P. Sims

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Embryopathic Effects of 7,12-Dimethylbenz(a)anthracene and its Hydroxymethyl Derivatives in the Sprague–Dawley Rat

C. Bird, A. Currie, A. Crawford, 1970, Nature.

The metabolism of benzo[a]pyrene by rat-liver homogenates.

P. Sims, 1967, Biochemical pharmacology.

Reactions of polycyclic hydrocarbon epoxides with RNA and polyribonucleotides.

P. Grover, P. Sims, A. Swaisland, 1974, Chemico-biological interactions.

Metabolism and activation of carcinogenic polycyclic hydrocarbons by human mammary cells.

A. Neville, A. MacNicoll, P. Grover, 1980, Biochemical and biophysical research communications.

Metabolism of polycyclic compounds. 26. The hydroxylation of some aromatic hydrocarbons by the ascorbic acid model hydroxylating system and by rat-liver microsomes.

E. Boyland, P. Sims, M. Kumura, 1964, The Biochemical journal.

Metabolism of polycyclic compounds. 17. The reaction of 1:2-dihydronaphthalene and 1:2-epoxy-1:2:3:4-tetrahydronaphthalene with glutathione catalysed by tissue preparations.

T. Sato, E. Boyland, P. Sims, 1960, The Biochemical journal.

An enzyme from rat liver catalysing conjugations with glutathione.

E. Boyland, P. Sims, J. Booth, 1961, The Biochemical journal.

The covalent binding of polycyclic hydrocarbons to DNA in the skin of mice of different strains

D. Phillips, P. Grover, P. Sims, 1978, International journal of cancer.

3 – Involvement of Dihydrodiols and Diol Epoxides in the Metabolic Activation of Polycyclic Hydrocarbons Other than Benzo[a]pyrene

P. Grover, P. Sims, 1981 .

Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro.

P. Grover, P. Sims, P. Grover, 1968, The Biochemical journal.

K‐region epoxides of polycyclic hydrocarbons: Formation and further metabolism of benz[a] anthracene 5, 6‐oxide by human lung preparations

A. Hewer, P. Grover, P. Sims, 1973, FEBS letters.

Glutathione S-transferase activity towards benz[a]anthracene 5,6-oxide in the liver, kidney and lung of cynomolgus monkeys.

L. F. Chasseaud, P. Sims, W. Down, 1980, Biochemical pharmacology.

Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons.

C. Heidelberger, J. Selkirk, T. Kuroki, 1972, Cancer research.

Glutathione conjugates as metabolites of benz[a]anthracene.

P. Sims, J. Booth, G. Keysell, 1975, Xenobiotica; the fate of foreign compounds in biological systems.

Studies on the formation of hydrocarbon-deoxyribonucleoside products by the binding of derivatives of 7-methylbenz(a)anthracene to DNA in aqueous solution and in mouse embryo cells in culture.

A. Dipple, W. Baird, P. Grover, 1973, Cancer research.

Binding of K-region epoxides and other derivatives of benz(a)anthracene and dibenz(a,h)anthracene to DNA, RNA, and proteins of transformable cells.

C. Heidelberger, J. Selkirk, T. Kuroki, 1972, Chemico-biological interactions.

Epoxides as microsomal metabolites of polycyclic hydrocarbons

A. Hewer, P. Grover, P. Sims, 1971, FEBS letters.

Conjugations with glutathione. Distribution of glutathione S-aryltransferase in vertebrate species.

P. Grover, P. Sims, 1964, The Biochemical journal.

A quantitative determination of the covalent binding of a series of polycylic hydrocarbons to dna in mouse skin

P. Grover, P. Sims, David H. Pcchillips, 1979, International journal of cancer.

The metabolic activation of 7-methylbenz(a)anthracene in mouse skin.

C. Walsh, A. Hewer, P. Grover, 1977, Chemico-biological interactions.

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100.

H. Bartsch, C. Malaveille, P. Grover, 1975, Biochemical and biophysical research communications.

Metabolism and activation of benzo[a]pyrene by mouse and rat skin in short-term organ culture and in vivo.

