Guojun Hou

发表

SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

M. Weirauch, B. Namjou, J. Harley, 2021, Nature communications.

SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

M. Weirauch, B. Namjou, J. Harley, 2020, bioRxiv.

Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease.

N. Shen, Guojun Hou, Zhaorui Cheng, 2022, Journal of autoimmunity.

Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

M. Weirauch, B. Namjou, J. Harley, 2022, Nature Communications.

The transcription factor Zeb2 drives differentiation of age-associated B cells

C. Vinuesa, N. Shen, Haibo Zhou, 2021, bioRxiv.

The MicroRNA miR-22 Represses Th17 Cell Pathogenicity by Targeting PTEN-Regulated Pathways

Yuanjia Tang, N. Shen, Wenfei Jin, 2020, ImmunoHorizons.

Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR-21–Peli1–c-Rel Pathway Prevents Autoimmunity

N. Shen, Wenfei Jin, Zhijun Han, 2020, The Journal of Immunology.

Targeting PTEN-Regulated Pathways Represses Th17 Cell Pathogenicity by miR-22 The MicroRNA

Yuanjia Tang, N. Shen, Zhijun Han, 2020 .

TGF-β1 signaling remodels TH17 cell chromatin architecture for metabolic reprogramming

Yuanjia Tang, N. Shen, J. Qian, 2018 .

MiR-21 Regulates Metabolic Adaptation of TH17 Cells during Autoimmunity and Host Defence

Yuanjia Tang, N. Shen, J. Qian, 2018 .

MicroRNA-21 Regulates Metabolic Adaptation of Pathogenic TH17 cells and Controls Autoimmune Inflammation

Yuanjia Tang, N. Shen, J. Qian, 2017, bioRxiv.

T-bet+ CD11c+ B cells are critical for anti-chromatin IgG production in the development of lupus

Lingling Wu, J. Harley, Yuanjia Tang, 2017, bioRxiv.

CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery

M. Weirauch, B. Namjou, J. Harley, 2021, bioRxiv.

Identification of Renal Long Non-coding RNA RP11-2B6.2 as a Positive Regulator of Type I Interferon Signaling Pathway in Lupus Nephritis

Lingling Wu, N. Shen, Jianyang Ma, 2019, Front. Immunol..

Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus

Yongfei Wang, Yuanjia Tang, N. Shen, 2022, Arthritis & rheumatology.

Association of Abnormal Elevations in IFIT3 With Overactive Cyclic GMP‐AMP Synthase/Stimulator of Interferon Genes Signaling in Human Systemic Lupus Erythematosus Monocytes

Lingling Wu, N. Shen, J. Qian, 2018, Arthritis & Rheumatology.

The transcription factor Zeb2 drives formation of age-associated B cells

C. Vinuesa, N. Shen, Haibo Zhou, 2021, bioRxiv.

Identification of Two Subsets of Subcompartment A1 Associated with High Transcriptional Activity and Frequent Loop Extrusion

S. Q. Xie, Ya Guo, Yufan Xie, 2023, Biology.

Involvement of Transcriptional Factor Pbx1 in Peripheral B Cell Homeostasis to Constrain Lupus Autoimmunity

Haibo Zhou, J. Qian, Z. Yin, 2023, Arthritis & rheumatology.

Association of Abnormal Elevations in IFIT3 With Overactive Cyclic GMP‐AMP Synthase/Stimulator of Interferon Genes Signaling in Human Systemic Lupus Erythematosus Monocytes

Lingling Wu, N. Shen, J. Qian, 2018, Arthritis & rheumatology.

The transcription factor ZEB2 drives formation of age-associated B cells

M. Weirauch, Jianyang Ma, L. Kottyan, 2021, bioRxiv.

Non-coding DNA variants for risk in lupus.

Guojun Hou, Yutong Zhang, Nan Shen, 2024, Best practice & research. Clinical rheumatology.

SPATS2L is a positive feedback regulator of the type I interferon signaling pathway and plays a vital role in lupus.

Guojun Hou, Yue Yang, Wanling Yang, 2024, Acta biochimica et biophysica Sinica.

704 Global identification of lupus genetic risk variants modulating the type I interferon pathway through CRISPR-based genomic screening

Guojun Hou, Xinyi Zhu, Zhaorui Cheng, 2024, Epidemiology & Outcomes.

Three‐Dimensional Chromosomal Landscape Revealing miR‐146a Dysfunctional Enhancer in Lupus and Establishing a CRISPR‐Mediated Approach to Inhibit the Interferon Pathway

Yuanjia Tang, Jianyang Ma, Z. Yin, 2023, Arthritis & rheumatology.