C. Howles

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Assessment of the role of serum luteinizing hormone and estradiol response to follicle-stimulating hormone on in vitro fertilization treatment outcome.

E. Loumaye, L. O’Dea, P. Engrand, 1997, Fertility and sterility.

Drugs used for ovarian stimulation: Clomiphene citrate, aromatase inhibitors, metformin, gonadotropins, gonadotropin-releasing hormone analogs, and recombinant gonadotropins

Z. Shoham, C. Howles, 2017 .

Management of male hypogonadotrophic hypogonadism.

T. Matsuda, Toshiaki Tanaka, C. Howles, 2007, Endocrine journal.

Infertility therapy-associated multiple pregnancies (births): an ongoing epidemic.

R. Frydman, R. Berkowitz, Z. Rosenwaks, 2003, Reproductive biomedicine online.

The antral follicle count: practical recommendations for better standardization.

F. Broekmans, D. de Ziegler, G. Trew, 2010, Fertility and sterility.

Advances in ART Pharmacology: Drug Delivery Systems and the Pipeline

C. Howles, 2020 .

Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Short-term luteinizing hormone-releasing hormone agonist treatment: prospective trial of a novel ovarian stimulation regimen for in vitro fertilization.

R. Edwards, K. Elder, C. Howles, 1989, Fertility and sterility.

Textbook of assisted reproductive technologies : laboratory and clinical perspectives

Z. Shoham, D. Gardner, A. Weissman, 2008 .

A double-blind, randomized study to compare recombinant human follicle stimulating hormone (FSH; Gonal-F®) with highly purified urinary FSH (Metrodin® HP) in women undergoing assisted reproductive techniques including intracytoplasmic sperm injection

R. Frydman, F. Truong, C. Howles, 2000 .

Recombinant human follicle stimulating hormone (r-hFSH; Gonal-F) versus highly purified urinary FSH (Metrodin HP): results of a randomized comparative study in women undergoing assisted reproductive techniques.

L. Nilsson, L. Hamberger, M. Wikland, 1997, Human reproduction.

Improving the consistency of ovarian stimulation: follitropin alfa filled-by-mass.

M. Wikland, C. Howles, J. hugues, 2006, Reproductive biomedicine online.

Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory process.

S. Chappel, C. Howles, 1991, Human reproduction.

Role of LH and FSH in ovarian function

C. Howles, 2000, Molecular and Cellular Endocrinology.

A multi-centre international study of salivary hormone oestradiol and progesterone measurements in ART monitoring.

S. Granger, L. Atkinson, E. Bosch, 2020, Reproductive biomedicine online.

Biological versus chronological ovarian age: implications for assisted reproductive technology

P. Humaidan, S. Hillier, C. Alviggi, 2009, Reproductive biology and endocrinology : RB&E.

V. Alam, D. Tredway, R. Homburg, 2010, Reproductive biomedicine online.

Low-dose FSH therapy for anovulatory infertility associated with polycystic ovary syndrome: rationale, results, reflections and refinements.

R. Homburg, C. Howles, 1999, Human reproduction update.

Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study.

M. Wikland, M. Germond, G. Trew, 2009, Reproductive biomedicine online.

Anti-Müllerian hormone versus antral follicle count for defining the starting dose of FSH.

P. Wong, V. Lan, C. Howles, 2013, Reproductive biomedicine online.

Recombinant follicle stimulating hormone: development of the first biotechnology product for the treatment of infertility. Recombinant Human FSH Product Development Group.

R. Campbell, A. Munafo, P. Lepage, 1998, Human reproduction update.

Genetic engineering of human FSH (Gonal-F).

C. Howles, 1996, Human reproduction update.

The Gonadotropins in IVF

C. Howles, 2019, How to Prepare the Egg and Embryo to Maximize IVF Success.

Progesterone supplementation during cryopreserved embryo transfer cycles: efficacy and convenience of two vaginal formulations.

