T. Sumiyoshi

发表

Molecular assembly and gelating behavior of didodecanoylamides of alpha,omega-alkylidenediamines.

K. Tomioka, Y. Miwa, M. Nakano, 2001, Journal of the American Chemical Society.

Molecular Assembly of C2-Symmetric Bis-(2S)-2-methyldodecanoylamides of α,ω-Alkylidenediamines into Coiled Coil and Twisted Ribbon Aggregates

K. Tomioka, K. Nishimura, Y. Miwa, 2003 .

Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists.

T. Enomoto, K. Takai, A. Kiyoshi, 2014, Bioorganic & medicinal chemistry letters.

Discovery of N-sulfonyl-7-azaindoline derivatives as potent, orally available and selective M(4) muscarinic acetylcholine receptor agonists.

T. Enomoto, K. Takai, A. Kiyoshi, 2014, Bioorganic & medicinal chemistry letters.

Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M(1) and M(4) muscarinic acetylcholine receptors agonists.

T. Enomoto, K. Takai, A. Kiyoshi, 2013, Bioorganic & medicinal chemistry letters.

Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.

T. Enomoto, K. Takai, A. Kiyoshi, 2013, ACS medicinal chemistry letters.

Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors.

K. Nunomura, Minoru Yoshida, A. Ito, 2022, ACS Medicinal Chemistry Letters.

Process Development for the Synthesis of a Selective M1 and M4 Muscarinic Acetylcholine Receptors Agonist

Kazuki Hashimoto, T. Sumiyoshi, Y. Hiyama, 2017 .

Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M(1) and M(4) muscarinic acetylcholine receptors agonists.

T. Enomoto, K. Takai, T. Nakako, 2015, Bioorganic & medicinal chemistry letters.

Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood–Brain Barrier

T. Terasaki, Y. Kubo, Yasuo Uchida, 2022, Pharmaceutics.

Asymmetric synthesis of the 6-cyanoindole derivatives as non-steroidal glucocorticoid receptor modulators using (+)- and (−)-tert-butyl 6-cyano-3-[3-ethoxy-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl]-1H-indole-1-carboxylate

D. Urabe, K. Tojo, M. Tobe, 2011 .

Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors.

H. Toda, N. Nomura, T. Sumiyoshi, 2014, Bioorganic & medicinal chemistry letters.

Syntheses of [14C]-labeled 2-(3-chlorophenyloxy)-3-[3-(3-hydroxy) pyridin-4-yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites.

Yusuke Sawayama, T. Sumiyoshi, M. Kawasaki, 2014, Journal of labelled compounds & radiopharmaceuticals.

Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors.

T. Sumiyoshi, Y. Teranishi, Akira Fusano, 2013, Bioorganic & medicinal chemistry.

Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Minoru Yoshida, A. Ito, Y. Nagaoka, 2018, ACS medicinal chemistry letters.

GPR91 antagonist and TGF-β inhibitor suppressed collagen production of high glucose and succinate induced HSC activation.

K. Urayama, T. Sumiyoshi, Mutsuko Sakai, 2020, Biochemical and biophysical research communications.

A short synthesis of (+)-β-lycorane by asymmetric conjugate addition cascade

K. Tomioka, K. Nishimura, M. Yamashita, 2015 .

Total synthesis of (-)-lycorine and (-)-2-epi-lycorine by asymmetric conjugate addition cascade.

K. Tomioka, K. Nishimura, M. Yamashita, 2009, Organic letters.

Cyclic Model for the Asymmetric Conjugate Addition of Organolithiums with Enoates

K. Tomioka, K. Nishimura, M. Yamashita, 2015 .

Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities.

Yoshiyuki Hirata, Tsutomu Sasaki, S. Uesato, 2016, Bioorganic & medicinal chemistry.

MDMX elevation by a novel Mdmx–p53 interaction inhibitor mitigates neuronal damage after ischemic stroke

Tsutomu Sasaki, Minoru Yoshida, S. Matsumura, 2022, Scientific Reports.

Muscarinic Acetylcholine Receptor Activators

T. Enomoto, T. Sumiyoshi, 2014 .

A novel piperidine degradation mechanism in a newly isolated piperidine degrader Pseudomonas sp. strain KU43P.

H. Iwaki, Y. Hasegawa, T. Sumiyoshi, 2020, The Journal of general and applied microbiology.

Asymmetric Synthesis of the Carbon-14-Labeled Selective Glucocorticoid Receptor Modulator using Cinchona Alkaloid Catalyzed Addition of 6-Bromoindole to Ethyl Trifluoropyruvate

D. Urabe, M. Sakamoto, K. Tojo, 2012, Molecules.

Nano-Honeycomb Electrode-Based QCM Sensor and Its Application for PPI Detection

T. Shimizu, S. Shingubara, Y. Nagaoka, 2019, IEEE Sensors Journal.

Experimental and computational study of intermolecular migration of N,N-dimethylcarbamoyl group from N(7) to N(1) on a 7-azaindoline derivative

N. Fujiwara, K. Takai, Kazuki Hashimoto, 2013 .

Design, synthesis and evaluations of spiro‐fused benzoxaborin derivatives as novel boron‐containing compounds

Y. Nagaoka, T. Sumiyoshi, Itaru Natsutani, 2019, Chemical biology & drug design.