S. Lusher

发表

X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids

R. McGuire, K. Dechering, H. Hamersma, 2012, The Journal of Biological Chemistry.

Drug Design Approaches to Manipulate the Agonist-Antagonist Equilibrium in Steroid Receptors

J. D. Vlieg, W. Dokter, P. Hermkens, 2012 .

Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators

R. McGuire, K. Dechering, J. de Vlieg, 2011, The Journal of Biological Chemistry.

The FAIR Guiding Principles for scientific data management and stewardship

Erik Schultes, Albert Mons, Barend Mons, 2016, Scientific Data.

Systematic Structure-Function Analysis of Androgen Receptor Leu701 Mutants Explains the Properties of the Prostate Cancer Mutant L701H*

Guido Jenster, Hendrikus J Dubbink, Scott J Lusher, 2009, The Journal of Biological Chemistry.

Variable Loss of Functional Activities of Androgen Receptor Mutants in Patients with Androgen Insensitivity Syndrome

A. Houtsmuller, J. Trapman, M. V. van Royen, 2013, Sexual Development.

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.

Mark A. Weston, M. Ohlmeyer, F. Thomson, 2011, Bioorganic & medicinal chemistry letters.

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics.

L. Brunsveld, J. de Vlieg, S. Möcklinghoff, 2009, Chemical communications.

A molecular informatics view on best practice in multi-parameter compound optimization.

Ross McGuire, Jan-Willem Boiten, Scott J Lusher, 2011, Drug discovery today.

Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

R. McGuire, W. Alkema, A. Grefhorst, 2012, PloS one.

Addendum: The FAIR Guiding Principles for scientific data management and stewardship

Alasdair J. G. Gray, Paul T. Groth, Philip E. Bourne, 2019, Scientific Data.

Data-driven medicinal chemistry in the era of big data.

Ross McGuire, Jacob de Vlieg, Scott J. Lusher, 2014, Drug discovery today.

All scientific disciplines, including medicinal chemistry, are the subject of a revolution as data are generated at unprecedented rates and their analysis and exploitation become increasingly fundamental to innovation. Data-driven medicinal chemistry in the era of big data

Ross McGuire, Scott J. Lusher, C. David Nicholson, 2014 .

The Need of Industry to Go FAIR

Luiz Olavo Bonino da Silva Santos, Albert Mons, Bert Meerman, 2020, Data Intelligence.

Non-steroidal steroid receptor modulators.

G. Veeneman, P. Hermkens, S. Lusher, 2006, IDrugs : the investigational drugs journal.

3D-e-Chem-VM: Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine

Lars Ridder, Chris de Graaf, Tina Ritschel, 2017, J. Chem. Inf. Model..

Addendum: The FAIR Guiding Principles for scientific data management and stewardship

Paul T. Groth, Mark D. Wilkinson, Alejandra N. González-Beltrán, 2019, Scientific Data.