A. Cozzi

发表

The role of the L-chain in ferritin iron incorporation. Studies of homo and heteropolymers.

A. Albertini, P. Arosio, S. Levi, 1994, Journal of molecular biology.

Massive iron accumulation in PKAN-derived neurons and astrocytes: light on the human pathological phenotype

V. Tiranti, S. Taverna, I. Di Meo, 2022, Cell death & disease.

Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties.

B. Garavaglia, E. Rovelli, S. Levi, 2012, Human molecular genetics.

Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and of two H-chain deletion mutants.

G. Cesareni, P. Arosio, A. Luzzago, 1988, The Journal of biological chemistry.

Iron detoxifying activity of ferritin

P. Arosio, S. Levi, P. Santambrogio, 1990, FEBS letters.

PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation

V. Tiranti, I. Di Meo, S. Levi, 2022, Frontiers in Cellular Neuroscience.

Evidence of H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin.

P. Harrison, P. Arosio, S. Yewdall, 1992, The Biochemical journal.

Antiferritin single-chain Fv fragment is a functional protein with properties of a partially structured state: comparison with the completely folded V(L) domain.

Y. Tsybovsky, A. Chumanevich, A. Dubnovitsky, 2000, Biochemistry.

H ferritin silencing induces protein misfolding in K562 cells: A Raman analysis.

G. Cuda, B. Quaresima, F. Costanzo, 2015, Free radical biology & medicine.

Role of iron and ferritin in TNFα‐induced apoptosis in HeLa cells

P. Arosio, S. Levi, P. Santambrogio, 2003 .

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome

M. Muckenthaler, V. Broccoli, B. Garavaglia, 2013, The Journal of experimental medicine.

Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation

L. Cremonesi, A. Gallì, M. D. Della Porta, 2011, Haematologica.

Role of iron and ferritin in TNFalpha-induced apoptosis in HeLa cells.

P. Arosio, S. Levi, P. Santambrogio, 2003, FEBS letters.

Evidence that the specificity of iron incorporation into homopolymers of human ferritin L- and H-chains is conferred by the nucleation and ferroxidase centres.

P. Arosio, S. Levi, P. Santambrogio, 1996, The Biochemical journal.

Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia.

F. Taroni, E. Rovelli, S. Levi, 2008, Human molecular genetics.

Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.

T. Ganz, D. Melisi, S. Mueller, 2018, Antioxidants & redox signaling.

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

M. Ferrari, S. Taverna, V. Broccoli, 2019, Stem cell reports.

Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms

D. Girelli, M. Ferrari, I. Fermo, 2004, Journal of Medical Genetics.

Human serum ferritin G‐peptide is recognized by anti‐L ferritin subunit antibodies and concanavalin‐A

P. Arosio, S. Levi, P. Santambrogio, 1987, British journal of haematology.

Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation

L. Cremonesi, M. Porta, A. Gallì, 2011, Haematologica.

Pathogenic mechanism and modeling of neuroferritinopathy

S. Levi, E. Rovida, P. Santambrogio, 2021, Cellular and Molecular Life Sciences.

Iron Pathophysiology in Neurodegeneration with Brain Iron Accumulation.

S. Levi, P. Santambrogio, A. Cozzi, 2019, Advances in experimental medicine and biology.

Transient overexpression of human H- and L-ferritin chains in COS cells.

C. Beaumont, F. Perrone, M. Bourgeois, 1998, The Biochemical journal.

Mechanisms of regulation of ferritin synthesis in rat liver during experimental inflammation.

P. Arosio, L. Schiaffonati, G. Cairo, 1988, Experimental and molecular pathology.

Pathogenic mechanism and modeling of neuroferritinopathy

S. Levi, E. Rovida, P. Santambrogio, 2021, Cellular and Molecular Life Sciences.

Erythema Multiforme Major following SARS‐CoV‐2 vaccine

G. Felisati, C. Pipolo, A. Saibene, 2021, Clinical case reports.

Effects of modifications near the 2-, 3- and 4-fold symmetry axes on human ferritin renaturation.

P. Artymiuk, P. Harrison, P. Arosio, 1997, The Biochemical journal.

Interaction of hemoglobin E and several forms of alpha-thalassemia in Cambodian families.

J. Garcia-conde, A. Schmitt-Graeff, R. Paroni, 2003, Haematologica.

Development of an immunoassay for all human isoferritins, and its application to serum ferritin evaluation.

G. Ruggeri, P. Arosio, S. Levi, 1989, Clinica chimica acta; international journal of clinical chemistry.

Iron up-modulates the expression of transferrin receptors during monocyte-macrophage maturation.

U. Testa, M. Sargiacomo, M. T. Quaranta, 1989, The Journal of biological chemistry.

Identification of the EPR-active iron-nitrosyl complexes in mammalian ferritins.

P. Arosio, N. Chasteen, M. Lee, 1994, Biochemistry.

Expression and structural and functional properties of human ferritin L-chain from Escherichia coli.

P. Arosio, S. Levi, J. Salfeld, 1989, Biochemistry.

Functional and immunological analysis of recombinant mouse H- and L-ferritins from Escherichia coli.

F. Magni, P. Arosio, S. Levi, 2000, Protein expression and purification.

Evidence that residues exposed on the three-fold channels have active roles in the mechanism of ferritin iron incorporation.