A. Weston, P. Grover, P. Sims, 1982, Chemico-biological interactions.

The formation of dihydrodiols by the chemical or enzymic oxidation of 7-hydroxymethyl-12-methylbenz[alpha]anthracene and the possible role of hydroxymethyl dihydrodiols in the metabolic activation of 7,12-dimethylbenz[alpha]anthracene.

A. Hewer, A. MacNicoll, P. Grover, 1979, Chemico-biological interactions.

Mutagenicity of epoxides of polycyclic hydrocarbons correlates with carcinogenicity of parent hydrocarbons.

P. Grover, P. Sims, M. Cookson, 1971, Nature: New biology.

The enzyme-catalysed conversion of anti-benzo[a]pyrene-7,8-diol 9,10-oxide into a glutathione conjugate.

A. Hewer, P. Sims, C. S. Cooper, 1980, Carcinogenesis.

Metabolism of polycyclic compounds. 23. The metabolism of pyrene in rats and rabbits.

E. Boyland, P. Sims, 1964, The Biochemical journal.

Metabolic activation of 3-methylcholanthrene in mouse skin: fluorescence spectral evidence indicates the involvement of diol-epoxides formed in the 7,8,9,10-ring.

P. Vigny, C. S. Cooper, P. Grover, 1980, Carcinogenesis.

The involvement of a 'bay-region' and a non-'bay-region' diol-epoxide in the metabolic activation of benz[a]anthracene in mouse skin and in hamster embryo cells.

C. Walsh, A. Hewer, C. S. Cooper, 1980, Carcinogenesis.

The metabolism of a series of polycyclic hydrocarbons by mouse skin maintained in short-term organ culture.

A. MacNicoll, P. Grover, P. Sims, 1980, Chemico-biological interactions.

The initiation of tumours on mouse skin by dihydrodiols derived from 7,12‐dimethylbenz(a)anthracene and 3‐methylcholanthrene

P. Grover, I. Chouroulinkov, P. Sims, 1979, International journal of cancer.

Induction of malignant transformation and mutagenesis by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene.

H. Marquardt, P. Grover, P. Sims, 1978, Biochemical and biophysical research communications.

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene.

P. Grover, I. Chouroulinkov, P. Sims, 1976, British Journal of Cancer.

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

A. Hewer, P. Grover, P. Sims, 1974, Nature.

High-performance liquid chromatography of isomeric-dihydrodiols of polycyclic hydrocarbons

C. Walsh, A. Hewer, P. Grover, 1979 .

DNA Binding and Polycyclic Hydrocarbon Carcinogenesis

P. Grover, P. Sims, 1979 .

Some properties of vicinal diol-epoxides derived from benzo(a)anthracene and benzo(a)pyrene.

D. Phillips, P. Grover, P. Sims, 1978, Chemico-biological interactions.

Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells.

H. Bartsch, T. Kuroki, P. Sims, 1977, Mutation research.

Malignant transformation and mutagenesis in mammalian cells induced by vicinal diol-epoxides derived from benzo(a)pyrene.

H. Marquardt, P. Grover, P. Sims, 1977, Cancer letters.

The involvement of a diol‐epoxide in the metabolic activation of benzo(a)pyrene in human bronchial mucosa and in mouse skin

A. Hewer, P. Grover, P. Sims, 1976, International journal of cancer.

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz( )anthracene 8,9-oxide and 10,11-dihydrobenz( )anthracene 8,9-oxide and their metabolism by rat liver preparations.

P. Sims, 1971, The Biochemical journal.

Formation of K-region epoxides as microsomal metabolites of pyrene and benzo(a)pyrene.

A. Hewer, P. Grover, P. Sims, 1972, Biochemical pharmacology.

METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 9,10-EPOXY-9,10-DIHYDROPHENANTHRENE IN RATS.

E. Boyland, P. Sims, 1965, The Biochemical journal.

The metabolism of 9,10-dimethylanthracene by rat liver microsomal preparations.

P. Cary, P. Farmer, H. Lamparczyk, 1984, Carcinogenesis.

Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons.

C. Heidelberger, E. Huberman, P. Grover, 1971, Proceedings of the National Academy of Sciences of the United States of America.

In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.

