I. Saikawa

发表

Development of β-lactams with antipseudomonal activity

Yasuo Watanabe, S. Minami, I. Saikawa, 1996, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone

S. Mitsuhashi, T. Noumi, M. Inoue, 1988, Antimicrobial Agents and Chemotherapy.

Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals

J. Katahira, Y. Watanabe, I. Saikawa, 1988, Antimicrobial Agents and Chemotherapy.

Studies on protein binding of antibiotics. IV. Effect of the binding of drug to 100,000 X g supernatant fluid of rabbit liver homogenates on urinary excretion.

Y. Watanabe, I. Saikawa, T. Hayashi, 1982, The Journal of antibiotics.

Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis

S. Mitsuhashi, M. Inoue, J. Mitsuyama, 1988, Antimicrobial Agents and Chemotherapy.

Studies on protein binding of antibiotics. V. Effect of the binding of drug to 100,000 X g supernatant fluid of human liver homogenates on urinary excretion.

Y. Watanabe, I. Saikawa, T. Hayashi, 1982, The Journal of antibiotics.

STUDIES ON PROTEIN BINDING OF ANTIBIOTICS

Toshio Hayashi, Yasuo Watanabe, R. Takada, 1980 .

Structure activity relationships in PIPC-analogues against Pseudomonas aeruginosa.

Y. Ito, J. Mitsuyama, A. Yotsuji, 1989, The Journal of antibiotics.

[Preparations and some reactions of 3-amino-5(and 6)-methyl-1,2,4-triazine].

I. Saikawa, T. Maeda, 1967, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin

S. Mitsuhashi, S. Minami, I. Saikawa, 1979, Antimicrobial Agents and Chemotherapy.

[STUDIES ON NITROFURAN AND RELATED COMPOUNDS FOR MEDICINAL PURPOSE. III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3-AMINO-1,2,4-TRIAZINE DERIVATIVES].

A. Takai, I. Saikawa, 1964, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[STUDIES ON NITROFURAN AND RELATED COMPOUNDS FOR MEDICINAL PURPOSE. I. CYCLIZATION OF 1,5-BIS(5-NITRO-2-FURYL)-1,4-PENTADIEN-3-ONE AMIDINOHYDRAZONE AND RELATED COMPOUNDS].

A. Takai, I. Saikawa, 1964, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Studies on monocyclic beta-lactam antibiotics. II. Synthesis and antibacterial activity of 3-acylamino-2-azetidinone-1-oxysulfonic acids.

I. Saikawa, C. Yoshida, T. Kitani, 1985, The Journal of antibiotics.

[Studies on beta-lactam antibiotics for medicinal purpose. VIII. Synthesis of 7-[D(-)-alpha-(4-alkyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]-cephalosporanic acids and structure-antibacterial activity (author's transl)].

H. Ochiai, I. Saikawa, H. Taki, 1979, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Induction of cephalosporinase production by various penicillins in enterobacteriaceae.

S. Mitsuhashi, Yasuo Watanabe, S. Minami, 1983, The Journal of antibiotics.

Antibacterial activity of cefoperazone alone and in combination against cephalosporinase-producing Enterobacter cloacae

S. Mitsuhashi, S. Minami, Y. Watanabe, 1983, Antimicrobial Agents and Chemotherapy.

[Studies on absorption, distribution and excretion of 14C labeled pivaloyloxymethyl (+)-(6R,7R)- 7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]- 3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (14C-T-2588) in rats and mice].

M. Onoda, I. Saikawa, T. Maeda, 1986, The Japanese journal of antibiotics.

Pharmacokinetic studies on the concomitant administration of piperacillin and cefazolin, and piperacillin and cefoperazone in rabbits.

K. Totsuka, Y. Watanabe, I. Saikawa, 1986, The Journal of antibiotics.

[Pyridonecarboxylic acids as antibacterial agents. V. Synthesis and structure-activity relationship of 7-amino-6-fluoro-1-(fluorophenyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids].

H. Narita, Y. Konishi, A. Yotsuji, 1986, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

In vitro and in vivo antibacterial activity of T-1982, a new semisynthetic cephamycin antibiotic

S. Mitsuhashi, M. Takahata, A. Yotsuji, 1982, Antimicrobial Agents and Chemotherapy.

[STUDIES ON NITROFURAN AND RELATED COMPOUNDS FOR MEDICINAL PURPOSE. II. HYDROLYSIS OF 1,5-BIS(5-NITRO-2-FURYL)-1,4-PENTADIEN-3-ONE AMIDINOHYDRAZONE AND ITS CYCLIZED PRODUCT].

A. Takai, I. Saikawa, 1964, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[Studies on beta-lactam antibiotics for medicinal purpose. VI. Studies on the metabolism of 6-[D(--)-alpha-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-phenylacetamido]penicillanic acid (T-1220) (author's transl)].