P. Arosio, S. Levi, P. Santambrogio, 1996, The Biochemical journal.

Mechanisms of Ferritin Iron Incorporation: A Study with Recombinant and Mutant Human Ferritins

G. Cesareni, P. Arosio, A. Luzzago, 1991 .

Production and characterization of recombinant heteropolymers of human ferritin H and L chains.

P. Arosio, S. Levi, A. Albertini, 1993, The Journal of biological chemistry.

Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model

V. Tiranti, D. Brunetti, G. d’Amati, 2012, Human molecular genetics.

Characteristics and expression of binding sites specific for ferritin H- chain on human cell lines

P. Arosio, S. Fargion, A. Fracanzani, 1988 .

Overexpression of Wild Type and Mutated Human Ferritin H-chain in HeLa Cells

A. Albertini, P. Arosio, S. Levi, 2000, The Journal of Biological Chemistry.

Chemico-physical and functional differences between H and L chains of human ferritin.

P. Arosio, S. Levi, A. Albertini, 1994, Advances in Experimental Medicine and Biology.

Characterization of nuclear ferritin and mechanism of translocation.

J. Connor, M. Fried, S. Patton, 2005, The Biochemical journal.

A mutational analysis of the epitopes of recombinant human H-ferritin.

G. Ruggeri, P. Arosio, A. Luzzago, 1990, Biochimica et biophysica acta.

Human Mitochondrial Ferritin Expressed in HeLa Cells Incorporates Iron and Affects Cellular Iron Metabolism*

P. Arosio, S. Levi, A. Albertini, 2002, The Journal of Biological Chemistry.

Characterization of the l-ferritin variant 460InsA responsible of a hereditary ferritinopathy disorder

P. Arosio, S. Levi, P. Santambrogio, 2006, Neurobiology of Disease.

Mutant Ferritin L-chains That Cause Neurodegeneration Act in a Dominant-negative Manner to Reduce Ferritin Iron Incorporation*

B. Gallois, Sara Luscieti, P. Arosio, 2010, The Journal of Biological Chemistry.

Characteristics of a ferritin‐binding protein present in human serum

M. Cazzola, P. Arosio, S. Levi, 1987, British journal of haematology.

Cellular iron status influences the functional relationship between microglia and oligodendrocytes

Xuesheng Zhang, A. Cozzi, B. Slagle‐Webb, 2006, Glia.

L-ferritin transfection with siRNAs and cDNAs: evidence for a proliferative role of Analysis of the biologic functions of H- and L-ferritins in HeLa cells by

P. Arosio, S. Levi, P. Santambrogio, 2010 .

Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin.

P. Arosio, S. Levi, P. Santambrogio, 2004, Blood.

Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron‐deficient phenotype

A. Corti, A. Albertini, P. Arosio, 1999, FEBS letters.

Massive iron accumulation in PKAN-derived neurons and astrocytes: light on the human pathological phenotype

V. Tiranti, S. Taverna, I. Di Meo, 2022, Cell Death & Disease.

Mitochondrial Ferritin: Its Role in Physiological and Pathological Conditions

S. Levi, P. Santambrogio, M. Ripamonti, 2021, Cells.

Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy

Mario Amendola, P. Arosio, E. Rovelli, 2010, Neurobiology of Disease.

The expression of human mitochondrial ferritin rescues respiratory function in frataxin-deficient yeast.

Heather A. O'Neill, P. Arosio, S. Levi, 2004, Human molecular genetics.

Construction of a ferroxidase center in human ferritin L-chain.

P. Arosio, S. Levi, A. Albertini, 1994, The Journal of biological chemistry.

PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes

V. Tiranti, P. Pizcueta, M. Martinell, 2023, Pharmaceutics.

Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation.

P. Arosio, S. Levi, A. Cozzi, 2005, Best practice & research. Clinical haematology.

A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits

M. Giorgio, F. Codazzi, F. Cirulli, 2015, Neurobiology of Disease.

Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration

V. Tiranti, M. Ferrari, S. Taverna, 2016, EMBO molecular medicine.

Harmful Iron-Calcium Relationship in Pantothenate kinase Associated Neurodegeneration

V. Tiranti, L. Chiapparini, S. Taverna, 2020, International journal of molecular sciences.

Characteristics and expression of binding sites specific for ferritin H-chain on human cell lines.

P. Arosio, S. Fargion, A. Fracanzani, 1988, Blood.

Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model

V. Tiranti, D. Brunetti, G. d’Amati, 2012 .

Structural and functional studies of human ferritin H and L chains.

G. Cesareni, P. Arosio, A. Luzzago, 1991, Current studies in hematology and blood transfusion.

Identification of two novel mutations in the 5'-untranslated region of H-ferritin using denaturing high performance liquid chromatography scanning.

M. Ferrari, R. Paroni, I. Fermo, 2003, Haematologica.

Iron imbalance in neurodegeneration

M. Ripamonti, A. Cozzi, A. Moro, 2024, Molecular psychiatry.

L-ferritin transfection with siRNAs and cDNAs: evidence for a proliferative role of Analysis of the biologic functions of H- and L-ferritins in HeLa cells by

P. Arosio, S. Levi, P. Santambrogio, 2010 .

Case report: a subject with a mutation in the ATG start codon of L-ferritin has no haematological or neurological symptoms

D. Girelli, M. Ferrari, I. Fermo, 2004, Journal of Medical Genetics.