V. Lan, P. Tuan, C. Howles, 2008, Reproductive biomedicine online.

Functionality of a novel follitropin alfa pen injector: results from human factor interactions by patients and nurses

C. Howles, P. Arriagada, H. Saunders, 2018, Expert opinion on drug delivery.

A prospective, randomized comparison of two starting doses of recombinant FSH in combination with cetrorelix in women undergoing ovarian stimulation for IVF/ICSI.

A. Knutsson, L. Nilsson, M. Wikland, 2001, Human reproduction.

Bleeding, severe pelvic infection, and ectopic pregnancy

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Treatment strategies in assisted reproduction for the poor responder patient

A. Weissman, C. Howles, 2012 .

Treatment strategies in assisted reproduction for women of advanced maternal age.

Chung-Hoon Kim, K. Elder, C. Howles, 2006, International surgery.

Human Recombinant Follicle Stimulating Hormone (Follitropin‐α)

J. Tresguerres, C. Howles, J. A. Peinado, 2000 .

Successful in-vitro fertilisation and embryo transfer after treatment with recombinant human FSH

P. Devroey, A. Steirteghem, M. Germond, 1992, The Lancet.

Clinical assessment of recombinant human follicle-stimulating hormone in stimulating ovarian follicular development before in vitro fertilization. Recombinant Human FSH Study Group.

R. Frydman, D. Barlow, C. Howles, 1998, Fertility and sterility.

Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.

H. Delemarre-van de Waal, P. Devroey, M. Bonduelle, 2014, Reproductive biomedicine online.

Conventional ovarian stimulation no longer exists: welcome to the age of individualized ovarian stimulation.

F. Ubaldi, L. Nardo, S. Nelson, 2011, Reproductive biomedicine online.

Short term use of an LHRH agonist to treat poor responders entering an in-vitro fertilization programme.

R. Edwards, C. Howles, M. Macnamee, 1987, Human reproduction.

The effect of transdermal testosterone gel pretreatment on controlled ovarian stimulation and IVF outcome in low responders.

Chung-Hoon Kim, C. Howles, H. Lee, 2011, Fertility and sterility.

The place of gonadotrophin-releasing hormone antagonists in reproductive medicine.

C. Howles, 2002, Reproductive biomedicine online.

Multiple follicular development and ovarian steroidogenesis following subcutaneous administration of a highly purified urinary FSH preparation in pituitary desensitized women undergoing IVF: a multicentre European phase III study.

E. Loumaye, C. Howles, G. Luyet, 1994, Human reproduction.

A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin.

C. Howles, H. Okada, G. Decosterd, 2009, Fertility and sterility.

Comparative pharmacokinetics of two urinary human follicle stimulating hormone preparations in healthy female and male volunteers.

C. Howles, H. Porchet, J. L. le Cotonnec, 1993, Human reproduction.

Assessment of the role of serum luteinizing hormone and estradiol response to follicle-stimulating hormone on in vitro fertilization treatment outcome

E. Loumaye, L. O’Dea, P. Engrand, 1997 .

Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation.

S. Hillier, L. Westergaard, R. Fleming, 2007, Human reproduction.

EFFECT OF HIGH TONIC LEVELS OF LUTEINISING HORMONE ON OUTCOME OF IN-VITRO FERTILISATION

R. Edwards, C. Howles, M. Macnamee, 1986, The Lancet.

Cost-effectiveness modelling of recombinant FSH versus urinary FSH in assisted reproduction techniques in the UK.

W. Ledger, M. Wikland, S. Daya, 2001, Human reproduction.

Inducing follicular development in anovulatory patients and normally ovulating women: current concepts and the role of recombinant gonadotropins

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Clinical assessment of human gonadotrophins produced by recombinant DNA technology.

E. Loumaye, L. O’Dea, I. Martineau, 1996, Human reproduction.

Ovarian stimulation protocols in assisted reproductive technology: an update

D. Ezcurra, R. Homburg, C. Howles, 2012, Expert review of endocrinology & metabolism.

Safety of Ovaleap® (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study

R. Levy-Toledano, S. Kaplan, A. Lass, 2021, Frontiers in Endocrinology.

Textbook of assisted reproductive techniques

Z. Shoham, D. Gardner, A. Weissman, 2012 .

Evaluation of Sperm

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Contemporary genetic technologies and female reproduction

C. Simón, M. Matzuk, P. Devroey, 2011, Human reproduction update.

The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy

D. Wells, S. Munné, C. Howles, 2009, Current opinion in obstetrics & gynecology.

Randomized, controlled, open-label, non-inferiority study of the CONSORT algorithm for individualized dosing of follitropin alfa.

