S. Regunathan

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Repeated immobilization stress alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels

Wei-Ping Wang, G. Bissette, Yangzheng Feng, 2008, Neurochemistry International.

Is agmatine a novel neurotransmitter in brain?

D. Reis, S. Regunathan, 2000, Trends in pharmacological sciences.

Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.

D. Reis, R. Yezierski, K. Brewer, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY.

D. Reis, C. Wahlestedt, S. Regunathan, 1992, Life sciences.

Effect of α-methylserotonin on serotonin receptor-coupled phosphoinositide breakdown in rat cerebral cortex

T. Sourkes, S. Regunathan, 1990, Neurochemistry International.

Distribution of Imidazoline Receptor Binding Protein in the Central Nervous System

D. Reis, T. Milner, D. Ruggiero, 1995, Annals of the New York Academy of Sciences.

Expression of non‐adrenergic imidazoline sites in rat cerebral cortical astrocytes

D. Reis, D. Feinstein, S. Regunathan, 1993, Journal of neuroscience research.

Mammalian adrenal chromaffin cells coexpress the epinephrine-synthesizing enzyme and neuronal properties in vivo and in vitro.

M. Ehrlich, G. Teitelman, S. Regunathan, 1994, Developmental biology.

Protection of focal ischemic infarction by rilmenidine in the animal: evidence that interactions with central imidazoline receptors may be neuroprotective.

E. Golanov, D. Reis, D. Feinstein, 1994, The American journal of cardiology.

Stimulation of imidazoline receptors inhibits proliferation of human coronary artery vascular smooth muscle cells.

D. Reis, S. Regunathan, 1997, Hypertension.

Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines.

D. Reis, D. Feinstein, E. Galea, 1998, The Biochemical journal.

Imidazoline receptor proteins are regulated in platelet-precursor MEG-01 cells by agonists and antagonists.

D. Reis, J. C. Jones, J. Piletz, 1998, Journal of psychiatric research.

Regulation of Phenylethanolamine N‐Methyltransferase Gene Expression by Imidazoline Receptors in Adrenal Chromaffin Cells

D. Reis, P. Ernsberger, S. Regunathan, 1995, Journal of neurochemistry.

Agmatine: an endogenous ligand at imidazoline receptors may be a novel neurotransmitter in brain.

D. Reis, S. Regunathan, 1998, Journal of the autonomic nervous system.

Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine.

D. Reis, D. Feinstein, E. Galea, 1996, The Biochemical journal.

Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes

D. Reis, D. Feinstein, W. Raasch, 1995, Neuroreport.

Agmatine: an endogenous clonidine-displacing substance in the brain.

D. Reis, C. Barrow, S. Regunathan, 1994, Science.

Imidazoline Receptors in the Heart: Characterization, Distribution, and Regulation

J. Gutkowska, S. Mukaddam‐Daher, R. El-Ayoubi, 2002, Journal of cardiovascular pharmacology.

Anti‐Proliferative and Anti‐Inflammatory Actions of Imidazoline Agents: Are Imidazoline Receptors Involved?

D. Reis, D. Feinstein, S. Regunathan, 1999, Annals of the New York Academy of Sciences.

Agmatine: An Endogenous Ligand at Imidazoline Receptors Is a Novel Neurotransmitter a

D. Reis, S. Regunathan, 1999, Annals of the New York Academy of Sciences.

Inhibition of astroglial nitric oxide synthase type 2 expression by idazoxan.

D. Reis, D. Feinstein, S. Regunathan, 1999, Molecular pharmacology.

Endogenous Ligands of Imidazoline Receptors: Classic and Immunoreactive Clonidine‐Displacing Substance and Agmatine

D. Reis, S. Regunathan, G. Li, 1995, Annals of the New York Academy of Sciences.

Effects of Rilmenidine on Signal Transduction Mechanisms Associated with α2‐Adrenergic and Imidazoline Receptors in Brain

D. Reis, S. Bramwell, S. Regunathan, 1995, Annals of the New York Academy of Sciences.

Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues

D. Reis, P. Escribá, M. Sastre, 1994, Neuroscience Letters.

Production and characterization of antibodies specific for the imidazoline receptor protein.

D. Reis, D. Ruggiero, S. Regunathan, 1993, Molecular pharmacology.

Isolation and characterization of imidazoline receptor protein from bovine adrenal chromaffin cells.

D. Reis, M. P. Meeley, S. Regunathan, 1992, Molecular pharmacology.

Clonidine-displacing substance from bovine brain binds to imidazoline receptors and releases catecholamines in adrenal chromaffin cells.

D. Reis, M. P. Meeley, S. Regunathan, 1991, Molecular pharmacology.

Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells.

