A. Constan

发表

Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice.

G. L. Kedderis, J. Peters, J. Everitt, 1999, Toxicology and applied pharmacology.

Long‐term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice

L. Pluta, J. Everitt, M. Templin, 1998, Environmental and molecular mutagenesis.

Patterns of chloroform-induced regenerative cell proliferation in BDF1 mice correlate with organ specificity and dose-response of tumor formation.

D. Wolf, M. Templin, B. Wong, 1998, Carcinogenesis.

Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice.

J. Everitt, B. Wong, B. Butterworth, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Assessing Risk of Drug Combinations

C. Borgert, A. Constan, 2010 .

Abstract 2156: IK-930 is a novel TEAD inhibitor for the treatment of cancers harboring mutations in the Hippo signal transduction pathway

M. Sanchez-Martin, B. Amidon, J. Ecsedy, 2022, Cancer Research.

A unique pattern of hepatocyte proliferation in F344 rats following long-term exposures to low levels of a chemical mixture of groundwater contaminants.

R. S. Yang, D. Baker, A. Constan, 1995, Carcinogenesis.

Lead. Possible toxicity in urban vs rural rats.

M. Anver, R. Hartung, A. Constan, 1975, Archives of environmental health.

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy.

I. McLay, S. Phipps, M. Belvisi, 2001, Bioorganic & medicinal chemistry.

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

Melvin E. Andersen, Harihara M. Mehendale, Raymond S. H. Yang, 1996, Archives of Toxicology.

The use of physiologically-based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures.

H A el-Masri, R. S. Thomas, R S Thomas, 1995, Toxicology letters.

The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures.

H A el-Masri, R. S. Thomas, R S Thomas, 1995, Toxicology letters.

Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.

Fiona Sewell, Sally Robinson, Beatriz Silva Lima, 2014, Regulatory toxicology and pharmacology : RTP.

Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method.

R S Yang, R. S. Thomas, R S Thomas, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway

Jeanne A. Ferguson, J. Sydor, J. Adams, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Increased Rate of Apoptosis Correlates with Hepatocellular Proliferation in Fischer-344 Rats Following Long-Term Exposure to a Mixture of Groundwater Contaminants

R. S. Yang, J. Tessari, A. Constan, 1996, Toxicologic pathology.

Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats.

H A el-Masri, A A Constan, H. Ramsdell, 1996, Toxicology and applied pharmacology.