K. Kawai

发表

Characteristics of TRK-130 (Naltalimide), a Novel Opioid Ligand, as a New Therapeutic Agent for Overactive Bladder

N. Yoshimura, S. Yoshikawa, M. Fujimura, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of the First in Class Drug for Intractable Itch, Nalfurafine Hydrochloride

H. Nagase, K. Kawai, K. Kawamura, 2011 .

Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.

H. Nagase, Y. Imamura, T. Miyamoto, 2008, Bioorganic & medicinal chemistry.

Rational drug design and synthesis of a selective opioid receptor antagonist on the basis of the accessory site concept.

M. Narita, H. Nagase, H. Mizoguchi, 2004, Bioorganic & medicinal chemistry letters.

Possible Pharmacotherapy of the Opioid κ Receptor Agonist for Drug Dependence

M. Narita, Tsutomu Suzuki, H. Nagase, 2004 .

Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan.

H. Nagase, K. Kawai, K. Kawamura, 1998, Chemical & pharmaceutical bulletin.

Pharmacological profile of TAN‐452, a novel peripherally acting opioid receptor antagonist for the treatment of opioid‐induced bowel syndromes

Tsutomu Suzuki, Y. Ishihara, K. Kawai, 2018, Life sciences.

Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.

R. Tanimura, Yuji Sugawara, K. Kawai, 2017, Bioorganic & medicinal chemistry letters.

Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.

S. Okazaki, Shuji Udagawa, Takumi Aoki, 2013, Bioorganic & medicinal chemistry letters.

Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.

J. Kamei, S. Ueno, H. Nagase, 2008, Journal of medicinal chemistry.

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

H. Ohno, S. Ueno, H. Nagase, 2008, Bioorganic & Medicinal Chemistry.

Enantioselective addition of diorganozincs to aldehydes catalyzed by β-amino alcohols

Ryoji Noyori, Seiji Suga, Masahiko Hayashi, 1990 .

Enantioselective alkylation of carbonyl compounds. From stoichiometric to catalytic asymmetric induction

R. Noyori, M. Kitamura, K. Kawai, 1988 .

Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex

T. Doi, N. Yoshimura, S. Yoshikawa, 2017, International Urology and Nephrology.

Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.

J. Kamei, H. Nagase, A. Saitoh, 2004, Journal of pharmacological sciences.

A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice

J. Hayashi, K. Nakada, M. Kainoh, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Rational Drug Design and Synthesis of a Highly Selective Nonpeptide δ‐Opioid Agonist, (4aS*,12aR*)‐4a‐ (3‐Hydroxyphenyl)‐2‐methyl‐1,2,3,4,4a,5,12,12a‐octahydropyrido [3,4‐b]acridine (TAN‐67).

H. Nagase, T. Endoh, K. Kawai, 1999 .

Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67).

H. Nagase, T. Endoh, K. Kawai, 1998, Chemical & pharmaceutical bulletin.

Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor.

M. Narita, H. Nagase, H. Mizoguchi, 2004, Bioorganic & medicinal chemistry.

Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties.

H. Nagase, T. Endoh, H. Fujii, 2001, Drug design and discovery.

Release of [Met5]enkephalin from the spinal cord by intraventricularly administered endomorphin-2, but not endomorphin-1 in the anesthetized rat

M. Ohsawa, M. Narita, H. Nagase, 2001, Neuroscience Letters.

Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence.

M. Narita, Tsutomu Suzuki, H. Nagase, 2004, Annals of the New York Academy of Sciences.

HIS-388, a Novel Orally Active and Long-Acting 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Ameliorates Insulin Sensitivity and Glucose Intolerance in Diet-Induced Obesity and Nongenetic Type 2 Diabetic Murine Models

S. Okazaki, Takehiro Takahashi, K. Kawai, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Catalytic asymmetric induction. Highly enantioselective addition of dialkylzincs to aldehydes.

R. Noyori, M. Kitamura, K. Kawai, 1986, Journal of the American Chemical Society.

Discovery of a Structurally Novel Opioid ϰ-Agonist Derived from 4,5-Epoxymorphinan.

H. Nagase, K. Kawai, K. Kawamura, 1998 .

S. Okazaki, M. Kainoh, Takehiro Takahashi, 2014, The Journal of Pharmacology and Experimental Therapeutics.

A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice

J. Hayashi, K. Nakada, M. Kainoh, 2015, The Journal of Pharmacology and Experimental Therapeutics.