A. Blaser

发表

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.

W. Denny, W. Wilson, H. Lee, 2008, Journal of medicinal chemistry.

5-Substituted 2-Aminopyridine C-Nucleosides as Protonated Cytidine Equivalents: Increasing Efficiency and Selectivity in DNA Triple-Helix Formation

C. Leumann, S. Hildbrand, S. Parel, 1997 .

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

Christopher B. Cooper, W. Denny, B. Palmer, 2017, ACS medicinal chemistry letters.

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

W. Denny, B. Palmer, S. Franzblau, 2019, Bioorganic & medicinal chemistry.

Development of (6R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis

Christopher B. Cooper, V. Yardley, W. Denny, 2018, Journal of medicinal chemistry.

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876—A Less Toxic and More Potent Analogue of Bedaquiline

W. Denny, B. Palmer, C. Cooper, 2020, Molecules.

Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

W. Denny, A. M. Thompson, B. Palmer, 2010 .

The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.

W. Denny, S. Hagen, J. Smaill, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains.

W. Denny, A. M. Thompson, B. Palmer, 2010, Journal of medicinal chemistry.

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.

J. A. Spicer, P. Ellis, W. Denny, 2016, Journal of medicinal chemistry.

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.

V. Yardley, W. Denny, A. M. Thompson, 2016, Journal of medicinal chemistry.

Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

W. Denny, A. M. Thompson, B. Palmer, 2010, Journal of medicinal chemistry.

Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

W. Denny, A. M. Thompson, B. Palmer, 2009, Journal of medicinal chemistry.

Stereoselective inhibition of alpha-L-fucosidases by N-benzyl aminocyclopentitols.

J. Reymond, A. Blaser, 2000, Organic Letters.

Stereoselective Inhibition of α-L-Fucosidases by N-Benzyl Aminocyclopentitols.

J. Reymond, A. Blaser, 2000 .

A Selectiveα-L-Fucosidase Inhibitor Based on an Aminocyclopentane Framework

J. Reymond, A. Blaser, 1999 .

Synthesis , Reduction Potentials , and Antitubercular Activity of Ring A / B Analogues of the Bioreductive Drug ( 6 S )-2-Nitro

W. Denny, A. M. Thompson, B. Palmer, 2008 .

Development of ( 6 R ) ‐ 2-Nitro-6-[ 4-( tri fl uoromethoxy )

Christopher B. Cooper, V. Yardley, W. Denny, 2018 .

(1SR,2SR,4SR)-7-Oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid

J. Reymond, H. Bürgi, J. Hauser, 2004 .

Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy.

W. Denny, A. M. Thompson, B. Palmer, 2015, Bioorganic & medicinal chemistry letters.

Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

W. Denny, A. M. Thompson, B. Palmer, 2012, Journal of medicinal chemistry.

Structure−Activity Relationships for Amide-, Carbamate-, And Urea-Linked Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{(4-(trifluoromethoxy)benzyl)oxy}-6,7-dihydro-5H-

W. Denny, A. M. Thompson, B. Palmer, 2012 .

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

W. Denny, A. M. Thompson, B. Palmer, 2010, Journal of medicinal chemistry.

Synthesis and Structure−Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6S)‐2-Nitro-6-{[4- (trifluoromethoxy)benzyl]oxy}-6,7- dihydro‐5H‐imidazo[2,1‐b][1,3]oxazine (PA-824)

W. Denny, A. M. Thompson, B. Palmer, 2015 .

6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.

W. Denny, A. M. Thompson, B. Palmer, 2017, Bioorganic & medicinal chemistry letters.

Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.

W. Denny, B. Palmer, S. Franzblau, 2019, Bioorganic & medicinal chemistry.

Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units

Christopher B. Cooper, W. Denny, B. Palmer, 2017, Bioorganic & medicinal chemistry letters.

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Christopher B. Cooper, W. Denny, B. Palmer, 2019, Bioorganic & medicinal chemistry.

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

W. Denny, B. Palmer, S. Franzblau, 2018, Bioorganic & medicinal chemistry.

W. Denny, A. M. Thompson, B. Palmer, 2010 .