D. Reis, M. P. Meeley, S. Regunathan, 1991, Biochemical pharmacology.

Uptake of Agmatine into Rat Brain Synaptosomes: Possible Role of Cation Channels

D. Reis, M. Sastre, S. Regunathan, 1997, Journal of neurochemistry.

Regulation of Inducible Nitric Oxide Synthase and Agmatine Synthesis in Macrophages and Astrocytes

J. Piletz, S. Regunathan, 2003, Annals of the New York Academy of Sciences.

Specific binding of inositol hexakisphosphate (phytic acid) to adrenal chromaffin cell membranes and effects on calcium-dependent catecholamine release.

D. Reis, C. Wahlestedt, S. Regunathan, 1992, Biochemical pharmacology.

PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version www.pdflib.com – sales@pdflib.com Imidazoline Receptors in Vascular Smooth Muscle and Endothelial Cells"

D. Reis, S. Regunathan, Hong Wang, 2008 .

Co-detection by two imidazoline receptor protein antisera of a novel 85 kilodalton protein.

D. Reis, J. Piletz, M. Dontenwill, 1998, Biochemical pharmacology.

An antiserum to idazoxan recognizes an immunoreactive substance in human serum and cerebral spinal fluid which is not agmatine

D. Reis, S. Bramwell, S. Regunathan, 1997, Neurochemistry International.

Imidazoline Receptors in Vascular Smooth Muscle and Endothelial Cells fn1

D. Reis, S. Regunathan, Hong Wang, 1995, Annals of the New York Academy of Sciences.

Coexpression of Imidazoline Receptors and Agmatine in Rat Carotid Body

D. Reis, S. Regunathan, Hong Wang, 1995, Annals of the New York Academy of Sciences.

Imidazoline receptors and their endogenous ligands.

D. Reis, S. Regunathan, D. J. Reis, 1996, Annual review of pharmacology and toxicology.

Agmatine, the bacterial amine, is widely distributed in mammalian tissues.

D. Reis, S. Regunathan, W. Raasch, 1995, Life sciences.

Glutamate metabolism in the brain of young rats exposed to organic and inorganic lead

S. Regunathan, R. Sundaresan, 1985, Neurochemistry International.

Effects of Organic and Inorganic Lead on Synaptosomal Uptake, Release, and Receptor Binding of Glutamate in Young Rats

S. Regunathan, R. Sundaresan, 1985, Journal of neurochemistry.

Pyruvate Metabolism in the Brain of Young Rats Intoxicated with Organic and Inorganic Lead

S. Regunathan, R. Sundaresan, 1984, Journal of neurochemistry.

Incorporation of 14C from glucose into amino acids in brain in vitro in the presence of organo- and inorganic lead and pyridoxal phosphate.

S. Regunathan, R. Sundaresan, 1983, Life sciences.

Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: A potential mechanism for the anticonvulsive effects

Yangzheng Feng, S. Regunathan, M. Leblanc, 2005, Neuroscience Letters.

Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice

I. Paul, F. Aricioglu, S. Regunathan, 2004, Neuroscience Letters.

Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation.

D. Reis, S. Regunathan, C. Youngson, 1996, The Journal of pharmacology and experimental therapeutics.

Expression of arginine decarboxylase in brain regions and neuronal cells

G. Ordway, Meng-Yang Zhu, A. Iyo, 2006, Journal of neurochemistry.

Agmatinase Activity in Rat Brain: A Metabolic Pathway for the Degradation of Agmatine

D. Reis, E. Galea, M. Sastre, 1996, Journal of neurochemistry.

Localization of Agmatine in Vasopressin and Oxytocin Neurons of the Rat Hypothalamic Paraventricular and Supraoptic Nuclei

D. Reis, O. Gorbatyuk, T. Milner, 2001, Experimental Neurology.

Agmatine Reduces Alcohol Drinking and Produces Antinociceptive Effects in Rodent Models of Alcohol Use Disorder.

H. Becker, S. Regunathan, Marcelo F. Lopez, 2023, Alcohol.

Regional localization of agmatine in the rat brain: an immunocytochemical study

D. Reis, D. Ruggiero, K. Otake, 1998, Brain Research.

Cardiovascular responses to agmatine, a clonidine-displacing substance, in anesthetized rat.

D. Reis, M. Sun, S. Regunathan, 1995, Clinical and experimental hypertension.

Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine.

J. Piletz, Meng-Yang Zhu, A. Iyo, 2004, Biochimica et biophysica acta.

Characterization of Arginine Decarboxylase in Rat Brain and Liver

D. Reis, S. Regunathan, 2000, Journal of neurochemistry.

Agmatine Levels in the Cerebrospinal Fluid of Normal Human Volunteers

S. Regunathan, W. Phillips, Damon A. Dozier, 2009, Journal of pain & palliative care pharmacotherapy.

Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain.

G. Ordway, Wei-Ping Wang, Meng-Yang Zhu, 2008, The European journal of neuroscience.

Agmatine: Biological role and therapeutic potentials in morphine analgesia and dependence

S. Regunathan, 2006, The AAPS Journal.

Agmatine: a novel neurotransmitter?

