and RNA Synthesis: Antifolates

R. Then, I. Kompiš, K. Islam, 2005 .

[Effects of trimethoprim and its antagonists on RNA synthesis in Escherichia coli].

R. Then, P. Angehrn, 1972, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Resistance to Sulfonamides

R. Then, 1989 .

Identical genes for trimethoprim‐resistant dihydrofolate reductase from Staphylococcus aureus in Australia and Central Europe

W. Bannwarth, R. Then, A. Burdeska, 1990, FEBS letters.

In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil

R. Then, P. Angehrn, P. Hohl, 1989, European Journal of Clinical Microbiology and Infectious Diseases.

The targets of currently used antibacterial agents: lessons for drug discovery.

R. Lange, H. Locher, R. Then, 2007, Current pharmaceutical design.

Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii

H. R. Chang, D. Arsenijevic, R. Then, 1994, Antimicrobial Agents and Chemotherapy.

Bacterial Dihydrofolate Reductase

R. Then, 2007 .

Characterization of the gene for chromosomal trimethoprim-sensitive dihydrofolate reductase of Staphylococcus aureus ATCC 25923

G. Dale, D. Stüber, R. Then, 1993, Antimicrobial Agents and Chemotherapy.

Dihydrofolate Reductases in Some Folate-Requiring Bacteria with Low Trimethoprim Susceptibility

H. Riggenbach, R. Then, 1978, Antimicrobial Agents and Chemotherapy.

Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313

M. Page, G. Dale, H. Langen, 1995, Antimicrobial agents and chemotherapy.

haemolyticus MUR 313 . dihydrofolate reductase from Staphylococcus plasmid-encoded trimethoprim-resistant Cloning and characterization of a novel

M. Page, G. Dale, H. Langen, 1995 .

Low Trimethoprim Susceptibility of Anaerobic Bacteria Due to Insensitive Dihydrofolate Reductases

R. Then, P. Angehrn, Peter Angehrn, 1979, Antimicrobial Agents and Chemotherapy.

N‐terminal amino acid sequence of the chromosomal dihydrofolate reductase purified from trimethoprim‐resistant Staphylococcus aureus

P. Hartman, H. Kocher, R. Then, 1988, FEBS letters.

Antibacterial properties of Ro 40-6890, a broad-spectrum cephalosporin, and its novel orally absorbable ester, Ro 41-3399

M. Page, C. Hubschwerlen, R. Then, 1992, Antimicrobial Agents and Chemotherapy.

Antibacterial Properties ofRo40-6890, aBroad-Spectrum Cephalosporin, andItsNovelOrally Absorbable Ester, Ro41-3399 PETERANGEHRN,*PETERHOHL,CHRISTIANHUBSCHWERLEN,

M. Page, R. Then, 1992 .

[Potentiation by EDTA and levallorphan of the effect of sulfamethoxazole-trimethoprim on Escherichia coli].

R. Then, 1972, Experientia.

6-(E)-acetylmethylenepenicillanic acid, a potent beta-lactamase inhibitor.

R. Then, P. Angehrn, S. Adam, 1987, The Journal of antibiotics.

Multiply resistant mutants of Enterobacter cloacae selected by beta-lactam antibiotics

R. Then, P. Angehrn, 1986, Antimicrobial Agents and Chemotherapy.

Ability of newer beta-lactam antibiotics to induce beta-lactamase production inEnterobacter cloacae

R. Then, 1987, European Journal of Clinical Microbiology.

Interaction of Ro 17–2301 (AMA-1080) with β-Lactamases

R. Then, 1984 .

Affinity of carumonam for penicillin-binding proteins.

I. Kohl, R. Then, 1985, Chemotherapy.

Properties of brodimoprim as an inhibitor of dihydrofolate reductases.

R L Then, F Hermann, R. Then, 1984, Chemotherapy.

In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity

M. Arisawa, R. Then, S. Shimizu, 1991, Antimicrobial Agents and Chemotherapy.

InVitro andInVivoEvaluation ofRo09-1428, aNew Parenteral Cephalosporin withHighAntipseudomonal Activity

M. Arisawa, R. Then, S. Shimizu, 1991 .

Properties of Ro 13-99041 as a substrate and inhibitor of beta-lactamases.

R. Then, 1981, Chemotherapy.

Cefetamet: Its In Vitro Activity and Interaction with β-Lactamases and Penicillin-Binding Proteins

R. Then, Wolfgang Cullmann, 1991 .

Mechanism of inhibition of chromosomal beta-lactamases by third-generation cephalosporins.

R. Charnas, R. Then, 1988, Reviews of infectious diseases.

Investigations on the mode of action of the combination sulfamethoxazole-trimethoprim.

R. Then, P. Angehrn, 1973, Chemotherapy.

Parasitic Dihydrofolate Reductase

R. Then, 2008 .

Purification of guanosine triphosphate cyclohydrolase I and dihydrofolate reductase on a dihydrofolate-Sepharose affinity column.

R. Then, 1979, Analytical biochemistry.

Mode of Action of Sulfanilyl Fluoroquinolones

R. Manzo, F. Alovero, Marcelo J. Nieto, 1998, Antimicrobial Agents and Chemotherapy.

Neisseriaceae, a group of bacteria with dihydrofolate reductases, moderately susceptible to trimethoprim.

R. Then, 1979, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie.

Rationally designed brodimoprim analogues: synthesis and biological activities

R. Then, I. Kompiš, 1985 .

Anti-infective strategies of the future: is there room for species-specific antibacterial agents?

H. Sahl, R. Then, 2010, Current pharmaceutical design.

Penicillin-Sensitive Transpeptidase

R. Then, 2008 .