C. Heidelberger, T. Kuroki, E. Huberman, 1971, Proceedings of the National Academy of Sciences of the United States of America.

The carcinogenic activities in mice of compounds related to benz[a]anthracene

E. Boyland, P. Sims, 1967, International journal of cancer.

The metabolism of benz[a]anthracene and dibenz[a,h]anthracene and their 5,6-epoxy-5,6-dihydro derivatives by rat-liver homogenates.

E. Boyland, P. Sims, 1965, The Biochemical journal.

Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations.

P. Sims, 1970, Biochemical pharmacology.

729. The preparation of o-aminophenyl sulphates

E. Boyland, P. Sims, D. Manson, 1953 .

New metabolites in isovaleric acidemia.

W. Nyhan, D. Danks, J. Hammond, 1981, Clinica chimica acta; international journal of clinical chemistry.

Induction of sister-chromatid exchanges in Chinese hamster ovary cells treated in vitro with non-K-region dihydrodiols of 7-methylbenz[a]anthracene and benzo[a]pyrene.

P. Grover, P. Sims, B. Tierney, 1978, Mutation research.

Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.

P. Grover, P. Sims, 1974, Advances in cancer research.

Studies on the metabolism of 7-methylbenz-[a]anthracene and 7,12-dimethylbenz[1]anthracene and its hydroxymethyl derivatives in rat liver and adrenal homogenates.

P. Sims, 1970, Biochemical pharmacology.

The metabolism of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by rat liver and adrenal homogenates and by rat adrenocortical cells.

D. Phillips, W. Swallow, P. Grover, 1983, Chemico-biological interactions.

The metabolism of 7,12-dimethylbenz (a) anthracene by homogenates of the stomach and small intestine of mice

P. Sims, A. Gentil, 2004, Zeitschrift für Krebsforschung und Klinische Onkologie.

The metabolism of 9-methylanthracene by rat-liver microsomal preparations.

P. Cary, P. Farmer, H. Lamparczyk, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

The formation of dihydrodiols by the chemical or enzymic oxidation of benz[a] anthracene and 7,12-dimethylbenz[a] anthracene.

C. Walsh, A. Hewer, P. Giovanni Gervasi, 1978, Chemico-biological interactions.

Microsome-mediated mutagenicities of the dihydrodiols of 7,12-dimethylbenz[a]anthracene: high mutagenic activity of the 3,4-dihydrodiol.

H. Bartsch, C. Malaveille, P. Grover, 1978, Biochemical and biophysical research communications.

The metabolic activation of 7‐methylbenz(a)anthracene: The induction of malignant transformation and mutation in mammalian cells by non‐K‐region dihydrodiols

P. Sims, H. Marquardt, P. Grover, 1977, International journal of cancer.

High microsome-mediated mutagenicity of the 3,4-dihydrodiol of 7-methylbenz[a]anthracene in S. typhimurium TA 98.

H. Bartsch, C. Malaveille, P. Grover, 1977, Biochemical and biophysical research communications.

The activity of 7-methylbenz(a)anthracene metabolites in an in vitro-in vivo carcinogenicity test using mouse lung tissue.

P. Sims, A. Flaks, 1977, Cancer letters.

Metabolism of benz(a)anthracene epoxides by rat-liver.

P. Sims, J. Booth, 1974, Biochemical pharmacology.

Effect of oestradiol on the in vitro metabolism of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives.

P. Sims, J. Booth, G. Keysell, 1974, Biochemical pharmacology.

The formation of "K-region" epoxides as hepatic microsomal metabolites of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and their 7-hydroxymethyl derivatives.

A. Hewer, P. Sims, J. Booth, 1973, Biochemical pharmacology.

Formation of glutathione conjugates as metabolites of 7,12-dimethylbenz-(a)anthracene by rat-liver homogenates.

P. Sims, J. Booth, G. Keysell, 1973, Biochemical pharmacology.

Evaluation of the carcinogenic activity of the hydroxymethyl derivatives of 7,12‐dimethylbenz(A) anthracene by an in vitro‐in vivo technique

D. Clayson, P. Sims, J. M. Hamilton, 1972, International journal of cancer.

The preparation of 7-hydroxymethylbenz(a)anthracene 5,6-oxide and its metabolism by rat-liver preparations.