F. Broekmans, G. Trew, A. Borini, 2015, Reproductive biomedicine online.

Ovarian thecal/interstitial androgen synthesis is enhanced by a follicle-stimulating hormone-stimulated paracrine mechanism.

S. Hillier, C. Howles, P. Whitelaw, 1993, Endocrinology.

How to Improve your ART Success Rates: Luteinizing hormone supplementation in ART

C. Howles, 2011 .

Gonadotrophin control of follicular function.

S. Hillier, C. Howles, P. Whitelaw, 1995, Hormone research.

Randomized trial comparing luteinizing hormone supplementation timing strategies in older women undergoing ovarian stimulation.

H. Behre, S. Longobardi, C. Howles, 2015, Reproductive biomedicine online.

Cell-specific expression of aromatase and LH receptor mRNAs in rat ovary.

S. Hillier, C. Howles, P. Whitelaw, 1992, Journal of molecular endocrinology.

Effect of luteinizing hormone on follicle stimulating hormone-activated paracrine signalling in rat ovary.

S. Hillier, C. Howles, C. Smyth, 1995, Human reproduction.

The use of a decremental dose regimen in patients treated with a chronic low-dose step-up protocol for WHO Group II anovulation: a prospective randomized multicentre study.

C. Nappi, E. Porcu, V. de Leo, 2006, Human reproduction.

Evidence that opioid peptides and dopamine participate in the suckling-induced release of prolactin in the ewe.

P. G. Knight, C. Howles, F. J. Cunningham, 1986, Neuroendocrinology.

Pregnancies after IVF when high tonic LH is reduced by long-term treatment with GnRH agonists.

R. Edwards, C. Howles, M. Macnamee, 1987, Human reproduction.

Textbook of Assisted Reproductive Techniques : Volume 2: Clinical Perspectives

Z. Shoham, D. Gardner, A. Weissman, 2012 .

Textbook of Assisted Reproductive Techniques : Volume 1: Laboratory Perspectives

Colin M. Howles, Zeev Shoham, David K. Gardner, 2012 .

Follicular development and early luteal function of conception and non-conceptional cycles after human in-vitro fertilization: endocrine correlates.

R. Edwards, C. Howles, M. Macnamee, 1987, Human reproduction.

Does growth hormone-releasing factor assist follicular development in poor responder patients undergoing ovarian stimulation for in-vitro fertilization?

T. Strowitzki, M. Germond, E. Loumaye, 1999, Human Reproduction.

The use of GnRH agonists

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Setting Up and ART Laboratory

Ariel Weissman, Colin M. Howles, Zeev Shoham, 2001 .

Cytoplasmic fragmentation in human embryos in vitro: implications and the relevance of fragment removal

Z. Shoham, D. Gardner, A. Weissman, 2001 .

The effect of progesterone supplementation prior to the induction of ovulation in women treated for in-vitro fertilization.

R. Edwards, C. Howles, M. Macnamee, 1987, Human reproduction.

No influence of body weight on pregnancy rate in patients treated with cetrorelix according to the single- and multiple-dose protocols.

K. Junge, J. Engel, K. Diedrich, 2003, Reproductive biomedicine online.

Gamete intrafallopian transfer (GIFT)

Z. Shoham, D. Gardner, A. Weissman, 2001 .

The Endocrinology of Stimulated Cycles and Influence on Outcome

C. Howles, M. Macnamee, 1990 .

Zygote intrafallopian transfer (ZIFT)

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Safety and efficacy of a 3 mg dose of the GnRH antagonist cetrorelix in preventing premature LH surges: report of two large multicentre, multinational, phase IIIb clinical experiences.

