J. Gougoutas

发表

Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.

David S. Nirschl, David S Nirschl, A. Doweyko, 2013, Bioorganic & medicinal chemistry letters.

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

S. Spergel, G. Trainor, L. Schweizer, 2015, ACS medicinal chemistry letters.

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.

Michael A. Galella, A. Fura, S. Krystek, 2008, Bioorganic & medicinal chemistry letters.

Structures of rubratoxins A and B.

G. Büchi, K. Snader, J. D. White, 1970, Journal of the American Chemical Society.

A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor

S. Leung, R. Randazzo, K. Volk, 2012 .

Synthesis, Stability, and Crystal Structure Studies of Some Ca2+, Cu2+, and Zn2+ Complexes of Macrocyclic Polyamino Carboxylates

M. Tweedle, Krishan Kumar, M. Malley, 1995 .

Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC.

A. Nunn, W. Eckelman, K. Linder, 1991, Bioconjugate chemistry.

Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.

J. Barrish, P. Carter, T. G. Dhar, 2009, Bioorganic & medicinal chemistry letters.

Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism.

Y. Shu, Xiaolin Cao, L. Nafie, 2006, Chirality.

SAR and pH stability of cyano-substituted epothilones.

Soong-Hoon Kim, Kenneth J. Leavitt, C. Fairchild, 2002, Organic letters.

Synthesis, structure proof, and biological activity of epothilone cyclopropanes.

J. Tokarski, C. Fairchild, F. Lee, 2000, Organic letters.

Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.

Rongan Zhang, S. Moreland, S. D. Kimball, 1995, Journal of medicinal chemistry.

Benzazepinone calcium channel blockers. 3. Synthesis and structure-activity studies of 3-alkylbenzazepinones.

J. Das, R. Moquin, D. Floyd, 1992, Journal of medicinal chemistry.

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

K. J. Yost, M. Kirby, N. Grazier, 2001, Journal of medicinal chemistry.

N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.

K. Kish, L. Hamann, A. Fura, 2009, Journal of medicinal chemistry.

The crystal structure of 21-bromo-9α-fluoro-11β-hydroxy-16α, 17α-(β-methyl-α-phenylmethylenedioxy)-4-pregnene-3.20, dione

J. Gougoutas, G. Krakower, B. T. Keeler, 1971 .

Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.

J. Barrish, Hai-yun Xiao, S. Nadler, 2010, Journal of medicinal chemistry.

Structure of Obafluorin (I): An Antibacterial β-Lactone from Pseudomonas fluorescens.

A. Tymiak, M. Malley, J. Gougoutas, 1986 .

Structure of obafluorin: an antibacterial .beta.-lactone from Pseudomonas fluorescens

A. Tymiak, M. Malley, J. Gougoutas, 1985 .

One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.

Michael A. Galella, P. Stein, N. Grazier, 2004, The Journal of organic chemistry.

Efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921.

Chien-Kuang Chen, Bo Zhang, E. Vawter, 2003, Organic letters.

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

S. Moreland, S. D. Kimball, M. Malley, 1992, Journal of medicinal chemistry.

Synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid esters

M. Malley, J. Gougoutas, K. Atwal, 1987 .

Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.

N. Meanwell, J. Buchanan, J. Romine, 1993, Journal of medicinal chemistry.

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

S. Moreland, D. Floyd, S. D. Kimball, 1990, Journal of medicinal chemistry.

Synthesis, characterization, and crystal structures of M(DO3A) (M = Fe, Gd) and Na[M(DOTA)] (M = Fe, Y, Gd)

M. Tweedle, Krishan Kumar, L. Wilson, 1993 .

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

S. Moreland, D. Floyd, M. Malley, 1990, Journal of medicinal chemistry.

Synthesis of 4-methyl-2-benzazepin-3-one analogs of diltiazem

J. Hunt, M. Malley, J. Gougoutas, 1990 .

Structure of a 3:2 adduct from the reaction of dimethyl acetylenedicarboxylate and cyclohexyl isocyanide

W. Saenger, J. Gougoutas, 1971 .

Synthesis of Substituted 1,2,3,4-Tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic Acid Esters.

M. Malley, J. Gougoutas, K. Atwal, 1987 .

Dihydropyrimidine Calcium Channel Blockers. Part 2. 3-Substituted 4- Aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic Acid Esters as Potent Mimics of Dihydropyridines.