P. Sims, 1972, Xenobiotica; the fate of foreign compounds in biological systems.

Comparison of the efficacy of pretreatment protection against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and by 7-methyl-12-methylbenz(a)anthracene in rats.

D. Wheatley, P. Sims, 1969, Biochemical pharmacology.

Quantitative aspects of the metabolism of 7, 12-dimethylbenz[a]anthracene by liver homogenates from animals of different age, sex and species.

P. Grover, P. Sims, 1968, Biochemical pharmacology.

The metabolism of 7- and 12-methylbenz[a]anthracene and their derivatives.

P. Sims, 1967, The Biochemical journal.

The effect of pretreatment with adrenal-protecting compounds on the metabolism of 7,12-dimethylbenz[a]anthracene and related compounds by rat-liver homogenates.

E. Boyland, P. Sims, 1967, The Biochemical journal.

Adrenal Necrosis induced by 7-Hydroxymethyl-12-methylbenz(a)anthracene and its Prevention

D. Wheatley, A. Currie, E. Boyland, 1966, Nature.

Induction of Adrenal Damage and Cancer with Metabolites of 7,12-Dimethylbenz(a)Anthracene

C. Huggins, E. Boyland, P. Sims, 1965, Nature.

METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.

E. Boyland, P. Sims, 1965, The Biochemical journal.

Interactions of the K-region epoxides of phenanthrene and dibenz (a,h)anthracene with nucleic acids and histone.

P. Grover, P. Sims, 1970, Biochemical pharmacology.

461. Unsaturated lactones and related substances. Part IV. Lactonic products derived from muconic acid

B. Orkin, R. Linstead, H. Baer, 1950 .

Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens

B. Ames, P. Grover, P. Sims, 1972, Science.

The biochemistry of aromatic amines; the resistance of some o-aminoaryl sulphates to hydrolysis by aryl sulphatases.

D. Williams, E. Boyland, P. Sims, 1956, The Biochemical journal.

The oxidation of some aromatic amines with persulphate

E. Boyland, P. Sims, 1954 .

The oxidation of tryptophan and some related compounds with persulphate.

D. Williams, E. Boyland, P. Sims, 1956, The Biochemical journal.

462. The third isomeric (cis-trans-) muconic acid

B. Orkin, R. Linstead, P. Sims, 1950 .

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to benzo(a)pyrene and to 7,8- and 9,10-dihydrobenzo(a)pyrene.

P. Sims, J. F. Waterfall, 1972, The Biochemical journal.

Fluorescence spectral evidence that benzo(a)pyrene‐DNA products in mouse skin arise from diol‐epoxides

P. Vigny, P. Grover, P. Sims, 1975, FEBS letters.

Metabolism of polycyclic compounds. 20. The metabolism of phenanthrene in rabbits and rats: mercapturic acids and related compounds.

E. Boyland, P. Sims, 1962, The Biochemical journal.

Effect of DNA repair on the cytotoxicity and mutagenicity of polycyclic hydrocarbon derivatives in normal and xeroderma pigmentosum human fibroblasts.

J. Mccormick, V. Maher, P. Grover, 1977, Mutation research.

Tumour-initiating activities of dihydrodiols of dibenz[a,c]anthracene.

A. MacNicoll, P. Grover, H. Coulomb, 1983, Cancer letters.

Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene.

H. Marquardt, P. Grover, P. Sims, 1979, British Journal of Cancer.

Microsomal and nuclear metabolism of 3-methylcholanthrene.

E. Bresnick, P. Sims, B. Tierney, 1979, Biochemical pharmacology.

The formation of dihydrodiols by chemical or enzymic oxidation of 3-methylcholanthrene.

A. Hewer, P. Grover, P. Sims, 1978, Chemico-biological interactions.

The metabolism of 3-methylcholanthrene and some related compounds by rat-liver homogenates.

P. Sims, 1966, The Biochemical journal.

Metabolic activation of 3-methylcholanthrene: mutagenic and transforming activities of the 9,10-dihydrodiol.

