E. Bigham

发表

Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis.

J. E. Kelsey, E. Bigham, C. Gragg, 1984, Journal of Medicinal Chemistry.

Synthesis and use of 3-deoxy-D-manno-2-octulosonate (KDO) in Escherichia coli: potential sites of inhibition

T. A. Miller, J. E. Kelsey, E. Bigham, 1983 .

Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor.

A. Goetz, A. Peat, D. M. Hickey, 2007, Bioorganic & medicinal chemistry letters.

In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues.

R. Ferone, R. Mullin, B. Keith, 1992, Biochemical pharmacology.

New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.

M. Edelstein, E. Bigham, G. K. Smith, 1992, The Journal of biological chemistry.

Synthesis of ultra-short-acting neuromuscular blocker GW 0430: a remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates.

J. A. Ray, R. Mook, V. Samano, 1999, Organic letters.

Thallium in organic synthesis. 45. Synthesis of aromatic fluorides

A. Mckillop, E. Bigham, E. Taylor, 1977 .

2-(Anilinomethyl)imidazolines as α1-adrenoceptor agonists: the identification of α1A subtype selective 2′-carboxylic acid esters and amides

M. J. Bishop, J. Speake, D. Minick, 2001 .

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.

M. J. Bishop, A. Goetz, F. Tavares, 2006, Bioorganic & medicinal chemistry letters.

Thallium in organic synthesis. XXXII. Oxidative rearrangement of olefins using thallium(III) nitrate (TTN)

A. Mckillop, J. D. Hunt, E. Bigham, 1973 .

2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.

M. J. Bishop, D. Drewry, J. Speake, 2002, Bioorganic & medicinal chemistry letters.

α1-Adrenoceptor Agonists: The Identification of Novel α1A Subtype Selective 2′-Heteroaryl-2-(phenoxymethyl)imidazolines

M. J. Bishop, J. Speake, J. Berman, 2002 .

2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.

T. Blumenkopf, T. Spector, C. Koble, 1992, Journal of medicinal chemistry.

2-(Anilinomethyl)imidazolines as α1 adrenergic receptor agonists: α1a subtype selective 2′-heteroaryl compounds

M. J. Bishop, J. Speake, E. Bigham, 2003 .

Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.

R. Ferone, E. Bigham, G. K. Smith, 1994, Journal of medicinal chemistry.

Thienyl and Thiazolyl Acyclic Analogues of 5‐Deazatetrahydrofolic Acid.

Gary K. Smith, E. Bigham, D. Duch, 1994 .

Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.

R. Ferone, E. Bigham, W. Mallory, 1992, Journal of medicinal chemistry.

Multisubstrate Analogue Inhibitors of Glycinamide Ribonucleotide Transformylase Based on 5-Deazaacyclo Tetrahudrofolate (5-DACTHF)

R. Ferone, Gary K. Smith, E. Bigham, 1993 .

Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis.

J. E. Kelsey, E. Bigham, C. Gragg, 1984, Journal of medicinal chemistry.

Potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1.

M. J. Bishop, A. Goetz, F. Tavares, 2006, Journal of medicinal chemistry.

Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines.

M. J. Bishop, J. Speake, E. Bigham, 2002, Bioorganic & medicinal chemistry letters.

Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.

Sanjay S. Patel, J. A. Ray, R. Mook, 2003, Journal of medicinal chemistry.

Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers.

J. A. Ray, R. Mook, V. Samano, 1999, Journal of medicinal chemistry.

On the substrate specificity of bovine liver dihydrofolate reductase: new unconjugated dihydropterin substrates.

E. Bigham, G. K. Smith, C. A. Nichol, 1987, Archives of biochemistry and biophysics.