M. Ferrandi

发表

Istaroxime Metabolite PST3093 Selectively Stimulates SERCA2a and Reverses Disease-Induced Changes in Cardiac Function

F. Peri, G. Bianchi, M. Rocchetti, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Adducin polymorphisms and the treatment of hypertension.

L. Citterio, P. Manunta, C. Lanzani, 2007, Pharmacogenomics.

Ouabain Contributes to Kidney Damage in a Rat Model of Renal Ischemia-Reperfusion Injury

F. Montorsi, A. Salonia, M. Rastaldi, 2016, International journal of molecular sciences.

Endogenous ouabain and hemodynamic and left ventricular geometric patterns in essential hypertension.

P. Manunta, F. Cuccurullo, S. Pierdomenico, 1998, American journal of hypertension.

alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy.

F. Macciardi, M. Rastaldi, D. Cusi, 2010 .

PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.

G. Bianchi, P. Ferrari, L. Torielli, 1999, The Journal of pharmacology and experimental therapeutics.

Renal Na,K-ATPase in genetic hypertension.

G. Bianchi, P. Parenti, A. Shainskaya, 1996, Hypertension.

Red blood cell abnormalities and spontaneous hypertension in the rat. A genetically determined link.

G. Bianchi, P. Ferrari, E. Polli, 1985, Hypertension.

Cation Transport Abnormalities in Human and Rat Essential Hypertension

D. Cusi, C. Barlassina, G. Bianchi, 1984 .

Erythrocyte membrane transport systems as possible markers for essential hypertension

G. Bianchi, M. Ferrandi, D. C. C. Barlassina, 1982 .

Familial aggregation of cation transport abnormalities and essential hypertension.

D. Cusi, C. Barlassina, G. Bianchi, 1981, Clinical and experimental hypertension.

Relationship between altered Na+--K+ cotransport and Na+--Li+ countertransport in the erythrocytes of 'essential' hypertensive patients.

D. Cusi, C. Barlassina, G. Bianchi, 1981, Clinical science.

Lack of Salt-Inducible Kinase 2 (SIK2) Prevents the Development of Cardiac Hypertrophy in Response to Chronic High-Salt Intake

A. Hamsten, Sergej Popov, A. Franco‐Cereceda, 2014, PloS one.

Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

G. Vassalli, G. Milano, M. Rocchetti, 2021, Frontiers in Physiology.

Na+/K+/Cl(-)-cotransporter mediated Rb+ fluxes in membrane vesicles from kidneys of normotensive and hypertensive rats.

P. Parenti, P. Ferrari, S. Karlish, 1990, Biochimica et biophysica acta.

Na+,2Cl-,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives.

B. Masereel, B. Pirotte, P. Parenti, 1992, European journal of pharmacology.

Endogenous ouabain in cardiovascular function and disease

P. Manunta, G. Bianchi, J. Hamlyn, 2009, Journal of hypertension.

Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.

G. Bianchi, P. Ferrari, M. Ferrandi, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Ouabain-like factor quantification in mammalian tissues and plasma: comparison of two independent assays.

P. Manunta, J. Hamlyn, P. Ferrari, 1997, Hypertension.

adducin-dependent hypertension - ATPase alterations in ouabain and + -K + and vascular Na Rostafuroxin: an ouabain antagonist that corrects renal

G. Bianchi, P. Ferrari, M. Ferrandi, 2016 .

Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.

P. Manunta, G. Bianchi, P. Ferrari, 2007, Medical hypotheses.

Genetic mechanisms underlying the regulation of urinary sodium excretion and arterial blood pressure: the role of adducin.

G. Bianchi, M. Ferrandi, 2000, Acta physiologica Scandinavica.

Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone

A. Heagerty, A. Greenstein, S. Withers, 2011, Journal of hypertension.

Glomerular barrier dysfunction in glomerulosclerosis‐ resistant Milan rats with experimental diabetes: the role of renal haemodynamics

S. Menini, M. Rastaldi, G. Pugliese, 2007, The Journal of pathology.

Late sodium current (INaL) in pancreatic β-cells

F. Bertuzzi, M. Rocchetti, A. Zaza, 2014, Pflügers Archiv - European Journal of Physiology.

Ouabain-like factor: is this the natriuretic hormone?

