Lei Zhang

发表

A cobalt-catalyzed alkene hydroboration with pinacolborane.

Zheng Huang, X. Leng, Lei Zhang, 2014, Angewandte Chemie.

Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.

R. Oballa, R. Gordon, J. Guay, 2011, Bioorganic & medicinal chemistry letters.

Site-Selective Acceptorless Dehydrogenation of Aliphatics Enabled by Organophotoredox/Cobalt Dual Catalysis.

Zheng Huang, Lei Zhang, Chen Xu, 2021, Journal of the American Chemical Society.

Preferential inhibition of human phosphodiesterase 4 by ibudilast.

Y. Natsumeda, M. Salem, Zheng Huang, 2006, Life sciences.

Cobalt-Catalyzed Borylation of Aryl Halides and Pseudohalides

A. Hu, Zheng Huang, Huanan Wen, 2016 .

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.

J. Falgueyret, R. Oballa, J. Guay, 2011, Bioorganic & medicinal chemistry letters.

Iron-catalyzed, atom-economical, chemo- and regioselective alkene hydroboration with pinacolborane.

Zheng Huang, X. Leng, Lei Zhang, 2013, Angewandte Chemie.

A highly efficient cobalt-catalyzed deuterogenolysis of diboron: Synthesis of deuterated pinacolborane and vinylboronates

Zheng Huang, Lei Zhang, Guixia Liu, 2019, Tetrahedron.

Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.

J. Guay, C. Li, Yeeman K. Ramtohul, 2009, Bioorganic & medicinal chemistry letters.

Dynamic Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Type 3 and Type 4D Phosphodiesterase Inhibitors

M. Tota, A. Veilleux, R. Friesen, 2005, Journal of Pharmacology and Experimental Therapeutics.

SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.

R. Oballa, J. Guay, Sébastien Guiral, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

J. Falgueyret, R. Oballa, J. Guay, 2010, Bioorganic & medicinal chemistry letters.

Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

R. Oballa, K. Bateman, C. Li, 2011, Journal of Lipid Research.

2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.

J. Falgueyret, R. Oballa, P. Tawa, 2010, Bioorganic & medicinal chemistry letters.

A Multiplexed Cell Assay in HepG2 Cells for the Identification of Delta-5, Delta-6, and Delta-9 Desaturase and Elongase Inhibitors

J. Guay, S. Gagné, A. Styhler, 2010, Journal of biomolecular screening.

Phosphinite-iminopyridine iron catalysts for chemoselective alkene hydrosilylation.

Xiaoyong Du, M. Walter, Zheng Huang, 2013, Journal of the American Chemical Society.

Selective synthesis of secondary benzylic (Z)-allylboronates by Fe-catalyzed 1,4-hydroboration of 1-aryl-substituted 1,3-dienes

Zheng Huang, X. Leng, Dan Zhang, 2014 .

Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.

David A. Powell, Lei Zhang, R. Oballa, 2011, Journal of medicinal chemistry.

Cobalt-catalyzed enantioselective hydroboration of 1,1-disubstituted aryl alkenes.

Zheng Huang, Lei Zhang, Ziqing Zuo, 2014, Journal of the American Chemical Society.

Pincer Iron Hydride Complexes for Alkene Isomerization: Catalytic Approach to Trisubstituted (Z)-Alkenyl Boronates

Zheng Huang, Yinlong Guo, Lei Zhang, 2021, ACS Catalysis.

Synthesis of 1,1,1-Tris(boronates) from Vinylarenes by Co-Catalyzed Dehydrogenative Borylations-Hydroboration.

Zheng Huang, Lei Zhang, 2015, Journal of the American Chemical Society.

Iridium complexes of new NCP pincer ligands: catalytic alkane dehydrogenation and alkene isomerization.

Xiangqing Jia, Zheng Huang, X. Leng, 2014, Chemical communications.

Iron-catalyzed asymmetric hydrosilylation of ketones.

Zheng Huang, X. Leng, Lei Zhang, 2015, Chemical communications.

Iron‐Catalyzed, Atom‐Economical, Chemo‐ and Regioselective Alkene Hydroboration with Pinacolborane.

Zheng Huang, X. Leng, Lei Zhang, 2013 .

Stereoselective Synthesis of Trisubstituted Alkenes via Cobalt-Catalyzed Double Dehydrogenative Borylations of 1-Alkenes

Zheng Huang, Huanan Wen, Lei Zhang, 2017 .

Ultrathin scroll-like CdSe/CdS core/crown heteronanoplatelets: Colloidal synthesis and properties

Z. Huang, Huiyuan Bai, Lei Zhang, 2022, Colloids and Surfaces A: Physicochemical and Engineering Aspects.

Synthesis of 1,1,1‐Tris(boronates) from Vinylarenes by Co‐Catalyzed Dehydrogenative Borylations—Hydroboration.

Zheng Huang, Lei Zhang, 2016 .

Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.

R. Oballa, S. Léger, Sébastien Guiral, 2012, Bioorganic & medicinal chemistry letters.

Cobalt-Catalyzed Asymmetric Hydrogenation of Vinylsilanes with a Phosphine–Pyridine–Oxazoline Ligand: Synthesis of Optically Active Organosilanes and Silacycles

Zheng Huang, Lan Gan, Lei Zhang, 2019, Organometallics.

Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.

Lei Zhang, Serge Leger, Jean-Philippe Leclerc, 2011, Bioorganic & medicinal chemistry letters.

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.

R. Oballa, R. Gordon, J. Guay, 2011, Bioorganic & medicinal chemistry letters.

A Multiplexed Cell Assay in HepG2 Cells for the Identification of Delta-5, Delta-6, and Delta-9 Desaturase and Elongase Inhibitors

J. Guay, S. Gagné, A. Styhler, 2010, Journal of biomolecular screening.