D. Reis, S. Regunathan, 1998, Advances in pharmacology.

Central Regulation of Adrenal Tyrosine Hydroxylase: Effect of Induction on Catecholamine Levels in the Adrenal Medulla and Plasma

T. Sourkes, K. Missala, S. Regunathan, 1989, Journal of neurochemistry.

Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus

M. Austin, A. Feyissa, A. Iyo, 2010, Neuroscience.

Chronic treatment with glucocorticoids alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels

Wei-Ping Wang, Meng-Yang Zhu, Jingjing Huang, 2007, Journal of neurochemistry.

Central regulation of adrenal tyrosine hydroxylase: Interaction between dopamine and GABA systems

T. Sourkes, S. Regunathan, R. Gabor, 1989, Neuropharmacology.

Effect of vasopressin on the induction of adrenal tyrosine hydroxylase and phenylethanolamine N-methyltransferase

T. Sourkes, S. Regunathan, 1988, Regulatory Peptides.

Immunocytochemical localization of an imidazoline receptor protein in the central nervous system

D. Reis, T. Milner, D. Ruggiero, 1998, Brain Research.

Anticholinesterase activity of prolactin: correlation with analgesia

S. Ramaswamy, J. S. Bapna, S. Regunathan, 1988, The Journal of pharmacy and pharmacology.

L 3 ‐ IMIDAZOLINE RECEPTORS IN THE NERVOUS SYSTEM

D. Reis, D. Feinstein, M. P. Meeley, 1992, Fundamental & clinical pharmacology.

Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats

F. Aricioglu, S. Regunathan, T. Utkan, 2012, Pharmacology Biochemistry and Behavior.

Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies.

D. L. Robinson, F. Sohrabji, P. Molina, 2016, Alcoholism, clinical and experimental research.

A single transmitter regulates gene expression through two separate mechanisms: cholinergic regulation of phenylethanolamine N- methyltransferase mRNA via nicotinic and muscarinic pathways

P. Ernsberger, S. Regunathan, D. Reis, 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons

Wei-Ping Wang, Meng-Yang Zhu, A. Iyo, 2006, Brain Research.

Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery

D. Reis, C. Estrada, C. González, 1996, British journal of pharmacology.

Expression of I2-imidazoline sites in rat prostate. Effect of castration and aging.

D. Reis, E. Vaughan, D. Felsen, 1996, Biochemical pharmacology.

Agmatine attenuates stress- and lipopolysaccharide-induced fever in rats

F. Aricioglu, S. Regunathan, 2005, Physiology & Behavior.

Neural mechanisms of pain and alcohol dependence

A. Apkarian, J. Levine, V. Neugebauer, 2013, Pharmacology Biochemistry and Behavior.

Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system.

F. Aricioglu, S. Regunathan, Andrea Means, 2004, European journal of pharmacology.

Effects of moxonidine, an imidazoline antihypertensive agent, on second messenger systems in rat brain.

D. Reis, S. Regunathan, 1994, European journal of pharmacology.

Effect of clonidine on second messenger systems in rat adrenal gland.

D. Reis, M. P. Meeley, S. Regunathan, 1990, Life sciences.

Imidazole receptors and clonidine-displacing substance in relationship to control of blood pressure, neuroprotection, and adrenomedullary secretion.

D. Reis, M. P. Meeley, S. Regunathan, 1992, American journal of hypertension.

Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues.

S. Regunathan, F. Aricioglu-Kartal, 2002, Life sciences.

Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation on vasopressin release and Ca2+ channels

D. Reis, O. Gorbatyuk, T. Milner, 2002, Brain Research.

Expression of non-adrenergic imidazoline sites in chromaffin cells and mitochondrial membranes of bovine adrenal medulla.

D. Reis, M. P. Meeley, S. Regunathan, 1993, Biochemical pharmacology.

Is Agmatine an Endogenous Factor Against Stress?

F. Aricioglu, S. Regunathan, JOHN E. PILETZ, 2003, Annals of the New York Academy of Sciences.

Effect of Agmatine Against Cell Death Induced by NMDA and Glutamate in Neurons and PC12 Cells

J. Piletz, A. Halaris, Meng-Yang Zhu, 2003, Cellular and Molecular Neurobiology.

Structure‐Activity Analysis of Guanidine Group in Agmatine for Brain Agmatinase

M. Botta, D. Berkowitz, K. Lee, 2003, Annals of the New York Academy of Sciences.

Castration of Rats Upregulates the Imidazoline Receptor in Prostate

E. Vaughan, D. Felsen, Y. Nassir, 1995, Annals of the New York Academy of Sciences.

An antibody to agmatine localizes the amine in bovine adrenal chromaffin cells

D. Reis, S. Bramwell, S. Regunathan, 1995, Neuroscience Letters.

Agmatine Is Synthesized by a Mitochondrial Arginine Decarboxylase in Rat Brain

D. Reis, S. Regunathan, Gen Li, 1995, Annals of the New York Academy of Sciences.

Agmatine Is Widely and Unequally Distributed in Rat Organs

D. Reis, W. Raasch, S. Regunathan, 1995, Annals of the New York Academy of Sciences.