P. Tracy

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Both Cellular and Soluble Forms of Thrombomodulin Inhibit Fibrinolysis by Potentiating the Activation of Thrombin-activable Fibrinolysis Inhibitor*

J. Morser, M. Nesheim, L. Bajzar, 1998, The Journal of Biological Chemistry.

The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent.

M. Nesheim, L. Bajzar, P. Tracy, 1996, Blood.

Kinetics of inactivation of membrane-bound factor Va by activated protein C. Protein S modulates factor Xa protection.

M. Tucker, P. Tracy, S. Solymoss, 1988, The Journal of biological chemistry.

Endotoxin enhances the expression of monocyte prothrombinase activity.

P. Tracy, R. Robinson, L. Worfolk, 1992, Blood.

Human prothrombinase complex assembly and function on isolated peripheral blood cell populations.

K. Mann, P. Tracy, L. Eide, 1985, The Journal of biological chemistry.

CHAPTER 19 – Interactions Between Platelets and the Coagulation System

K. Mann, S. Butenas, B. Bouchard, 2007 .

Acute coronary syndromes: 2. Antiplatelet agents.

B. Sobel, D. Schneider, P. Tracy, 1998, Hospital practice.

Proteolytic alterations of factor Va bound to platelets.

K. Mann, M. Nesheim, P. Tracy, 1983, The Journal of biological chemistry.

Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C.

P. Simioni, A. Girolami, R. Camire, 1998, Blood.

The Mechanism of Inactivation of Human Platelet Factor Va from Normal and Activated Protein C-resistant Individuals (*)

K. Mann, M. Cushman, R. Tracy, 1995, The Journal of Biological Chemistry.

Thrombolytic therapy and proteolysis of factor V.

K. Mann, R. Tracy, M. Rand, 1997, Journal of the American College of Cardiology.

Plasma lipoproteins support prothrombinase and other procoagulant enzymatic complexes.

K. Mann, R. Tracy, M. Moyer, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Mathematical simulation of prothrombinase.

K. Mann, R. Tracy, M. Nesheim, 1992, Methods in enzymology.

Platelets: Developmental biology, physiology, and translatable platforms for preclinical investigation and drug development

Sunil V. Rao, S. Steinhubl, J. Freedman, 2008, Platelets.

Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium.

J. White, J. L. Goodman, G. Vercellotti, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Prothrombin Activation by Platelet-associated Prothrombinase Proceeds through the Prethrombin-2 Pathway via a Concerted Mechanism*

K. Mann, B. Bouchard, P. Tracy, 2012, The Journal of Biological Chemistry.

Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity.

J. Silveira, P. Tracy, J. Wood, 2011, Blood.

Factor Xa interacts with two sites on monocytes with different functional activities.

P. Tracy, R. Robinson, L. Worfolk, 1992, Blood.

Platelet factor Xa receptor.

K. Mann, M. Nesheim, P. Tracy, 1992, Methods in enzymology.

The isolation of human platelet factor V.

K. Mann, P. Tracy, R. Viskup, 1987, Blood.

Abnormal formation of the prothrombinase complex: factor V deficiency and related disorders.

K. Mann, P. Tracy, 1987, Human pathology.

7 – A Model for Assembly of Coagulation Factor Complexes on Cell Surfaces: Prothrombin Activation on Platelets

P. Tracy, 1986 .

Chapter 2A Nonenzymatic cofactors: factor V*

K. Mann, M. Nesheim, P. Tracy, 1986 .

Assembly of the prothrombinase complex.

K. Mann, L. Hibbard, J. Bloom, 1982, Biophysical journal.

Radioimmunoassay of factor V in human plasma and platelets.

K. Mann, E. Bowie, P. Tracy, 1982, Blood.

An Antifibrinolytic Mechanism Describing the Prothrombotic Effect Associated with Factor VLeiden*

P. Simioni, M. Kalafatis, L. Bajzar, 1996, The Journal of Biological Chemistry.

Proteolysis of plasma‐derived factor V following its endocytosis by megakaryocytes forms the platelet‐derived factor V/Va pool

S. Abdalla, B. Bouchard, P. Tracy, 2013, Journal of thrombosis and haemostasis : JTH.

Endocytosis of plasma‐derived factor V by megakaryocytes occurs via a clathrin‐dependent, specific membrane binding event

M. Long, N. Meisler, B. Bouchard, 2005, Journal of thrombosis and haemostasis : JTH.

Platelets, leukocytes, and coagulation

B. Bouchard, P. Tracy, 2001, Current opinion in hematology.

Human Coagulation Factor V Is Activated to the Functional Cofactor by Elastase and Cathepsin G Expressed at the Monocyte Surface (*)

P. Tracy, D. H. Allen, 1995, The Journal of Biological Chemistry.

Procoagulant activities expressed by peripheral blood mononuclear cells.

