Vasco Sequeira

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Chapter 6 A novel HCM mutation in cardiac troponin T primarily alters cross-bridge kinetics and increases the energetic cost of tension generation in human cardiac tissue

C. Poggesi, Steven B Marston, C. Redwood, 2014 .

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

C. D. dos Remedios, J. van der Velden, P. Wijnker, 2014, Archives of biochemistry and biophysics.

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

M. Mayr, S. Heymans, J. Balligand, 2018, Cardiovascular research.

PKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis

Pingbo Zhang, C. D. dos Remedios, J. V. Van Eyk, 2013, PloS one.

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

F. T. ten Cate, C. D. dos Remedios, C. Poggesi, 2013, Circulation research.

Hungry Hearts.

C. Maack, Edoardo Bertero, Vasco Sequeira, 2018, Circulation. Heart failure.

GSK3&bgr; Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human: Short Communication

Jeroen A. A. Demmers, C. D. dos Remedios, S. Sadayappan, 2012, Circulation research.

Energetic drain driving hypertrophic cardiomyopathy

C. Maack, Vasco Sequeira, E. Bertero, 2019, FEBS letters.

How low should we go on low-carbohydrate diets?

C. Maack, Vasco Sequeira, E. Bertero, 2019, European heart journal.

Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.

L. Carrier, D. Kuster, J. van der Velden, 2016, Cardiovascular research.

The failing heart : an engine operating on “ bad fuel ”

J. Velden, Vasco Sequeira, 2022 .

Assessing Rodent Cardiac Function in vivo Using Hemodynamic Pressure-Volume Loops

I. Falcão-Pires, A. Lourenço, Vasco Sequeira, 2022, Frontiers in Physiology.

Response to 'The possible role of insulin and glucagon in patients with heart failure and Type 2 diabetes'.

S. Heymans, C. Maack, Vasco Sequeira, 2020, European heart journal.

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy

C. D. dos Remedios, B. Knollmann, C. Redwood, 2022, Journal of molecular and cellular cardiology plus.

Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure–function relationships

D. Kuster, J. van der Velden, E. R. Witjas-Paalberends, 2013, Pflügers Archiv - European Journal of Physiology.

β‐adrenergic receptor signalling and its functional consequences in the diseased heart

D. Kuster, J. Velden, Vasco Sequeira, 2016, European journal of clinical investigation.

Historical perspective on heart function: the Frank–Starling Law

J. van der Velden, J. Velden, Vasco Sequeira, 2015, Biophysical Reviews.

The Frank–Starling Law: a jigsaw of titin proportions

Vasco Sequeira, J. van der Velden, Jolanda van der Velden, 2017, Biophysical Reviews.

The physiological role of cardiac cytoskeleton and its alterations in heart failure.

J. van der Velden, J. Regan, Vasco Sequeira, 2014, Biochimica et biophysica acta.

The Interplay between S-Glutathionylation and Phosphorylation of Cardiac Troponin I and Myosin Binding Protein C in End-Stage Human Failing Hearts

H. Mannherz, L. Leichert, A. Mügge, 2021, Antioxidants.

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

C. D. dos Remedios, M. Michels, D. Kuster, 2015, Proceedings of the National Academy of Sciences.

Metabolic Alterations in Inherited Cardiomyopathies

Jan Dudek, C. Maack, M. Calore, 2019, Journal of clinical medicine.

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.

D. Kuster, P. Wijnker, J. Velden, 2019, Antioxidants & redox signaling.

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

C. Ottenheijm, A. Beggs, N. Clarke, 2015, Skeletal Muscle.

Distinctive patterns of inflammation across the heart failure syndrome

P. Ameri, G. Schiattarella, Vasco Sequeira, 2020, Heart Failure Reviews.

CaMKII does not control mitochondrial Ca2+ uptake in cardiac myocytes

J. Backs, Jan Dudek, M. Kohlhaas, 2020, The Journal of physiology.

Loss of Mitochondrial Ca2+ Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy

U. Laufs, Jan Dudek, P. Rehling, 2021, Circulation.

Reduced left ventricular contractility, increased diastolic operant stiffness and high energetic expenditure in patients with severe aortic regurgitation without indication for surgery.

H. Schäfers, J. Borer, H. Sievers, 2020, Interactive cardiovascular and thoracic surgery.

CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect

P. Steendijk, L. Maier, D. Dobrev, 2020, The Journal of physiology.

Stress activated signalling impaired protein quality control pathways in human hypertrophic cardiomyopathy.

H. Mannherz, T. Gambichler, A. Mügge, 2021, International journal of cardiology.

Historical perspective on heart function: the Frank–Starling Law

J. Velden, Vasco Sequeira, 2015, Biophysical Reviews.

Targeting mitochondria in hypertrophic cardiomyopathy.

Vasco Sequeira, A. Batzner, Christoph Maack, 2023, European heart journal.

Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness

C. D. dos Remedios, Mark McConnell, J. Tardiff, 2015, The Journal of physiology.

Mechano-energetic uncoupling in hypertrophic cardiomyopathy: Pathophysiological mechanisms and therapeutic opportunities

J. Pearson, H. Tsuchimochi, Vasco Sequeira, 2023, Journal of Molecular and Cellular Cardiology Plus.

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Vasco Sequeira, C. D. dos Remedios, J. van der Velden, 2014, American journal of physiology. Heart and circulatory physiology.

Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure–function relationships

D. Kuster, J. van der Velden, E. R. Witjas-Paalberends, 2014, Pflügers Archiv - European Journal of Physiology.

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.

Christopher N. Johnson, Jonathan P. Davis, R. Pattanayek, 2019, Cell calcium.

Chapter 4 Positive correlation between contractile dysfunction of the sarcomere and regional systolic strain in hypertrophic cardiomyopathy

A. Schinkel, M. Michels, O. Soliman, 2014 .

Editorial: Bridging Techniques: Basic Science of Molecules, Cellular Systems, and Whole-Organ Physiology

Christopher N. Johnson, J. Pearson, R. Szulcek, 2022, Frontiers in Physiology.

The Frank–Starling Law: a jigsaw of titin proportions

J. van der Velden, Vasco Sequeira, 2017, Biophysical Reviews.