David Goertsen

Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids

Nicholas C. Flytzanis, V. Gradinaru, J. Pickel, 2020, bioRxiv.

Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid

Nicholas C. Flytzanis, V. Gradinaru, N. Goeden, 2022, Molecular therapy. Methods & clinical development.

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Miguel R. Chuapoco, Nicholas C. Flytzanis, G. Feng, 2021, Nature Neuroscience.

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.

Sripriya Ravindra Kumar, Miguel R. Chuapoco, V. Gradinaru, 2022, Annual review of neuroscience.

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

Sripriya Ravindra Kumar, B. Levi, E. Lein, 2023, bioRxiv.

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Miguel R. Chuapoco, Nicholas C. Flytzanis, V. Gradinaru, 2021, Nature Neuroscience.

Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors

Sripriya Ravindra Kumar, V. Gradinaru, J. Vielmetter, 2023, Science advances.

Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier

Sripriya Ravindra Kumar, V. Gradinaru, J. Vielmetter, 2023, bioRxiv.

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

Sripriya Ravindra Kumar, B. Levi, E. Lein, 2023, Nature communications.