H. Bartsch, A. Hewer, H. Marquardt, 1978, Biochemical and biophysical research communications.

The metabolic activation of benz[a]anthracene in hamster embryo cells: evidence that diol-epoxides react with guanosine, deoxyguanosine and adenosine in nucleic acids.

C. Walsh, A. Hewer, P. Farmer, 1980, Chemico-biological interactions.

Metabolic activation of benzo[a]pyrene in human skin maintained in short-term organ culture.

A. Weston, P. Grover, P. Sims, 1983, Chemico-biological interactions.

The metabolic activation of benz[alpha]anthracene in three biological systems.

A. Hewer, C. S. Cooper, A. MacNicoll, 1981, Cancer letters.

The involvement of a non-'bay-region' diol-epoxide in the metabolic activation of benza[a]anthracene in hamster embryo cells.

C. Walsh, A. Hewer, P. Gervasi, 1980, Cancer letters.

Dihydrodiols and Diol-Epoxides in the Activation and Detoxification of Polycyclic Hydrocarbons

P. Sims, 1980 .

8,9‐Dihydro‐8,9‐dihydroxybenz(a)anthracene 10,11‐oxide: A new type of polycyclic aromatic hydrocarbon metabolite

P. Sims, J. Booth, 1974, FEBS letters.

Polycyclic hydrocarbon epoxides: The involvement of 8,9‐dihydro‐8,9‐dihydroxybenz (a) anthracene 10,11‐oxide in reactions with the DNA of benz (a) anthracene‐treated hamster embryo cells

A. Hewer, P. Grover, P. Sims, 1974, FEBS letters.

Metabolism of polycyclic compounds. 24. The metabolism of benz[α]anthracene

E. Boyland, P. Sims, 1964 .

The metabolic activation of some polycyclic hydrocarbons: the role of dihydrodiols and diol-epoxides.

P. Sims, 1981, Advances in experimental medicine and biology.

The Involvement of Bay-Region and Non-Bay-Region Diol-epoxides in the in Vivo Binding of Benz(a)anthrocene Derivatives to DNA

P. Vigny, C. S. Cooper, P. Grover, 1981 .

Additional evidence for the involvement of the 3,4-diol 1,2-oxides in the metabolic activation of 7,12-dimethylbenz[a]anthracene in mouse skin.

C. Walsh, A. Hewer, C. S. Cooper, 1980, Chemico-biological interactions.

Metabolic activation of polycyclic hydrocarbons Fluorescence spectral evidence is consistent with metabolism at the 1,2‐ and 3,4‐double bonds of 7‐methylbenz[a]anthracene

P. Vigny, P. Grover, H. Coulomb, 1977, FEBS letters.

In vitro malignant transformation of mouse fibroblasts by non-K-region dihydrodiols derived from 7-methylbenz(a)anthracene, 7,12-dimethylbenz(a)anthracene, and benzo(a)pyrene.

H. Marquardt, P. Grover, P. Sims, 1976, Cancer research.

The conversion of benzo[a]pyrene 4,5-oxide into 4-hydroxybenzo[a]pyrene in the presence of polyriboguanylic acid

A. W. Murray, P. Grover, P. Sims, 1976 .

Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of BHK 21 cells.

J. Forrester, P. Grover, P. Sims, 1971, Biochemical pharmacology.

K-region epoxides of polycyclic hydrocarbons: reactions with nucleic acids and polyribonucleotides.

P. Grover, P. Sims, 1973, Biochemical pharmacology.

Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons.

C. Heidelberger, J. Selkirk, T. Kuroki, 1972, Cancer research.

The carcinogenic activities in mice of compounds related to 3‐methylcholanthrene

P. Sims, C. Beatty, 1967, International journal of cancer.

The activities of some polycyclic hydrocarbons and their "K region" epoxides in an in vitro-in vivo carcinogenicity test system.

P. Sims, A. Flaks, 1975, British Journal of Cancer.

Polycyclic hydrocarbon activation and metabolism in epithelial cell aggregates prepared from human mammary tissue

A. Neville, P. Sims, P. Grover, 1980, International journal of cancer.

The metabolic activation of chemical carcinogens.

