Ruiwu Wang

发表

S4153R is a gain-of-function mutation in the cardiac Ca(2+) release channel ryanodine receptor associated with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation.

G. Oudit, P. Zhabyeyev, Florian Hiess, 2013, The Canadian journal of cardiology.

S 4153 R Is a Gain-of-Function Mutation in the Cardiac Ca 2 þ Release Channel Ryanodine Receptor Associated With Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation

G. Oudit, P. Zhabyeyev, S. Chen, 2013 .

RyR 2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca 2 release ( SOICR )

Heping Cheng, Dongmei Yang, B. Xiao, 2004 .

Infanticide vs. inherited cardiac arrhythmias

R. Redon, P. Schwartz, M. Nyegaard, 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Conformational dynamics inside amino-terminal disease hotspot of ryanodine receptor.

Y. Liu, T. Wagenknecht, F. van Petegem, 2012, Structure.

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

H. Duff, A. Gillis, Heping Cheng, 2011, Nature Medicine.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

Hai Qi, Yan Shi, Tie Xia, 2022, bioRxiv.

Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Varroa destructor

J. Pettis, Zhiqi Liu, Z. Huang, 2002 .

A gain‐of‐function mutation in the ITPR1 gating domain causes male infertility in mice

M. Nyegaard, M. Overgaard, Ju Chen, 2022, Journal of cellular physiology.

Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor/calcium release channel.

Jing Zhang, Terence Wagenknecht, T. Wagenknecht, 2004, Journal of molecular biology.

RyR2 Serine-2030 PKA Site Governs Ca2+ Release Termination and Ca2+ Alternans

Wenting Guo, L. Hove-Madsen, D. Belke, 2022, Circulation research.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

D. Tieleman, Qiang Zhou, H. Duff, 2014, Nature Medicine.

Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia.

A. Wilde, W. Shimizu, M. Ackerman, 2019, Heart rhythm.

Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

Roger J. Thompson, H. T. ter Keurs, R. W. Turner, 2020, Cell reports.

Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

D. Maclennan, R. Dirksen, Wenting Guo, 2017, The Biochemical journal.

Reduced Threshold for Luminal Ca2+ Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia*

Huihui Kong, D. Jiang, B. Fruen, 2008, Journal of Biological Chemistry.

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release*

W. Chazin, M. Overgaard, Michael T Overgaard, 2015, The Journal of Biological Chemistry.

De novo ITPR1 variants are a recurrent cause of early-onset ataxia, acting via loss of channel function

S. Züchner, P. Bauer, R. Schüle, 2018, European Journal of Human Genetics.

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

Jianping Wu, N. Yan, W. Peng, 2016, Science.

Modulation of cardiac ryanodine receptor 2 by calmodulin

N. Yan, Jianlin Lei, R. Wang, 2019, Nature.

Modulation of cardiac ryanodine receptor 2 by calmodulin

N. Yan, Jianlin Lei, X. Chi, 2019, Nature.

Three-dimensional Localization of Divergent Region 3 of the Ryanodine Receptor to the Clamp-shaped Structures Adjacent to the FKBP Binding Sites*

T. Wagenknecht, Fei Li, D. Jiang, 2003, The Journal of Biological Chemistry.

Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor).

Z. Huang, K. Dong, Ruiwu Wang, 2003, Insect biochemistry and molecular biology.

Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding

Zhiqi Liu, Z. Huang, K. Dong, 2005, Molecular Pharmacology.

A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia.

A. Krahn, F. van Petegem, A. Lehman, 2017, Journal of electrocardiology.

Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain

T. Wagenknecht, Andrea Koop, Ruiwu Wang, 2013, Journal of Cell Science.

The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability

Wenting Guo, Ruiwu Wang, S. Chen, 2020, The Journal of Biological Chemistry.

The Predicted TM10 Transmembrane Sequence of the Cardiac Ca2+ Release Channel (Ryanodine Receptor) Is Crucial for Channel Activation and Gating*

Huihui Kong, Ruiwu Wang, S. Chen, 2004, Journal of Biological Chemistry.

