W. Wicha

发表

Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model

B. Hrvačić, S. Paukner, S. Gelone, 2021, PloS one.

Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae

S. Paukner, W. Wicha, D. Strickmann, 2019, The Journal of antimicrobial chemotherapy.

Pharmacokinetics and safety of lefamulin after single intravenous dose administration in subjects with impaired renal function and those requiring hemodialysis

T. Marbury, S. Gelone, J. Crandon, 2021, Pharmacotherapy.

Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial.

S. Paukner, G. Moran, Anita F. Das, 2019, JAMA.

Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid.

M. Zeitlinger, W. Prince, P. Matzneller, 2016, The Journal of antimicrobial chemotherapy.

Anti-inflammatory Activity of Lefamulin in a Lipopolysaccharide-Induced Lung Neutrophilia Model

B. Hrvačić, S. Paukner, S. Gelone, 2020, bioRxiv.

Pharmacokinetic/pharmacodynamic target attainment analyses to support intravenous and oral lefamulin dose selection for the treatment of patients with community-acquired bacterial pneumonia

S. Gelone, S. Bhavnani, P. Ambrose, 2019, The Journal of antimicrobial chemotherapy.

Pharmacokinetics and tolerability of lefamulin following intravenous and oral dosing

S. Gelone, W. Prince, C. Lell, 2019, The Journal of antimicrobial chemotherapy.

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial

T. File, S. Paukner, G. Talbot, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Tissue Distribution of [14C]-Lefamulin into the Urogenital Tract in Rats

S. Gelone, C. Henson, W. Wicha, 2022, Antimicrobial agents and chemotherapy.

Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections

M. Unemo, F. Franceschi, G. Drusano, 2022, Frontiers in Pharmacology.

In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection model

W. Craig, D. Andes, W. Wicha, 2019, The Journal of antimicrobial chemotherapy.

Prediction of lefamulin epithelial lining fluid penetration after intravenous and oral administration using Phase 1 data and population pharmacokinetics methods

S. Bhavnani, C. Rubino, W. Wicha, 2019, The Journal of antimicrobial chemotherapy.

Formulations pharmaceutiques injectables de lefamuline

Werner Heilmayer, W. Wicha, P. Hinsmann, 2016 .

Pharmacokinetics and safety of lefamulin after single intravenous dose administration in subjects with impaired‐hepatic function

T. Marbury, S. Gelone, J. Crandon, 2021, Pharmacotherapy.

In Vivo Immune-Modulatory Activity of Lefamulin in an Influenza Virus A (H1N1) Infection Model in Mice

S. Paukner, S. Gelone, W. Wicha, 2024, International journal of molecular sciences.