P. Sims, 1980, British medical bulletin.

Metabolic activation of benz[a]anthracene in hamster embryo cells: the structure of a guanosine-anti-BA-8,9-diol 10,11-oxide adduct.

P. Cary, C. S. Cooper, P. Grover, 1980, Carcinogenesis.

Fluorescence spectral evidence that benzo[a]pyrene is activated by metabolism in mouse skin to a diol-epoxide and a phenol-epoxide.

P. Vigny, Y. Ginot, C. S. Cooper, 1980, Carcinogenesis.

The induction of sister-chromatid exchanges in Chinese hamster ovary cells by some epoxides and phenolic derivatives of benzo[a]pyrene.

P. Grover, P. Sims, K. Pal, 1980, Mutation research.

Some properties of "K-region" epoxides of polycyclic aromatic hydrocarbons.

P. Grover, P. Sims, A. Swaisland, 1973, Biochemical pharmacology.

Metabolism of polycyclic hydrocarbons by rat-lung preparations.

A. Hewer, P. Grover, P. Sims, 1974, Biochemical pharmacology.

The metabolism and activation of polycyclic aromatic hydrocarbons in epithelial cell aggregates and fibroblasts prepared from rat mammary tissue.

A. Hewer, C. S. Cooper, P. Grover, 1982, Carcinogenesis.

Inactivation of a diol epoxide by dihydrodiol dehydrogenase but not by two epoxide hydrolases.

H. Glatt, F. Oesch, C. S. Cooper, 1982, Science.

Large differences in metabolic activation and inactivation of chemically closely related compounds: effects of pure enzymes and enzyme induction on the mutagenicity of the twelve monomethylated benz[a]anthracenes, 7,12-dimethylbenz[a]anthracene and benz[a]anthracene in the Ames test.

H. Glatt, F. Oesch, P. Bentley, 1981, Carcinogenesis.

The metabolism of benz(a)anthracene and dibenz(a,h)anthracene and their related "K-region" epoxides, cis-dihydrodiols and phenols by hamster embryo cells.

C. Heidelberger, J. Selkirk, T. Kuroki, 1973, Biochemical pharmacology.

The metabolism of some aromatic hydrocarbons by mouse embryo cell cultures.

P. Sims, 1970, Biochemical pharmacology.

Metabolism of polycyclic compounds. 18. The secretion of metabolites of naphthalene, 1:2-dihydronaphthalene and 1:2-epoxy-1:2:3:4-tetrahydronaphthalene in rat bile.

E. Boyland, P. Sims, G. Ramsay, 1961, The Biochemical journal.

Metabolism of polycyclic compounds. 16. The metabolism of 1:2-dihydronaphthalene and 1:2-epoxy-1:2:3:4-tetrahydronaphthalene.

E. Boyland, P. Sims, 1960, The Biochemical journal.

Metabolism of polycyclic compounds. 12. An acid-labile precursor of 1-naphthylmercapturic acid and naphthol: an N-acetyl-S-(1:2-dihydrohydroxy-naphthyl)-L-cysteine.

E. Boyland, P. Sims, 1958, The Biochemical journal.

The metabolism of benzo(a)pyrene by Chinese hamster ovary cells in culture.

P. Grover, P. Sims, K. Pal, 1980, Xenobiotica; the fate of foreign compounds in biological systems.

9. The oxidation of aromatic amines. Part VI. Persulphate oxidation of some carcinogenic aromatic amines

P. Sims, 1958 .

Preferential binding of polycyclic hydrocarbons to matrix-bound DNA in rat-liver nuclei.

P. Grover, P. Sims, N. Mironov, 1983, Carcinogenesis.

CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES.

P. Grover, P. Sims, 1965, The Biochemical journal.

Variations dependent on Age and Diet in the Metabolism of 7,12-Dimethylbenz[a]-anthracene by Rat Liver Homogenates

P. Grover, P. Sims, 1967, Nature.

The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice.

F. Roe, P. Grover, P. Sims, 1975, British Journal of Cancer.

Metabolism of polycyclic compounds. 22. The metabolism of trans-9,10-dihydro-9,10-dihydroxyphenanthrene in rats.