Role of cardiac ryanodine receptor calmodulin‐binding domains in mediating the action of arrhythmogenic calmodulin N‐domain mutation N54I

M. Overgaard, Wenting Guo, Ruiwu Wang, 2019, The FEBS journal.

Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias*

H. Duff, A. Gillis, S. Fleischer, 2007, Journal of Biological Chemistry.

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

H. Duff, Huihui Kong, Y. Shimoni, 2007, Biophysical journal.

CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression

F. van Petegem, Ruiwu Wang, Yingjie Liu, 2017, PloS one.

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

F. van Petegem, Lynn Kimlicka, Florian Hiess, 2013, The Biochemical journal.

Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death

Huihui Kong, B. Xiao, D. Jiang, 2005, Circulation research.

Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome.

Jeffrey M. Vinocur, A. Wilde, A. Krahn, 2021, JAMA cardiology.

Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death

S. Priori, C. Napolitano, Wenting Guo, 2021, Bioscience reports.

Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor

T. Wagenknecht, R. Cole, N. Ikemoto, 2010, Journal of Cell Science.

Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death

D. Jiang, Wenqian Chen, Ruiwu Wang, 2007, Proceedings of the National Academy of Sciences.

Localization of a Disease-associated Mutation Site in the Three-dimensional Structure of the Cardiac Muscle Ryanodine Receptor*

T. Wagenknecht, Ruiwu Wang, S. Chen, 2005, Journal of Biological Chemistry.

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR).

Heping Cheng, Dongmei Yang, B. Xiao, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias*

Wenting Guo, T. G. Back, Ruiwu Wang, 2016, The Journal of Biological Chemistry.

Abnormal Termination of Ca2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

M. Fill, Ruiwu Wang, Yijun Tang, 2012, Circulation research.

Cardiac ryanodine receptor calcium release deficiency syndrome

S. Priori, C. Napolitano, A. Wilde, 2021, Science Translational Medicine.

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.

Ruiwu Wang, Yingjie Liu, Yijun Tang, 2013, The Biochemical journal.

Phospholamban Knockout Breaks Arrhythmogenic Ca2+ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice

H. Duff, Long-Sheng Song, R. Clark, 2013, Circulation research.

Modulation of cardiac ryanodine receptor 2 by calmodulin

N. Yan, Jianlin Lei, X. Chi, 2019, Nature.

Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.

Wenjun Zheng, Z. Yuchi, Qian Zhao, 2018, Journal of molecular and cellular cardiology.

Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor.

Wenting Guo, Florian Hiess, Ruiwu Wang, 2015, The Biochemical journal.

The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor*

Wenting Guo, Ruiwu Wang, Yingjie Liu, 2015, The Journal of Biological Chemistry.

Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis

Y. Einav, O. Shor, D. Luria, 2021, Journal of the American Heart Association.

Residue Gln4863 within a Predicted Transmembrane Sequence of the Ca2+ Release Channel (Ryanodine Receptor) Is Critical for Ryanodine Interaction*

A. J. Williams, W. Welch, Ni Diao, 2003, Journal of Biological Chemistry.

Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice

T. G. Back, Ruiwu Wang, S. R. Wayne Chen, 2021, Neuroscience Letters.

Localization of the 12.6-kDa FK506-binding Protein (FKBP12.6) Binding Site to the NH2-terminal Domain of the Cardiac Ca2+ Release Channel (Ryanodine Receptor)*

B. Xiao, H. Masumiya, Ruiwu Wang, 2003, The Journal of Biological Chemistry.

Isoform-dependent Formation of Heteromeric Ca2+ Release Channels (Ryanodine Receptors)*

T. Wagenknecht, T. Murayama, Y. Sei, 2002, The Journal of Biological Chemistry.

Human RyR2 (Ryanodine Receptor 2) Loss-of-Function Mutations

A. Wilde, M. Gollob, Jason D. Roberts, 2021, Circulation. Arrhythmia and electrophysiology.

Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart.

E. Alvarez-Lacalle, B. Echebarria, Wenting Guo, 2020, Circulation research.

The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts

Wenting Guo, L. Hove-Madsen, Ruiwu Wang, 2018, The Journal of Biological Chemistry.