P. Manunta, M. Ferrandi, 2000, Current opinion in nephrology and hypertension.

SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy

C. Bussadori, G. Bianchi, M. Rocchetti, 2021, Cardiovascular research.

Rostafuroxin Protects from Podocyte Injury and Proteinuria Induced by Adducin Genetic Variants and Ouabain

M. Rastaldi, P. Manunta, G. Bianchi, 2014, The Journal of Pharmacology and Experimental Therapeutics.

cGMP-Dependent Protein Kinase 1 Polymorphisms Underlie Renal Sodium Handling Impairment

J. Staessen, T. Kuznetsova, L. Citterio, 2013, Hypertension.

PST2238: a new antihypertensive compound that antagonizes the long-term pressor effect of ouabain.

L. Vesci, F. Conti, P. Ferrari, 1998, The Journal of pharmacology and experimental therapeutics.

Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan

J. Staessen, R. Bigazzi, C. Chiang, 2021, The pharmacogenomics journal.

PST 2238: A New Antihypertensive Compound that Modulates Na+,K+‐ATPase and Antagonizes the Pressor Effect of OLF

G. Bianchi, P. Ferrari, L. Torielli, 2006 .

The endogenous ouabain: molecular basis of its role in hypertension and cardiovascular complications.

P. Manunta, G. Bianchi, P. Ferrari, 2005, Frontiers in bioscience : a journal and virtual library.

Antihypertensive Compounds That Modulate the Na‐K Pump

G. Bianchi, P. Ferrari, L. Torielli, 2003, Annals of the New York Academy of Sciences.

PST 2238: A New Antihypertensive Compound That Modulates Renal Na-K Pump Function Without Diuretic Activity in Milan Hypertensive Rats

G. Bianchi, P. Ferrari, M. Ferrandi, 2002, Journal of cardiovascular pharmacology.

PST 2238: a new antihypertensive compound that modulates the Na-K pump 'in vivo' and 'in vitro'.

P. Ferrari, L. Torielli, M. Ferrandi, 2000, Hypertension research : official journal of the Japanese Society of Hypertension.

Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension.

P. Manunta, G. Bianchi, P. Ferrari, 1999, The American journal of physiology.

Role of the ouabain-like factor and Na-K pump in rat and human genetic hypertension.

P. Manunta, G. Bianchi, P. Ferrari, 1998, Clinical and experimental hypertension.

Increased Na pump activity in the kidney cortex of the Milan hypertensive rat strain

P. Parenti, P. Ferrari, M. Villa, 1991, FEBS letters.

Erythrocyte adducin differential properties in the normotensive and hypertensive rats of the Milan strain. Characterization of spleen adducin m-RNA.

G. Borsani, F. Baralle, A. Sidoli, 1989, American journal of hypertension.

Relationship between erythrocyte volume and sodium transport in the Milan hypertensive rat and age-dependent changes.

M. Canessa, P. Ferrari, L. Torielli, 1987, Journal of hypertension.

Volumes and Na Transports in Intact Red Blood Cells, Resealed Ghosts, and Inside‐Out Vesicles of Milan Hypertensive Rats

G. Bianchi, P. Ferrari, L. Torielli, 1986 .

Plasma Ouabain-Like Factor During Acute and Chronic Changes in Sodium Balance in Essential Hypertension

D. Cusi, P. Manunta, C. Lanzani, 2001, Hypertension.

Cardiac glycosides and cardiomyopathy.

P. Manunta, M. Ferrandi, 2006, Hypertension.

Effect of canrenone and hydrochlorothiazide on the development of hypertension in rat models of genetic hypertension

G. Bianchi, P. Ferrari, M. Ferrandi, 1993, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.

M. Gheorghiade, A. Ambrosy, P. Ferrari, 2011, Discovery medicine.

Ouabainlike factor in Milan hypertensive rats.

P. Ferrari, S. Salardi, M. Ferrandi, 1992, The American journal of physiology.

Investigating Genetic Variability between the MHS Hypertensive Strain of Rats and its Normotensive Control, MNS

P. Parenti, P. Ferrari, L. Torielli, 1988 .

Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension.

D. Cusi, P. Manunta, D. Ciurlino, 1999, Hypertension.

NKCC2 is activated in Milan hypertensive rats contributing to the maintenance of salt-sensitive hypertension

G. Valenti, M. Svelto, G. Bianchi, 2011, Pflügers Archiv - European Journal of Physiology.

Characteristics of a ouabain-like factor from Milan hypertensive rats.

P. Ferrari, S. Salardi, M. Ferrandi, 1993, Journal of cardiovascular pharmacology.

Preoperative Endogenous Ouabain Predicts Acute Kidney Injury in Cardiac Surgery Patients*

O. Alfieri, S. Gottlieb, A. Zangrillo, 2013, Critical care medicine.

Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies

Erika Salvi, Fabio Macciardi, Jan A Staessen, 2010, Science Translational Medicine.

Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats.

H. Zimdahl, N. Hubner, G. Bianchi, 2004, Biochemical and biophysical research communications.

Two point mutations within the adducin genes are involved in blood pressure variation.

D. Cusi, G. Casari, G. Bianchi, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin.

P. Manunta, P. Ferrari, M. Ferrandi, 2006, Cardiovascular & hematological agents in medicinal chemistry.

Abstract P118: Antihypertensive Treatment Guided By Genetics: Pearl-ht, The Randomized Proof-of-concept Trial Comparing Rostafuroxin With Losartan

J. Staessen, C. Chiang, L. Citterio, 2020, Hypertension.

Personalized Therapy of Hypertension: the Past and the Future

J. Staessen, D. Cusi, P. Manunta, 2016, Current Hypertension Reports.

Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 1: Experimental Studies

M. Rastaldi, G. Bianchi, P. Ferrari, 2010, Science Translational Medicine.

Organ Hypertrophic Signaling within Caveolae Membrane Subdomains Triggered by Ouabain and Antagonized by PST 2238*

G. Bianchi, P. Ferrari, M. Ferrandi, 2004, Journal of Biological Chemistry.

α- and β-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy

F. Macciardi, M. Rastaldi, D. Cusi, 2009, Journal of Molecular Medicine.

Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

G. Bianchi, P. Ferrari, F. Tadini-Buoninsegni, 2013, British journal of pharmacology.

Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.

O. Parodi, G. Bianchi, P. Ferrari, 2007, The American journal of cardiology.

Involvement of the Na+,K+-ATPase and its inhibitors in cardiovascular diseases

L. Quadri, M. Ferrandi, 1998 .

Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension.

G. Bianchi, P. Ferrari, M. Ferrandi, 2006, Cellular and molecular biology.

Different effects of marinobufagenin and endogenous ouabain.

P. Manunta, M. Ferrandi, 2004, Journal of hypertension.

Evidence for an interaction between adducin and Na+-K+-ATPase: relation to genetic hypertension.

P. Manunta, G. Bianchi, P. Ferrari, 1999, American journal of physiology. Heart and circulatory physiology.

Effect of amiloride analogues on sodium transport in renal brush border membrane vesicles from Milan hypertensive rats.

P. Parenti, P. Ferrari, G. Hanozet, 1992, Biochemical and biophysical research communications.

Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension

G. Capasso, F. Trepiccione, L. Zagato, 2014, BBA clinical.

Circulating Natriuretic Factor in the Pathogenesis of Genetic Hypertension of Renal Origin

G. Bianchi, P. Ferrari, L. Torielli, 1987 .

Why is [Ca2+]i increased in blood cells in primary hypertension?

G. Orlandini, G. Bianchi, A. Cavatorta, 1985, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

The Milan hypertensive rat as a model for studying cation transport abnormality in genetic hypertension.

G. Bianchi, P. Ferrari, L. Torielli, 1987, Hypertension.

Early consequences of the phospholamban mutation PLN-R14del+/- in a transgenic mouse model

R. D. de Boer, E. Sacco, F. Lodola, 2023, bioRxiv.

Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure

F. Peri, G. Bianchi, M. Rocchetti, 2022, Journal of medicinal chemistry.

PST 2238 a new antihypertensive compound that modulates renal Na-KATPase in genetic hypertension.

G. Bianchi, P. Ferrari, L. Torielli, 1999 .

Characterization of erythrocyte adducin from the Milan hypertensive strain of rats

G. Bianchi, P. Ferrari, L. Torielli, 1988, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Selective SERCA2a activator as a candidate for chronic heart failure therapy

M. Rocchetti, Carlotta Ronchi, M. Arici, 2024, Journal of Translational Medicine.

Istaroxime stimulates SERCA 2 a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition 1 Running title : Istaroxime stimulation of SERCA 2 a in heart failure

G. Bianchi, P. Ferrari, F. Tadini-Buoninsegni, 2013 .

Renal Abnormalities at the Prehypertensive Stage of Essential Hypertension

D. Cusi, C. Barlassina, R. Colombo, 1988, Journal of cardiovascular pharmacology.

Rostafuroxin Protects from Podocyte Injury and Proteinuria Induced by Adducin Genetic Variants and Ouabain

M. Rastaldi, P. Manunta, G. Bianchi, 2014, The Journal of Pharmacology and Experimental Therapeutics.

SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury.

M. Rastaldi, P. Manunta, V. Matafora, 2014, Human molecular genetics.

SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury.

M. Rastaldi, P. Manunta, V. Matafora, 2017, Human molecular genetics.