S. Moreland, D. Floyd, S. D. Kimball, 1991 .

Regioselective Coupling of Tetraalkylammonium Salts of 6-Iodo-2-aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS-180,194, a Potent Antiviral Carbocyclic Nucleoside

T. Mitt, G. Bisacchi, R. Zahler, 1995 .

Chlorination of the cephem dihydrothiazine ring. Factors influencing C-2 substitution vs. degradation to isothiazoles1

J. E. Dolfini, W. Koster, J. Gougoutas, 1978 .

6-methyl penicillins and 7-methyl cephalosporins.

J. E. Dolfini, H. Applegate, J. Gougoutas, 1971, Journal of the American Chemical Society.

Studies on the symmetric synthesis of alpha-amino acids. II. New systems for highly specific asymmetric synthesis with conservation of the Chiral reagent.

E. Corey, W. Saenger, J. Gougoutas, 1970, Journal of the American Chemical Society.

Practical synthesis of an enantiomerically pure synthon for the preparation of mevinic acid analogs

D. Karanewsky, M. Malley, J. Gougoutas, 1991 .

Synthesis of 7.alpha.-methoxycephalosporins

J. E. Dolfini, H. Applegate, M. Puar, 1974 .

Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase

R. Lawrence, T. Harrity, S. Lan, 1996 .

Sulfenyl transfer rearrangement of sulfenimines (thiooximes). A novel synthesis of 7.alpha.-methoxycephalosporins and 6.alpha.-methoxypenicillins

E. Gordon, H. W. Chang, C. Cimarusti, 1980 .

A Novel Application of a Pd(0)-Catalyzed Nucleophilic Substitution Reaction to the Regio- and Stereoselective Synthesis of Lactam Analogues of the Epothilone Natural Products

Soong-Hoon Kim, C. Fairchild, R. Borzilleri, 2000 .

X-ray studies of reactions in organic solids

J. Gougoutas, 1971 .

A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes.

P. Stein, C. S. Madsen, H. Monshizadegan, 2005, Bioorganic & medicinal chemistry letters.

Studies towards understanding the mechanism of the unusual rearrangement of certain 5-propargyloxyindoles

J. Macor, M. Malley, J. Gougoutas, 2000 .

Conformational Switching and the Synthesis of Spiro[2H-indol]-3(1H)-ones by Radical Cyclization.

S. Biller, R. Sulsky, J. Gougoutas, 1999, The Journal of organic chemistry.

Aerocavin, a new antibiotic produced by Chromobacterium violaceum.

J. S. Wells, R. Sykes, W. Trejo, 1988, The Journal of antibiotics.

Confirmation of the structure of tetra-O-(tert-butyldimethylsilyl)-D-glucono-1,4-lactone formed by silylation of D-glucono-1,5-lactone.

J. Gougoutas, Janak Singh, T. P. Kissick, 2002, Carbohydrate research.

Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions

W. Parker, J. Gougoutas, A. Cohen, 1979 .

A meso specific reaction

J. Thottathil, C. Przybyla, M. Malley, 1986 .

Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers.

S. Moreland, S. D. Kimball, M. Porubcan, 1988, Journal of medicinal chemistry.

The Enantioselective Synthesis of anti-β-Hydroxy-α-Amino Acids via the Reaction of Lithium Enolates of Glycine Bearing an Oxazolidine Chiral Auxiliary with Aldehydes

Henry H. Gu, E. Iwanowicz, P. Cheng, 1998 .

Sulfonation with Inversion by Mitsunobu Reaction: An Improvement on the Original Conditions.

K. A. Colapret, N. Anderson, J. Simpson, 1996, The Journal of organic chemistry.

Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole Dihydrochloride

Andrew Nguyen, Chien-Kuang Chen, N. Anderson, 1997 .

Chemistry of Tc(oxime)3 (μ -OH)SnCl3 and TcCl(oxime)3: Neutral intermediates in the synthesis of boron-caped 99-TcOXIME complexes

A. Nunn, K. Linder, S. Unger, 1989 .

A re‐assessment of the oxidation state of Tc(DMG)3(μ‐OH)SnCl3: Evidence for Tc(III)

A. Nunn, K. Linder, S. Unger, 1989 .

Synthesis, stability, and structure of gadolinium(III) and yttrium(III) macrocyclic poly(amino carboxylates)

Michael F. Tweedle, Mary F. Malley, Jack Z. Gougoutas, 1994 .

