M. Depré

发表

Does the Unfavorable Pharmacokinetic and Pharmacodynamic Profile of the iNOS Inhibitor GW273629 Lead to Inefficacy in Acute Migraine?

F. Vanmolkot, B. Laurijssens, J. Palmer, 2009, Journal of clinical pharmacology.

Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).

W. S. Denney, B. Van der Schueren, T. Ho, 2010, British journal of clinical pharmacology.

Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once‐Weekly Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitor, After Single and Multiple Doses in Healthy Subjects

D. Tatosian, J. Wagner, R. Krishna, 2016, Journal of clinical pharmacology.

Co-creation with research participants to inform the design of electronic informed consent

I. Huys, P. Borry, E. De Sutter, 2022, Digital health.

Single‐Dose and Multiple‐Dose Pharmacokinetics of Vaniprevir in Healthy Men

J. Miller, J. Butterton, D. Panebianco, 2017, Clinical and translational science.

Pharmacokinetics and pharmacodynamics of multiple oral doses of MK‐0591, a 5‐lipoxygenase—activating protein inhibitor

A. van Hecken, I. de Lepeleire, A. Porras, 1994, Clinical pharmacology and therapeutics.

Biochemical activity, pharmacokinetics, and tolerability of MK‐886, a leukotriene biosynthesis inhibitor, in humans

P. Deschepper, A. Hecken, M. Depré, 1993, Clinical pharmacology and therapeutics.

Multiple‐Dose Pharmacokinetics, Pharmacodynamics, and Safety of Taranabant, a Novel Selective Cannabinoid‐1 Receptor Inverse Agonist, in Healthy Male Volunteers

P. Rothenberg, J. Wagner, K. Gottesdiener, 2008, Journal of clinical pharmacology.

Effect of Multiple Doses of Montelukast, a CysLT1 Receptor Antagonist, on Digoxin Pharmacokinetics in Healthy Volunteers

B. Gertz, R. Verbesselt, A. Hecken, 1999, Journal of clinical pharmacology.

Effect of Montelukast on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers

B. Gertz, J. Arnout, P. Wong, 1999, Journal of clinical pharmacology.

Moexipril does not alter the pharmacokinetics or pharmacodynamics of warfarin

W. Cawello, R. Verbesselt, A. Hecken, 2004, European Journal of Clinical Pharmacology.

The effect of mk-591, a potent oral leukotriene biosynthesis inhibitor, on allergen-induced airway responses in asthmatic subjects

P. Sterk, Z. Diamant, E. Bel, 1993 .

Ex vivo assays demonstrate potency and selectivity of the COX-2 inhibitor DFP after single dose administration

K. Gottesdiener, A. van Hecken, I. de Lepeleire, 1999, Inflammation Research.

Plasma drug profiles and tolerability of MK-571 (L-660,711), a leukotriene D4 receptor antagonist, in man

D. Margolskee, A. Hecken, M. Depré, 2005, European Journal of Clinical Pharmacology.

Dose-dependent kinetics of the enantiomers of MK-571, an LTD4-receptor antagonist

D. Margolskee, A. Hecken, M. Depré, 2005, European Journal of Clinical Pharmacology.

The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo.

P. Sterk, E. Bel, Z. Diamant, 1995, The Journal of allergy and clinical immunology.

A randomized clinical trial comparing point-of-care platelet function assays and bleeding time in healthy subjects treated with aspirin or clopidogrel

C. Beals, J. Bolognese, M. Jacquemin, 2012, Platelets.

Pharmacokinetics, Pharmacodynamics, and Safety of a Prostaglandin D2 Receptor Antagonist

G. O'neill, F. Liu, H. Greenberg, 2008, Clinical pharmacology and therapeutics.

Pharmacokinetics, Pharmacodynamics, and Safety of a Prostaglandin D 2 Receptor

H. Greenberg, K. Metters, J. Wagner, 2007 .

Effects of enteric‐coated, low‐dose aspirin on parameters of platelet function

J. Arnout, K. Gottesdiener, A. van Hecken, 2002, Alimentary pharmacology & therapeutics.

Brain CB-1 receptor occupancy of taranabant in lean subjects using CB-1R PET

P. Dupont, L. Mortelmans, G. Bormans, 2007 .

First‐in‐human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan

A. van Hecken, L. Buntinx, M. Depré, 2022, Clinical and translational science.

Lack of hemodynamic interaction between CGRP-receptor antagonist telcagepant (MK-0974) and sumatriptan: Results from a randomized study in patients with migraine

