Brian I. Knapp

发表

In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder

D. Deaver, J. Bidlack, D. Arnelle, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Mixed Mu/Kappa Opioid Agonists

J. Bidlack, Brian I. Knapp, 2013 .

Design and Synthesis of Novel Dimeric Morphinan Ligands for κ and μ Opioid Receptors

N. Mello, A. Zhang, J. Neumeyer, 2003 .

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

S. Salvadori, G. Balboni, J. Neumeyer, 2006, Journal of medicinal chemistry.

Can Amphipathic Helices Influence the CNS Antinociceptive Activity of Glycopeptides Related to β-Endorphin?

J. Bidlack, Yingxue Li, E. Bilsky, 2014, Journal of medicinal chemistry.

Glycosylation Improves the Central Effects of DAMGO

J. Bidlack, F. Porreca, P. Davis, 2007, Chemical biology & drug design.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.

J. Alvarez, J. Bidlack, M. Wentland, 2013, Bioorganic & medicinal chemistry letters.

Structural Requirements for CNS Active Opioid Glycopeptides.

J. Bidlack, Yingxue Li, E. Bilsky, 2015, Journal of medicinal chemistry.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, J. Neumeyer, 2011, European journal of medicinal chemistry.

Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

S. Salvadori, G. Balboni, J. Neumeyer, 2010 .

Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands.

M. Decker, J. Neumeyer, J. Bidlack, 2009, Journal of medicinal chemistry.

Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone.

J. Bidlack, M. Wentland, Qun Lu, 2005, Bioorganic & medicinal chemistry letters.

Pharmacological Properties of Bivalent Ligands Containing Butorphan Linked to Nalbuphine, Naltrexone, and Naloxone at μ, δ, and κ Opioid Receptors

J. Neumeyer, J. Bidlack, Xuemei Peng, 2007 .

Phosphorylation of Enkephalins: NMR and CD Studies in Aqueous and Membrane‐Mimicking Environments

L. Abrell, J. Bidlack, E. Bilsky, 2011, Chemical biology & drug design.

Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans--further SAR of levorphanol.

J. Neumeyer, J. Bidlack, Qizheng Yao, 2007, Journal of medicinal chemistry.

Aminothiazolomorphinans with mixed κ and μ opioid activity.

Thomas Scrimale, J. Neumeyer, J. Bidlack, 2011, Journal of medicinal chemistry.

In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors.

J. Neumeyer, J. Bidlack, Xuemei Peng, 2007, Bioorganic & medicinal chemistry.

Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors.

J. Neumeyer, J. Bidlack, Bin Zhang, 2012, Journal of medicinal chemistry.

10-Ketomorphinan and 3-Substituted-3-desoxymorphinan Analogues as Mixed κ and μ Opioid Ligands: Synthesis and Biological Evaluation of Their Binding Affinity at Opioid Receptors

A. Zhang, J. Neumeyer, J. Bidlack, 2004 .

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic

O. Zuiderveld, R. Leurs, J. Bidlack, 2011, PAIN®.

Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence

J. Bidlack, Brian I. Knapp, Sophia I Eliseeva, 2021, Neuropharmacology.

Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.

J. Neumeyer, J. Bidlack, Xuemei Peng, 2007, Journal of medicinal chemistry.

Unique Pharmacological Properties of the Kappa Opioid Receptor Signaling Through Gαz as Shown with Bioluminescence Resonance Energy Transfer

J. Bidlack, Brian I. Knapp, M. Barnett, 2020, Molecular Pharmacology.

Opioids Activate Brain Analgesic Circuits Through Cytochrome P450/Epoxygenase Signaling

O. Zuiderveld, R. Leurs, J. Mazurkiewicz, 2010, Nature Neuroscience.

Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.

M. Decker, J. Neumeyer, J. Bidlack, 2010, Journal of medicinal chemistry.

Preliminary pharmacological evaluation of enantiomeric morphinans.

J. Neumeyer, J. Bidlack, E. Chartoff, 2014, ACS chemical neuroscience.

High-affinity carbamate analogues of morphinan at opioid receptors.

J. Neumeyer, J. Bidlack, Xuemei Peng, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and pharmacological evaluation of aminothiazolomorphinans at the mu and kappa opioid receptors.

J. Neumeyer, J. Bidlack, E. Chartoff, 2013, Journal of medicinal chemistry.

Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at μ, δ, and κ opioid receptors

J. Neumeyer, J. Bidlack, Xuemei Peng, 2006 .

Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors.

J. Neumeyer, J. Bidlack, Brian I. Knapp, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors.

N. Mello, A. Zhang, J. Neumeyer, 2003, Journal of medicinal chemistry.

Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-α-induced depression model

S. O’Mara, D. Deaver, J. Bidlack, 2018, Brain, Behavior, and Immunity.

Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors.

J. Neumeyer, J. Bidlack, Xuemei Peng, 2006, Journal of medicinal chemistry.

10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.

A. Zhang, J. Neumeyer, J. Bidlack, 2004, Journal of medicinal chemistry.

Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-α-induced depression model

S. O’Mara, D. Deaver, J. Bidlack, 2018, Brain, Behavior, and Immunity.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, J. Neumeyer, 2011, European journal of medicinal chemistry.