Synthesis, characterization, and crystal structure of the gadolinium(III) chelate of (1R,4R,7R)-.alpha.,.alpha.',.alpha.''-trimethyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3MA)

Michael F. Tweedle, Mary F. Malley, Jack Z. Gougoutas, 1993 .

Solid-state chemistry of organic polyvalent iodine compounds. VI. The crystal structure and topotactic hydrolysis of 3-oxo-3H-2,1-benzoxiodol-1-yl o-fluorobenzoate

M. C. Etter, J. Gougoutas, Kuo-Hui Chang, 1976 .

An unexpected by-product obtained during the preparation of technetium(III) boronic acid adducts of dioximes. The single crystal structure of TcCl(DMG)2(BDI)BEt (DMG=dimethylglyoxime, BDI=butane-2, 3-dione imine-oxime)

A. Nunn, D. Nowotnik, M. Malley, 1991 .

The identification of prostaglandins E2, F2α and A2 from rabbit kidney medulla

J. Gougoutas, B. Takman, K. Crowshaw, 1967 .

Solid-state coordination bonding to polyvalent iodine—The structure of 1-acetoxy-1,2-benziodoxolin-3-one

J. Clardy, J. Gougoutas, 1972 .

Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2.

P. Sprague, D. Harris, M. Malley, 1985, Journal of medicinal chemistry.

Novel 1,4-Homofragmentation via an α-Lactone

F. Buono, M. Malley, J. Gougoutas, 2006 .

Regioselective Coupling of Tetraalkylammonium Salts of 6‐Iodo‐2‐ aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS‐180,194, a Potent Antiviral Carbocyclic Nucleoside.

T. Mitt, G. Bisacchi, R. Zahler, 1995 .

A New Reaction of Thionyl Chloride with a Carboxylic Acid in the Presence of a Tertiary Amine. An X-Ray Crystallographic Proof of Structure of α-Chloro-α-chlorosulfenyl-4-nitro-2,5-dimethoxyphenylacetyl Chloride

W. Saenger, J. Gougoutas, J. B. Rogers, 1967 .

Crystal structure and solid-state behavior of a diazonium iodide: 3-carboxy-2-naphthalenediazonium iodide hydrate

J. Gougoutas, 1979 .

Solid-state chemistry of organic polyvalent iodine compounds. 10. Sequential, competitive, and reversible topotactic transformations

J. Gougoutas, 1977 .

Substitution of lysine at position 104 or 240 of TEM-1pTZ18R beta-lactamase enhances the effect of serine-164 substitution on hydrolysis or affinity for cephalosporins and the monobactam aztreonam.

T J Dougherty, S. B. Singer, T. Dougherty, 1991, Biochemistry.

Monocapped tris(dioxime) complexes of technetium(III): synthesis and structural characterization of TcX(dioxime)3B-R (X = Cl, Br; dioxime = dimethylglyoxime, cyclohexanedione dioxime; R = CH3, C4H9)

A. Nunn, L. Francesconi, M. Malley, 1989 .

Conformationally constrained calcium channel blockers: novel mimics of 1-benzazepin-2-ones.

S. Spergel, J. Barrish, S. Moreland, 1993, Bioorganic & medicinal chemistry.

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

P. M. Davis, V. Goldfarb, D. Cheney, 2006, Journal of medicinal chemistry.

High Conductivity Solid Electrolytes Double Salts of Substituted Organic Ammonium Halides and Cuprous Halides

A. Sammells, B. Owens, J. Gougoutas, 1975 .

Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.

Haixia Wang, Stanley R Krystek, Jacek Ostrowski, 2007, Journal of medicinal chemistry.

The crystal and molecular structures of (a) 2,2'-diiodo- (b) 2,2'-dibromo- (c) 2,2'-dichloro- (d) 2-iodo-2'-bromo- and (e) 2-iodo-2'-chlorodibenzoyl peroxides

J. Clardy, J. Gougoutas, 1970 .

An Alternate Route to 2-Amino-3-nitro-5-bromo-4-picoline: Regioselective Pyridine Synthesis via 2-Nitramino-picoline Intermediate

V. Purohit, J. Gougoutas, A. Bhattacharya, 2007 .

SULFENYL TRANSFER REARRANGEMENT OF SULFENIMINES (THIOOXIMES). A NOVEL SYNTHESIS OF 7α-METHOXYCEPHALOSPORINS AND 6α-METHOXYPENICILLINS

