N. Lawrence

发表

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.

C. Harris, K. Chibale, D. Warner, 2015, Bioorganic & medicinal chemistry.

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.

T. Myers, C. Eyermann, K. Chibale, 2021, Journal of medicinal chemistry.

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

K. Chibale, Dale Taylor, T. Ioerger, 2020, ACS infectious diseases.

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

G. Drewes, C. Harris, Markus Boesche, 2017, Journal of medicinal chemistry.

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

Paul W Smith, K. Chibale, Dale Taylor, 2015, Journal of medicinal chemistry.

Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.

K. Chibale, Dale Taylor, M. Witty, 2015, Journal of medicinal chemistry.

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment

C. Eyermann, K. Chibale, Dale Taylor, 2020, ACS omega.

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.

E. Winzeler, S. Meister, K. Chibale, 2016, Journal of medicinal chemistry.

Volatile metabolic profiling of SA Chenin blanc fresh and fruity and rich and ripe wine styles : development of analytical methods for flavour compounds (aroma and flavour) and application of chemometrics for resolution of complex analytical measurements

N. Lawrence, 2012 .

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

M. Bogyo, D. Fidock, M. Vanaerschot, 2018, Journal of the American Chemical Society.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.

K. Chibale, Dale Taylor, K. Wicht, 2018, Journal of medicinal chemistry.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

R. Price, K. Chibale, Dale Taylor, 2018, Antimicrobial Agents and Chemotherapy.

Quantification of glutathione, catechin and caffeic acid in grape juice and wine by a novel ultra-performance liquid chromatography method

D. Fracassetti, A. Tirelli, A. Tredoux, 2011 .

New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase.

S. Fienberg, K. Chibale, Dale Taylor, 2020, ACS infectious diseases.

Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.

Paul W Smith, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.

T. Myers, C. Eyermann, K. Chibale, 2021, Journal of medicinal chemistry.

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

K. Chibale, T. Egan, Dale Taylor, 2020, Journal of medicinal chemistry.

Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.

K. Chibale, T. Egan, Dale Taylor, 2022, Journal of medicinal chemistry.

Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model

L. Wiesner, N. Dambuza, Liezl Gibhard, 2015, Malaria Journal.

Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies.

K. Chibale, G. Dziwornu, L. Birkholtz, 2021, Journal of medicinal chemistry.

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.

K. Chibale, T. Egan, Dale Taylor, 2018, ACS infectious diseases.

Investigation into the Structures and Properties of Multicomponent Crystals Formed from a Series of 7-Chloroquinolines and Aromatic Acids

C. de Kock, N. Lawrence, M. Blackie, 2019, Crystal Growth & Design.

Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

K. Chibale, Dale Taylor, G. Basarab, 2018, Antimicrobial Agents and Chemotherapy.

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin

K. Chibale, L. Wiesner, J. Louw, 2017, Molecules.

In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102

L. Wiesner, Liezl Gibhard, Peter Smith, 2016, Antimicrobial Agents and Chemotherapy.

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.

C. Harris, K. Chibale, D. Warner, 2015, Bioorganic & medicinal chemistry.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

E. Winzeler, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

M. Bogyo, D. Fidock, M. Vanaerschot, 2018, Journal of the American Chemical Society.

Antiplasmodial imidazopyridazines: structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG profiles.

K. Chibale, Dale Taylor, S. Wittlin, 2018, MedChemComm.