E. Boyland, P. Sims, 1962, The Biochemical journal.

The formation of an epoxide in the microsomal metabolism of 7,12-dimethylbenz(a)anthracene.

A. Hewer, P. Sims, J. Booth, 1972, The Biochemical journal.

The metabolism of γ-2,3,4,5,6-pentachlorocyclohex-1-ene and γ-hexachlorocyclohexane in rats

P. Sims, P. Grover, 1965 .

The metabolism of polycyclic hydrocarbons by cultured human lymphocytes

J. Booth, P. Sims, K. Pal, 1974, FEBS letters.

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.

P. Sims, 1973, The Biochemical journal.

Mutagenicity of 'K-region' epoxides of polycyclic hydrocarbons towards bacteriophage T2.

P. Grover, P. Sims, M. Cookson, 1971, The Biochemical journal.

Enzymic reduction of aromatic hydrocarbon epoxides by the microsomal fraction of rat liver.

A. Hewer, P. Sims, J. Booth, 1975, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of Polycyclic Compounds

Che, P. Sims, 2005 .

METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 1,4-EPOXY-1,4-DIHYDRONAPHTHALENE IN RATS.

P. Sims, 1965, Biochemical Journal.

The metabolism of dibenzo(a, h)pyrene and dibenzo(a, i)pyrene and related compounds by liver preparations and their enzyme-induced binding to cellular macromolecules.

P. Sims, J. F. Waterfall, 1973, Biochemical pharmacology.

The conversion of phenanthrene 9,10-oxide and dibenz[a,h]anthracene 5,6-oxide into dihydrodiols by a rat-liver microsomal enzyme.

H. Pandov, P. Sims, 1970, Biochemical pharmacology.

The metabolic activation of 7-methylbenz(a)anthracene in mouse skin: High tumour-initiating activity of the 3,4-dihydrodiol

P. Grover, I. Chouroulinkov, P. Sims, 1977 .

Metabolism of polycyclic compounds. 21. The metabolism of phenanthrene in rabbits and rats: dihydrodihydroxy compounds and related glucosiduronic acids.

E. Boyland, P. Sims, 1962, The Biochemical journal.

Metabolism of polycyclic compounds. 14. The conversion of naphthalene into compounds related to trans-1:2-dihydro-1:2-dihydroxynaphthalene by rabbits.

P. Sims, 1959, The Biochemical journal.

The involvement of a non-'bay-region' diol-epoxide in the formation of benz(a)anthracene-DNA adducts in a rat-liver microsomal system.

C. Walsh, A. Hewer, P. Gervasi, 1979, Biochemical and biophysical research communications.

Biological activities of dihydrodiols derived from two polycyclic hydrocarbons in rodent test systems.

P. Grover, I. Chouroulinkov, P. Sims, 1979, British Journal of Cancer.

The preparation of dihydrodiols from 7-methylbenz[a]-anthracene.

C. Walsh, A. Hewer, P. Grover, 1978, Chemico-biological interactions.

Fluorescence spectra of nucleoside-hydrocarbon adducts formed in mouse skin treated with 7,12-dimethylbenz[a]anthracene.

P. Vigny, C. S. Cooper, P. Grover, 1981, Carcinogenesis.

Polycyclic Hydrocarbon Epoxides as Active Metabolic Intermediates

P. Sims, 1977 .

The formation of dihydrodiols in the chemical or enzymic oxidation of dibenz[a,c]anthracene, dibenz[a,h]-anthracene and chrysene.

A. MacNicoll, P. Grover, P. Sims, 1979, Chemico-biological interactions.

The metabolic activation of chrysene

P. Grover, P. Sims, R. Hodgson, 1983 .

Metabolic activation of 7,12-dimethylbenz[a]anthracene in rat mammary tissue: fluorescence spectral characteristics of hydrocarbon-DNA adducts.

D. Phillips, A. Hewer, P. Vigny, 1985, Cancer letters.

The enzyme‐catalysed conversion of a non‐‘bay‐region’ diol‐epoxide of benz[a] anthracene into a glutathione conjugate

A. Hewer, C. S. Cooper, P. Sims, 1980, FEBS letters.

The association of bacterial mutagenicity of hydrocarbon-derived 'bay-region' dihydrodiols with the Iball indices for carcinogenicity and with the extents of DNA-binding on mouse skin of the parent hydrocarbons.