P. Tracy, R. Robinson, L. Worfolk, 1993, Methods in enzymology.

Effects of nutritional folate deficiency on the adhesive properties of murine melanoma cells.

R. Branda, P. Tracy, 1990, Cancer letters.

Tumor cell generation of thrombin via functional prothrombinase assembly.

K. Mann, H. Dvorak, P. Tracy, 1985, Cancer research.

Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet‐derived cofactor

P. Simioni, D. Tormene, J. Silveira, 2005, Journal of thrombosis and haemostasis : JTH.

Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin.

P. Tracy, D. Monković, D. Monkovic, 1990, The Journal of biological chemistry.

Coordinate binding of factor Va and factor Xa to the unstimulated platelet.

K. Mann, M. Nesheim, P. Tracy, 1981, The Journal of biological chemistry.

Unexpected, Discordant Effects of Aspirin on Platelet Reactivity

B. Sobel, D. Schneider, P. Tracy, 1998 .

Acute coronary syndromes: 1. The platelet's role.

B. Sobel, D. Schneider, P. Tracy, 1998, Hospital practice.

Total Retention Liquid Chromatography-Mass Spectrometry to Achieve Maximum Protein Sequence Coverage.

D. Matthews, J. Silveira, P. Tracy, 2021, Analytical chemistry.

Regulation of Thrombin Generation at Cell Surfaces

P. Tracy, 1988, Seminars in thrombosis and hemostasis.

Human brain pericytes differentially regulate expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood coagulation.

B. Bouchard, P. Tracy, M. Shatos, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Functional prothrombinase complex assembly on isolated monocytes and lymphocytes.

K. Mann, M. Rohrbach, P. Tracy, 1983, The Journal of biological chemistry.

Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency.

N. Key, P. Durda, J. Chapin, 2015, Blood.

A unique function for LRP‐1: a component of a two‐receptor system mediating specific endocytosis of plasma‐derived factor V by megakaryocytes

D. Strickland, M. Nesheim, N. Meisler, 2008, Journal of thrombosis and haemostasis : JTH.

Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va.

K. Mann, P. Tracy, 1983, Proceedings of the National Academy of Sciences of the United States of America.

RAPID COMMUNICATION Factor V Quebec Revisited

K. Mann, G. Rivard, P. Tracy, 2016 .

Factor V Quebec revisited.

K. Mann, G. Rivard, P. Tracy, 1996, Blood.

Molecular weight of undegraded plasma factor V.

K. Mann, M. Nesheim, P. Tracy, 1981, Biochemistry.

Factor V.

K. Mann, J. Katzmann, M. Nesheim, 1981, Methods in enzymology.

Proteolysis of factor V by cathepsin G and elastase indicates that cleavage at Arg1545 optimizes cofactor function by facilitating factor Xa binding.

R. Camire, M. Kalafatis, P. Tracy, 1998, Biochemistry.

The coagulant-active phospholipid content is a major determinant of in vivo thrombogenicity of prothrombin complex (Factor IX) concentrates in rabbits.

K. Mann, A. Giles, M. Nesheim, 1982, Blood.

Activation of human factor V by factor Xa and thrombin.

D D Monkovic, P B Tracy, P. Tracy, 1990, Biochemistry.

The participation of leukocytes in coagulant reactions

B. Bouchard, P. Tracy, 2003, Journal of thrombosis and haemostasis : JTH.

Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation

Susan A Maroney, R. Camire, A. Mast, 2013, Proceedings of the National Academy of Sciences.

Unique in Vivo Modifications of Coagulation Factor V Produce a Physically and Functionally Distinct Platelet-derived Cofactor

J. Silveira, P. Tracy, W. R. Gould, 2004, Journal of Biological Chemistry.

Stroma free human platelet lysates potentiate the in vivo thrombogenicity of factor Xa by the provision of coagulant‐active phospholipid

K. Mann, A. Giles, M. Nesheim, 1982, British journal of haematology.

Interaction of coagulation factor V and factor Va with platelets.

K. Mann, M. Nesheim, J. Peterson, 1979, The Journal of biological chemistry.

Interactions Between Platelets and the Coagulation System

Beth A. Bouchard, J. Silveira, Jay R. Silveira, 2013 .

Response of protein C and protein C inhibitor to warfarin therapy in patient with combined deficiency of Factors V and VIII.