K. Diedrich, R. Felberbaum, F. Olivennes, 2003, Reproductive biomedicine online.

Progesterone supplementation in the late follicular phase of an in-vitro fertilization cycle: a 'natural' way to time oocyte recovery?

R. Edwards, C. Howles, M. Macnamee, 1988, Human reproduction.

Introduction: The Beginnings of Human in Vitro Fertilization

Z. Shoham, D. Gardner, A. Weissman, 2001 .

A double-blind, randomized study to compare recombinant human follicle stimulating hormone (FSH; Gonal-F) with highly purified urinary FSH (Metrodin) HP) in women undergoing assisted reproductive techniques including intracytoplasmic sperm injection. The French Multicentre Trialists.

R. Frydman, F. Truong, C. Howles, 2000, Human reproduction.

The influence of stimulation regimes and luteal phase support on the outcome of IVF.

R. Edwards, C. Howles, M. Macnamee, 1988, Human reproduction.

A comparative prospective study of a chronic low dose versus a conventional ovulation stimulation regimen using recombinant human follicle stimulating hormone in anovulatory infertile women.

B. Hédon, F. Truong, C. Howles, 1998, Human reproduction.

Clinical Endocrinology of Reproduction

S. Yen, R. Yalow, R. Edwards, 1990 .

Recombinant human follicle-stimulating hormone treatment leads to normal follicular growth, estradiol secretion, and pregnancy in a World Health Organization group II anovulatory woman.

E. Loumaye, C. Howles, P. Hornnes, 1993, Fertility and sterility.

Do raised serum luteinizing hormone levels during stimulation for in-vitro fertilization predict outcome?

C. Howles, 1990, British journal of obstetrics and gynaecology.

Cryopreservation and storage of sperm

Z. Shoham, D. Gardner, A. Weissman, 2001 .

Effects of passive immunization against oestradiol-17 beta on some endocrine values of the male lamb.

G. Waites, B. A. Morris, N. Jenkins, 1986, Journal of Reproduction and Fertility.

Female infertility therapy : current practice

Z. Shoham, H. Jacobs, C. Howles, 1999 .

Predictive factors and a corresponding treatment algorithm for controlled ovarian stimulation in patients treated with recombinant human follicle stimulating hormone (follitropin alfa) during assisted reproduction technology (ART) procedures. An analysis of 1378 patients

V. Alam, P. Engrand, C. Howles, 2006, Current medical research and opinion.

RANDOMIZED CONTROLLED TRIALS DO NOT ALWAYS FIT THE PURPOSE: A SCIENCE-BASED RESPONSE TO VENETIS AND MOL'S EDITORIAL ON BIOSIMILARS OF FOLLITROPIN ALFA.

F. de Mora, C. Howles, 2023, Drug discovery today.

Induction of follicular growth and production of a normal hormonal milieu in spite of using a constant low dose of luteinizing hormone in women with hypogonadotrophic hypogonadism.

Z. Shoham, Y. Zalel, V. Insler, 1994, Human Reproduction.

Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.

P. Devroey, M. Bonduelle, J. Geraedts, 2014, Reproductive biomedicine online.

Reproductive Biology and Endocrinology Open Access Biological versus Chronological Ovarian Age: Implications for Assisted Reproductive Technology

P. Humaidan, S. Hillier, C. Alviggi, 2022 .

P-211. A comparative prospective study of a chronic low-dose versus a conventional ovulation stimulation regimen using recombinant human FSH (Gonal-F®) in WHO group II anovulatory infertile women

B. Hédon, F. Truong, C. Howles, 1997 .

Recombinant human follicle-stimulating hormone treatment leads to normal follicular growth, estradiol secretion, and pregnancy in a World Health Organization group II anovulatory woman.

E. Loumaye, C. Howles, P. Hornnes, 1993, Fertility and sterility.

New approaches to ovarian stimulation. Discussion

R. Fanchin, Jacques Cohen, H. Jones, 1998 .

Endocrine monitoring for assisted human conception.

C. Howles, M. Macnamee, 1990, British medical bulletin.