H. Bartsch, C. Malaveille, P. Grover, 1979, Chemico-biological interactions.

The formation of dihydrodiols from benzo[alpha]pyrene by oxidation with an ascorbic acid/ferrous sulphate/EDTA system.

C. Walsh, A. Hewer, P. Grover, 1979, Chemico-biological interactions.

Different pathways involved in the metabolism of the 7,8- and 9,10-dohydrodiols of benzo(a)pyrene.

P. Sims, J. Booth, 1976, Biochemical pharmacology.

Metabolism of polycyclic compounds. 19. The metabolism of phenanthrene in rabbits and rats: phenols and sulphuric esters.

P. Sims, 1962, The Biochemical journal.

The metabolism of carcinogenic polycyclic hydrocarbons by tissues of the respiratory tract.

K. Pal, P. Grover, P. Sims, 1975, Biochemical Society transactions.

Metabolism of polycyclic compounds. 15. The conversion of naphthalene into a derivative of glutathione by rat-liver slices.

E. Boyland, P. Sims, J. Booth, 1960, The Biochemical journal.

Metabolic activation of chrysene by hamster embryo cells: evidence for the formation of a 'bay-region' diol-epoxide-N2-guanine adduct in RNA.

P. Cary, P. Grover, P. Sims, 1983, Carcinogenesis.

The metabolic activation of chrysene by hamster embryo cells.

P. Grover, P. Sims, R. Hodgson, 1982, Carcinogenesis.

Reactions of 'bay-region' and non-'bay-region' diol-epoxides of benz(a)anthracene with DNA: evidence indicating that the major products are hydrocarbon-N2-guanine adducts.

K. Hemminki, C. S. Cooper, P. Grover, 1980, Carcinogenesis.

Formation of the 11,12-diol as a metabolite of benzo(a)pyrene by rat skin in vivo.

A. Weston, P. Grover, P. Sims, 1982, Biochemical and biophysical research communications.

Metabolism of polycyclic compounds. 25. The metabolism of anthracene and some related compounds in rats.

P. Sims, 1964, The Biochemical journal.

4'-Hydroxylation of biphenyl by yeast containing cytochrome P-450: radiation and thermal stability, comparisons with liver enzyme (oxidized and reduced forms).

A. Wiseman, J. A. Gondal, P. Sims, 1975, Biochemical Society transactions.

Epoxides derived from various polycyclic hydrocarbons as substrates of homogeneous and microsome-bound epoxide hydratase. A general assay and kinetic properties.

F. Oesch, P. Bentley, P. Sims, 1976, European journal of biochemistry.

Inactivation of a diol-epoxide and a K-region epoxide with high efficiency by glutathione transferase X.

H. Glatt, F. Oesch, T. Friedberg, 1983, Cancer research.

The synthesis of 8- and 9-hydroxybenzo[a]pyrene and the role of the products in benzo[a]pyrene metabolism.

P. Sims, 1968, Journal of the Chemical Society. Perkin transactions 1.

Metabolism of polycylic compounds. XI. The conversion of naphthalene into 2-hydroxy-1-naphthyl sulphate in the rabbit.

E. Boyland, P. Sims, 1957, The Biochemical journal.

Mutagenicity of benzo[a]pyrene 7,8-dihydrodiol and 7,12-dimethylbenz[a]anthracene 3,4-dihydrodiol in S. typhimurium mediated by microsomes from rat liver and mouse skin.

H. Bartsch, W. Pyerin, C. Malaveille, 1980, Chemico-biological interactions.

Comparison of the products of the reaction of 7-methylbenz(a)anthracene 5,6-oxide and RNA, with those formed in 7-methylbenz(a)anthracene-treated cells.

W. Baird, P. Grover, P. Sims, 1976, Cancer research.

Malignant transformation in vitro of mouse fibroblasts by 7, 12‐dimethylbenz(A)anthracene and 7‐hydroxymethylbenz(A)anthracene and by their K‐region derivatives

H. Marquardt, P. Grover, P. Sims, 1974, International journal of cancer.