A. Takai, I. Saikawa, C. Yoshida, 1977, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

In Vitro and In Vivo Antibacterial Activity of T-1220, a New Semisynthetic Penicillin

S. Mitsuhashi, Y. Watanabe, I. Saikawa, 1977, Antimicrobial Agents and Chemotherapy.

InVitro Antibacterial Activity ofCefoperazone (T-1551), a NewSemisynthetic Cephalosporin

S. Mitsuhashi, S. Minami, I. Saikawa, 1979 .

[Pyridonecarboxylic acids as antibacterial agents. IV. Synthesis and structure-activity relationship of 7-amino-1-aryl-6-fluoro-4-quinolone-3-carboxylic acids].

Y. Kobayashi, H. Narita, Y. Konishi, 1986, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Protective effect of piperacillin against the nephrotoxicity of cisplatin in rats

J. Katahira, T. Muratani, Y. Watanabe, 1989, Antimicrobial Agents and Chemotherapy.

Studies on β-Lactam Antibiotics for Medicinal Purpose. Part 17. Synthesis and Structure-Activity Relationships of 7β-[D(-)-α-Amino-α-(4-hydroxyphenyl)acetamido]-3-substituted Methyl-3-cephem-4-carboxylic Acids.

Yasuo Watanabe, S. Minami, I. Saikawa, 1986 .

Studies on β-Lactam Antibiotics for Medicinal Purpose. Part 18. Synthesis and Structure-Activity Relationships of 7β-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-substituted Methyl-3-cephem-4-carboxylic Acid Derivatives.

Yasuo Watanabe, S. Minami, I. Saikawa, 1986 .

Immunological properties of a novel beta-lactamase produced by Bacteroides fragilis.

S. Mitsuhashi, A. Takai, M. Inoue, 1984, The Journal of antibiotics.

Reduction of cephamycin concentrations at the infection site in mice with experimental peritoneal infection caused by cephalosporinase-producing bacteria

S. Mitsuhashi, A. Takai, S. Minami, 1986, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo antibacterial activity of cefoperazone.

S. Mitsuhashi, S. Minami, A. Yotsuji, 1980, Clinical therapeutics.

Studies on protein binding of antibiotics. II. Effect of apalcillin on protein binding and pharmacokinetics of cefoperazone and cefazolin.

Y. Watanabe, I. Saikawa, T. Hayashi, 1981, The Journal of antibiotics.

Studies on protein binding of antibiotics. I. Effect of cefazolin on protein binding and pharmacokinetics of cefoperazone.

R. Takada, Y. Watanabe, I. Saikawa, 1980, The Journal of antibiotics.

Interactions of beta-lactam antibiotics and antineoplastic agents

I. Saikawa, Y. Yamashiro, H. Taki, 1983, Antimicrobial Agents and Chemotherapy.

Interactions of ,-Lactam Antibiotics and Antineoplastic Agents

Yasushi, I. Saikawa, Y. Yamashiro, 2022 .

INACTIVATION OF CEPHAMYCINS BY VARIOUS β-LACTAMASES FROM GRAM-NEGATIVE BACTERIA

S. Mitsuhashi, Yasuo Watanabe, S. Minami, 1984 .

Cephamycin inactivation due to enzymatic hydrolysis by beta-lactamase from Bacteroides fragilis

S. Mitsuhashi, A. Takai, M. Inoue, 1985, Antimicrobial Agents and Chemotherapy.

Studies on protein binding of antibiotics. III. Effect of novobiocin on protein binding and pharmacokinetics of cefoperazone and cefazolin.

Y. Watanabe, I. Saikawa, T. Hayashi, 1981, The Journal of antibiotics.

In Vitro and in Vivo Antibacterial Activity of T-1551, a new Semisynthetic Cephalosporin

S. Mitsuhashi, S. Minami, I. Saikawa, 1980 .

InVitro andInVivoAntibacterial Activity ofT-1220, aNew Semisynthetic Penicillin

Yasuo Watanabe, I. Saikawa, T. Hayashi, 1977 .

Outer membrane permeation of Bacteroides fragilis by cephalosporins

S. Mitsuhashi, M. Inoue, J. Mitsuyama, 1988, Antimicrobial Agents and Chemotherapy.

Enhancement of 5-fluorouracil uptake into the bacterial cell by piperacillin.

M. Takahata, A. Yotsuji, I. Saikawa, 1986, The Journal of antibiotics.

Pyridonecarboxylic acids as antibacterial agents. VI. Synthesis and structure-activity relationship of 7-(alkyl, cycloalkyl, and vinyl)-1-cyclopropyl-6-fluoro-4-quinolone-3-carboxylic acids.

H. Narita, K. Tanaka, Y. Todo, 1994, Chemical & pharmaceutical bulletin.