C. Arkin, L. Hoyer, K. Suzuki, 1984, Thrombosis research.

[21] Factor V

K. Mann, J. Katzmann, M. Nesheim, 1981 .

The Platelet High Affinity Binding Site for Thrombin Mimics Hirudin, Modulates Thrombin-induced Platelet Activation, and Is Distinct from the Glycoprotein Ib-IX-V Complex*

P. Tracy, K. L. Hayes, 1999, The Journal of Biological Chemistry.

Properties of Procoagulant Platelets: Defining and Characterizing the Subpopulation Binding a Functional Prothrombinase*

A. M. Fager, B. Bouchard, P. Tracy, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Intact platelet membranes, not platelet-released microvesicles, support the procoagulant activity of adherent platelets.

K. Mann, P. Tracy, N. A. Swords, 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

alpha-Thrombin-induced human platelet activation results solely from formation of a specific enzyme-substrate complex.

L. Leong, R. Henriksen, L. Ouellette, 1994, The Journal of biological chemistry.

Differential effects of anticoagulants on the activation of platelets ex vivo.

K. Mann, B. Sobel, D. Schneider, 1997, Circulation.

THE ROLE OF FACTOR V IN THE ASSEMBLY OF THE PROTHROMBINASE COMPLEX *

K. Mann, L. Hibbard, M. Nesheim, 1981, Annals of the New York Academy of Sciences.

On the Role of EPR-1 or an EPR-1-like Molecule in Regulating Factor Xa Incorporation into Platelet Prothrombinase

J. Silveira, B. Bouchard, P. Tracy, 2001, Thrombosis and Haemostasis.

Effector Cell Protease Receptor-1, a Platelet Activation-dependent Membrane Protein, Regulates Prothrombinase-catalyzed Thrombin Generation*

C. Adida, B. Bouchard, P. Tracy, 1997, The Journal of Biological Chemistry.

Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.

K. Mann, A. Giles, G. Rivard, 1984, The Journal of clinical investigation.

Platelet-Derived Factor Va Expressed on the Surface of the Activated Platelet Is GPI-Anchored

A. M. Fager, J. Silveira, P. Tracy, 2008 .

New views on the relationship of plasma lipids to cardiovascular disease.

R. Tracy, P. Tracy, 1997, Circulation.

Adenosine Diphosphate–Induced Platelet Activation Inhibited by Magnesium in a Dose‐Dependent Manner

E. Capeless, Eleanor L. Capeless, M. Meyer, 1998, Obstetrics and gynecology.

Secretable human platelet-derived factor V originates from the plasma pool.

K. Kaushansky, R. Camire, E. Pollak, 1998, Blood.

Monocyte/macrophage regulation of coagulant events.

P. Tracy, L. Worfolk, D. H. Allen, 1996, Haemostasis.

Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles.

K. High, P. Larson, R. Camire, 1998, Biochemistry.

Short title: Musunuru et al; Design of NHLBI CARe

Marcia M. Nizzari, M. Fornage, S. Gabriel, 2017 .

The factor V light chain mediates the binding and endocytosis of plasma‐derived factor V by megakaryocytes

S. Abdalla, B. Bouchard, P. Tracy, 2013, Journal of thrombosis and haemostasis : JTH.

Platelet regulation of thrombin generation in cardiovascular disease.

B. Bouchard, P. Tracy, 2001, Italian heart journal : official journal of the Italian Federation of Cardiology.

91. Factor Va plays a major role in determining the fibrinolytic potential of a clot

P. Simioni, M. Kalafatis, L. Bajzar, 1996 .

Proteolysis of plasma‐derived factor V following its endocytosis by megakaryocytes forms the platelet‐derived factor V/Va pool

B. Bouchard, P. Tracy, Francis Ayombil, 2013, Journal of thrombosis and haemostasis : JTH.

Prothrombin Activation by Platelet-associated Prothrombinase Proceeds through the Prethrombin-2 Pathway via a Concerted Mechanism*

K. Mann, B. Bouchard, P. Tracy, 2012, The Journal of Biological Chemistry.

The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins, Quick I and Quick II.

L. Leong, R. Henriksen, J. Kermode, 1992, Biochemistry.

A case of acquired factor X deficiency with in vivo and in vitro evidence of inhibitor activity directed against factor X.

R. Branda, E. Bovill, P. Tracy, 1991, American journal of clinical pathology.

Interaction of Factor V and Factor Va with Platelets

K. Mann, M. Nesheim, J. Peterson, 1979, Thrombosis and Haemostasis.