E. Gordon, H. W. Chang, C. Cimarusti, 1980 .

Solid state chemistry of organic polyvalent iodine compounds. II. The crystal structure of 2-iodo-3′-chlorodibenzoyl peroxide

J. Gougoutas, L. Lessinger, 1973 .

Novel heterocycle. Crystal structure and formation of N-chloro-3-aza-3H,2,1-benzoxiodol-1-yl chloride from the dichloride of o-iodobenzamide

J. Gougoutas, D. Naae, 1975 .

Templates and Twinning in Topotaxy

J. Gougoutas, 1972 .

Solid-state chemistry of organic polyvalent iodine compounds. I. The crystal structures of two polymorphs of 1-(2′-iodobenzoyloxy)-1,2-benziodoxolin-3-one

J. Clardy, J. Gougoutas, 1972 .

Solid-state chemistry of organic polyvalent iodine compounds. V. The crystal structures of 3-oxo-3H-2,1-benzoxiodol-1-yl o-bromobenzoate (two polymorphs) and 3-oxo-3H-2,1-benzoxiodol-1-yl o-chlorobenzoate

J. Gougoutas, D. Naae, 1976 .

Solid state chemistry of organic polyvalent iodine compounds. III. The crystal structures of 3-oxo-3H-2,1-benzoxiodol-1-yl m-chlorobenzoate (two polymorphs) and its isostructural derivative, 3-oxo-3H-2,1-benzoxiodol-1-yl benzoate

J. Gougoutas, L. Lessinger, 1974 .

Solid state chemistry of organic polyvalent iodine compounds. IV. Topotactic transformations of 2-iodo-3′-chlorodibenzoyl peroxide and the crystal structure of m-chlorobenzoic acid

J. Gougoutas, L. Lessinger, 1975 .

A NOVEL HETEROCYCLE, CRYSTAL STRUCTURE AND FORMATION OF N-CHLORO-3-AZA-3H,2,1-BENZOXIODOL-1-YL CHLORIDE FROM THE DICHLORIDE OF O-IODOBENZAMIDE

J. Gougoutas, D. Naae, 2002 .

Technetium, rhenium and manganese bamo (boronic acid adducts of metal oxime) complexes: Similarities and differences

A. Nunn, S. Jurisson, K. Linder, 1989 .

Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.

R. Parker, L. Hamann, D. Augeri, 2004, Journal of medicinal chemistry.

Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.

E. Liu, P. Stein, D. Floyd, 1995, Journal of medicinal chemistry.

X-RAY AND THEORETICAL ANALYSIS OF THE RELATIONSHIP BETWEEN SUBSTITUENT STERIC EFFECTS AND THE STRUCTURE OF BICYCLO(1.1.0)BUTANE. THE UNEXPECTED FLEXIBILITY OF THE BICYCLO(1.1.0)BUTANE SKELETON

P. G. Gassman, D. Dixon, S. Richtsmeier, 1983 .

X-ray and theoretical analysis of the relationship between substituents steric effects and the structure of bicyclo[1.1.0]butane: the unexpected flexibility of the bicyclo[1.1.0]butane skeleton

P. G. Gassman, D. Dixon, S. Richtsmeier, 1983 .

1,2,4-Triazolo- and 1,2,5-triazino[4,3-d][1,4]benzodiazepinone ring systems: synthesis and barrier to ring inversion

M. Puar, J. Gougoutas, B. Toeplitz, 1979 .

Neutral, seven-coordinate dioxime complexes of technetium(III): synthesis and characterization

A. Nunn, K. Linder, S. Unger, 1990 .

DIELS-ALDER REACTIONS INVOLVING HETEROCYCLIC DIENOPHILES. SYNTHESIS OF SUBSTITUTED HYDROQUINAZOLINES AND 1,3-DIAZASPIRO(4.5)DECADIENES

J. Bland, J. Keana, J. Gougoutas, 1976 .

Diels-Alder reactions involving heterocyclic dienophiles. Synthesis of substituted hydroquinazolines and 1,3-diazaspiro[4.5]decadienes

J. Bland, J. Keana, J. Gougoutas, 1976 .

The structure of tetrodotoxin

R. Woodward, J. Gougoutas, R. B. Woodward, 1964 .

Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.

W. R. Ewing, M. Pelleymounter, Qi Huang, 2011, European journal of pharmacology.