D. Panebianco, J. Palcza, M. Murphy, 2013, Cephalalgia : an international journal of headache.

The effect of MK-0524, a prostaglandin D2 receptor antagonist, on prostaglandin D2-induced nasal airway obstruction in healthy volunteers

P. Deutsch, K. Gottesdiener, K. Mazina, 2007, European Journal of Clinical Pharmacology.

The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.

Sandra M. Sanabria-Bohórquez, E. Ravussin, S. Heymsfield, 2008, Cell metabolism.

Translational studies with [11C]MK-3168, a PET tracer for fatty acid amide hydrolase (FAAH)

G. Bormans, A. Joshi, K. Laere, 2012 .

Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion.

Geert Verreck, G. Verreck, J. Peeters, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comparative Inhibitory Activity of Rofecoxib, Meloxicam, Diclofenac, Ibuprofen, and Naproxen on COX‐2 versus COX‐1 in Healthy Volunteers

B. Gertz, J. Arnout, J. Schwartz, 2000, Journal of clinical pharmacology.

Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use

M. Gerin, R. Verbesselt, A. Hecken, 1992, Fundamental & clinical pharmacology.

Effect of aprepitant on the pharmacokinetics and pharmacodynamics of warfarin

P. Rothenberg, A. Bergman, D. Panebianco, 2005, European Journal of Clinical Pharmacology.

Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.

W. S. Denney, J. Palcza, M. Murphy, 2015, British journal of clinical pharmacology.

The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.

B. Van der Schueren, J. Palcza, M. Murphy, 2011, British journal of clinical pharmacology.

Calcitonin Gene-Related Peptide8-37 Antagonizes Capsaicin-Induced Vasodilation in the Skin: Evaluation of a Human in Vivo Pharmacodynamic Model

B. Van der Schueren, F. Vanmolkot, A. Rogiers, 2008, Journal of Pharmacology and Experimental Therapeutics.

Lack of effect of flunarizine on the pharmacokinetics and pharmacodynamics of sumatriptan in healthy volunteers.

L. Lacey, P. Fowler, A. van Hecken, 1992, British journal of clinical pharmacology.

Reproducibility of the capsaicin-induced dermal blood flow response as assessed by laser Doppler perfusion imaging.

B. Van der Schueren, F. Vanmolkot, A. van Hecken, 2007, British journal of clinical pharmacology.

Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [18F]JNJ-64413739 PET and MRA-driven image derived input function

K. Van Laere, M. Koole, J. D. de Hoon, 2021, Scientific Reports.

Pharmacokinetics, COX-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans

A. van Hecken, I. de Lepeleire, P. Wong, 2000, European Journal of Clinical Pharmacology.

Evaluation of [18F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human

Hisashi Ohta, Koen Van Laere, Osamu Okamoto, 2013, NeuroImage.

Demonstration of specific COX‐2 inhibition by MK‐966 in humans with supratherapeutic doses

B. Gertz, E. Ehrich, A. van Hecken, 1999 .

Pharmacokinetic and pharmacodynamic assessments of atogepant in healthy male adults: Results from phase 1 studies

Jialin Xu, C. Matthews, R. Boinpally, 2023, Cephalalgia Reports.

No arguments for increased endothelial nitric oxide synthase activity in migraine based on peripheral biomarkers

B. Van der Schueren, F. Verbrugge, J. D. de Hoon, 2010, Cephalalgia : an international journal of headache.

Characterization of the novel GlyT1 PET tracer [18F]MK‐6577 in humans

Guy Bormans, Michel Koole, Sandra M. Sanabria-Bohórquez, 2015, Synapse.

11C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists

Sandra M. Sanabria-Bohórquez, G. Bormans, J. Renger, 2014, The Journal of Nuclear Medicine.