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

H. Duff, A. Gillis, Long-Sheng Song, 2016, The Biochemical journal.

Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes*

H. T. ter Keurs, Hongqiang Cheng, Ju Chen, 2015, The Journal of Biological Chemistry.

Molecular Mechanism of Conductance Enhancement in Narrow Cation-Selective Membrane Channels.

Williams E. Miranda, S. Noskov, Van A. Ngo, 2018, The journal of physical chemistry letters.

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

Michael Fill, Christian Holt, Michael Toft Overgaard, 2016, The Journal of Biological Chemistry.

The Gln4863Ala Mutation within a Putative, Pore-Lining Trans-Membrane Helix of the Cardiac Ryanodine Receptor Channel Alters Both the Kinetics of Ryanoid Interaction and the Subsequent Fractional Conductance

A. J. Williams, W. Welch, K. M. Ranatunga, 2005, Molecular Pharmacology.

Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.

A. J. Williams, W. Welch, Ruiwu Wang, 2009, Biophysical journal.

Ligand-dependent Conformational Changes in the Clamp Region of the Cardiac Ryanodine Receptor*

T. Wagenknecht, Ruiwu Wang, Yingjie Liu, 2012, The Journal of Biological Chemistry.

Localization of an NH2-terminal Disease-causing Mutation Hot Spot to the “Clamp” Region in the Three-dimensional Structure of the Cardiac Ryanodine Receptor*

T. Wagenknecht, Wenqian Chen, Ruiwu Wang, 2007, Journal of Biological Chemistry.

RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation

Wenting Guo, Ruiwu Wang, S. Chen, 2021, The Journal of biological chemistry.

The Cytoplasmic Region of Inner Helix S6 Is an Important Determinant of Cardiac Ryanodine Receptor Channel Gating*

Wenting Guo, Ruiwu Wang, S. Chen, 2016, The Journal of Biological Chemistry.

The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor

F. van Petegem, Wenting Guo, Ruiwu Wang, 2015, PloS one.

Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor*

T. Wagenknecht, Xing Meng, B. Fruen, 2011, The Journal of Biological Chemistry.

Increased Ca2+ Transient Underlies RyR2-Related Left Ventricular Noncompaction

A. Lehman, Ju Chen, S. Sanatani, 2023, Circulation research.

Generation and Characterization of a Mouse Model Harboring the Exon-3 Deletion in the Cardiac Ryanodine Receptor

James D. Johnson, A. Gillis, Ju Chen, 2014, PloS one.

Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome

M. Ginks, H. Watkins, Jenny C. Taylor, 2021, Circulation. Genomic and precision medicine.

K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association.

Y. Shimoni, Keyun Chen, Wenqian Chen, 2007, The Biochemical journal.

K 201 ( JTV 519 ) suppresses spontaneous Ca 2 + release and [ 3 H ] ryanodine binding to RyR 2 irrespective of FKBP 12 . 6 association

Y. Shimoni, Keyun Chen, Wenqian Chen, 2007 .

Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

Zizhen Zhang, H. T. ter Keurs, P. Stys, 2022, Communications Biology.

Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+ Release Activation and Termination*

F. van Petegem, Wenting Guo, Ruiwu Wang, 2015, The Journal of Biological Chemistry.

A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity

Ruiwu Wang, Shanshan Tian, S. Chen, 2023, Neuroscience.

De novo ITPR1 variants are a recurrent cause of early-onset ataxia, acting via loss of channel function

S. Züchner, P. Bauer, R. Schüle, 2018, European Journal of Human Genetics.

Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor.

Wenting Guo, Florian Hiess, Ruiwu Wang, 2015, The Biochemical journal.

Abnormal Termination of Ca2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

M. Fill, Ruiwu Wang, Yijun Tang, 2012, Circulation research.

Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells

Yan Shi, Bin Zhang, Junchen Meng, 2023, The Journal of clinical investigation.

The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts

Wenting Guo, L. Hove-Madsen, Ruiwu Wang, 2018, The Journal of Biological Chemistry.

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

Lynn Kimlicka, Florian Hiess, Ruiwu Wang, 2013, The Biochemical journal.

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca 2 (cid:2) Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor *

M. Overgaard, C. Holt, M. Fill, 2017 .

A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome.

P. Postema, F. Sacher, L. Gula, 2024, JAMA.