Kenneth Offit

发表

Abstract LB-383: Towards automation of germline variant curation in cancer genetics

Vijai Joseph, Vignesh Ravichandran, Zarina Shameer, 2018 .

Development of Clinical Domain Working Groups for the Clinical Genome Resource (ClinGen): Lessons Learned and Plans for the Future

Heidi L. Rehm, Danielle R. Azzariti, Erin M. Ramos, 2018, Genetics in Medicine.

Collaborative science in the next-generation sequencing era: a viewpoint on how to combine exome sequencing data across sites to identify novel disease susceptibility genes

Steven N. Hart, Robert J. Klein, Vignesh Ravichandran, 2016, Briefings Bioinform..

Germline PALB2 mutation analysis in breast–pancreas cancer families

Kenneth Offit, Marc Tischkowitz, Robert Kurtz, 2011, Journal of Medical Genetics.

ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes

Kenneth Offit, David G. Mutch, Stephen Gruber, 2006, Annals of Surgical Oncology.

Translating genomics in cancer care.

Kenneth Offit, Yvonne Bombard, Peter B Bach, 2013, Journal of the National Comprehensive Cancer Network : JNCCN.

Systematic immunohistochemistry screening for Lynch syndrome in early age-of-onset colorectal cancer patients undergoing surgical resection.

Kenneth Offit, Jinru Shia, K. Offit, 2012, Journal of the American College of Surgeons.

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Paolo Vineis, Peter Kraft, Lucia Miligi, 2015, Nature Communications.

The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk

Steven N. Hart, Chunling Hu, Mark E. Robson, 2017, npj Breast Cancer.

Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation

Mark E. Robson, Kenneth Offit, Jaya M. Satagopan, 2002 .

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

Kenneth Offit, Diether Lambrechts, Gil Atzmon, 2014, Nature Communications.

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Michael Jones, Peter Kraft, Arnaud Droit, 2017, Nature Genetics.

Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk.

Junjian Liu, Kenneth Offit, Virginia G Kaklamani, 2005, Cancer research.

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Rohini Rau-Murthy, Jinghui Zhang, Kenneth Offit, 2013, Nature Genetics.

Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers.

Christiana Kartsonaki, Mads Thomassen, Etienne Rouleau, 2011, Human molecular genetics.

Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.

Paolo Vineis, Theodore R Holford, Peter Kraft, 2016, Human molecular genetics.

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

Mads Thomassen, Nina Ditsch, Vijai Joseph, 2012, Breast Cancer Research.

Novel pedigree analysis implicates DNA repair and chromatin remodeling in Multiple Myeloma risk

Alun Thomas, Nicola J. Camp, Vijai Joseph, 2017 .

Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers.

Mads Thomassen, Nina Ditsch, Dieter Niederacher, 2009, Human molecular genetics.

Towards Automation of Germline Variant Curation in Clinical Cancer Genetics

Zarina Shameer, Kenneth Offit, Mark Robson, 2018, Genetics in Medicine.

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.

Harvey Risch, Yian A Chen, Mads Thomassen, 2018, Cancer research.

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Wei Lu, Wei Zheng, Mads Thomassen, 2013, Nature Genetics.

Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015.

Kenneth Offit, Elizabeth Swisher, Seema Khan, 2016, Journal of the National Comprehensive Cancer Network : JNCCN.

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.

Dong Liang, Patrick Neven, Harvey Risch, 2016, Journal of the National Cancer Institute.

Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

Mads Thomassen, Julian Peto, Peter A. Fasching, 2013, PLoS genetics.

Genetic Analysis of the Early Natural History of Epithelial Ovarian Carcinoma

Adam B. Olshen, Mark E. Robson, Kenneth Offit, 2010, PloS one.

Oncologic therapy shapes the fitness landscape of clonal hematopoiesis

Ahmet Zehir, Stuart Gardos, Nilanjan Chatterjee, 2019, bioRxiv.

Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk.

Nengjun Yi, Kui Zhang, Kenneth Offit, 2011, Metabolism: clinical and experimental.

Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Paolo Vineis, Peter Kraft, Bin Zhu, 2018, Nature Communications.

Blood Biomarker Levels to Aid Discovery of Cancer-Related Single-Nucleotide Polymorphisms: Kallikreins and Prostate Cancer

Andrew J. Vickers, Pär Stattin, Fredrik Wiklund, 2010, Cancer Prevention Research.

Breast cancer risk variants at 6 q 25 display different phenotype associations and regulate ESR 1 , RMND 1 and CCDC 170

Wei Zheng, Mads Thomassen, Nicholas A. Sinnott-Armstrong, 2016 .

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Jian Su, Wen Tan, Paolo Vineis, 2015, Journal of the National Cancer Institute.

Genome-wide association study identifies multiple susceptibility loci for diffuse large B-cell lymphoma

Paolo Vineis, Theodore R Holford, Peter Kraft, 2014, Nature Genetics.

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

Kenneth Offit, Tom Walsh, T. Walsh, 2005, Human molecular genetics.

Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

Patrick Neven, Hui Zhao, Nazneen Rahman, 2012, PloS one.

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Christiana Kartsonaki, Mads Thomassen, Julian Peto, 2010, Nature Genetics.

COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration

Peter Kraft, Mads Thomassen, Daniel J. Park, 2013, Breast Cancer Research.

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Olufunmilayo I. Olopade, Mads Thomassen, Torben A. Kruse, 2014, PLoS genetics.

Risk of ovarian cancer in BRCA1 and BRCA2 mutation-negative hereditary breast cancer families.

Nandita Mitra, Kenneth Offit, Tessa Cigler, 2005, Journal of the National Cancer Institute.

Correction: Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

Joshua M. Korn, Christiana Kartsonaki, Amanda B. Spurdle, 2010, PLoS Genetics.

The signatures of autozygosity among patients with colorectal cancer.

Jurg Ott, Kenneth Offit, Francis Barany, 2008, Cancer research.

Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping

Eleazar Eskin, Kenneth Offit, Kirk E Lohmueller, 2008, BMC Genetics.

Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention

Kenneth Offit, Fergus J. Couch, F. Couch, 2014, Science.

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

Mads Thomassen, Nina Ditsch, Muhammad Usman Rashid, 2015, JAMA.

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Paolo Vineis, Theodore R Holford, Peter Kraft, 2016, Nature Communications.

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

Ahmet Zehir, Levi Garraway, Colin C Pritchard, 2016, The New England journal of medicine.

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.

Ahmet Zehir, Kenneth Offit, Barry S Taylor, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing

Ahmet Zehir, Donavan T. Cheng, Kenneth Offit, 2017, BMC Medical Genomics.

The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%

Kenneth Offit, Jeffery P. Struewing, Lawrence C. Brody, 1996, Nature Genetics.

Recommendations from the EGAPP Working Group: does genomic profiling to assess type 2 diabetes risk improve health outcomes?

Jonathan S. Berg, Kenneth Offit, Benjamin Djulbegovic, 2013, Genetics in Medicine.

Decision-Making About Genetic Testing Among Women at Familial Risk for Breast Cancer

Kenneth Offit, K. Offit, H. Valdimarsdottir, 1997, Psychosomatic medicine.

Genome-wide Association Study Identiﬁes Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

Jian Gu, Paolo Vineis, Theodore R Holford, 2022 .

Discovery of common and rare genetic risk variants for colorectal cancer

Mathieu Lemire, Steven Gallinger, Michael Wainberg, 2018, Nature Genetics.

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Paolo Vineis, Peter Kraft, Lucia Miligi, 2017, Nature Communications.

Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction.

Mads Thomassen, Etienne Rouleau, Dieter Niederacher, 2010, Cancer research.

Counselling framework for moderate-penetrance cancer-susceptibility mutations

Mark E. Robson, Susan M. Domchek, Kenneth Offit, 2016, Nature Reviews Clinical Oncology.

Improved survival for BRCA2‐associated serous ovarian cancer compared with both BRCA‐negative and BRCA1‐associated serous ovarian cancer

Alexia Iasonos, Kenneth Offit, Qin Zhou, 2012, Cancer.

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

Päivi Heikkilä, Mads Thomassen, Stephen Fox, 2011, Cancer Epidemiology, Biomarkers & Prevention.

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Mads Thomassen, Stephen Fox, Dieter Niederacher, 2011, Breast Cancer Research.

Germline SDHA mutations in children and adults with cancer

Ed Reznik, Alex Kentsis, Kenneth Offit, 2018, Cold Spring Harbor molecular case studies.

Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

Marc Vidal, Dieter Niederacher, Roderic Guigó, 2011, PLoS biology.

Genome-wide Association Study Identifies Multiple Risk Loci for Chronic Lymphocytic Leukemia

Paolo Vineis, Theodore R Holford, Peter Kraft, 2013, Nature Genetics.

Genome-wide association studies of cancer.

Kenneth Offit, Peter R. Thom, Bert Gold, 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2

Gunnar Rätsch, Brian Craft, David Haussler, 2018, PLoS genetics.

Modeling genetic risk of breast cancer.

Kenneth Offit, K. Offit, N. Kauff, 2007, JAMA.

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women

Olufunmilayo I. Olopade, Mads Thomassen, Dieter Niederacher, 2016, Breast Cancer Research.

Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

Patrick Neven, Daniel F. Schmidt, Julian Peto, 2013, PLoS genetics.

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.

Michael Jones, Julian Peto, Thomas Brüning, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Alison P. Klein, William Wheeler, Li Jin, 2015 .

Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing

Vijai Joseph, Mark E. Robson, Susan M. Domchek, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Genetics, genomics, and cancer risk assessment

Julie O. Culver, Kenneth Offit, K. Offit, 2011, CA: a cancer journal for clinicians.

Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia.

Kenneth Offit, Mark Robson, Larry Norton, 2003, Journal of the National Cancer Institute.

Cancer Susceptibility Mutations in Patients With Urothelial Malignancies.

Kenneth Offit, Barry S Taylor, Vignesh Ravichandran, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer

Kenneth Offit, Larry Norton, Heather Hampel, 1996, Nature Genetics.

Personalized medicine: new genomics, old lessons

Kenneth Offit, K. Offit, 2011, Human Genetics.

A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms

Kenneth Offit, Benjamin L Ebert, Guillermo Garcia-Manero, 2009, Nature Genetics.

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.

Stefania Tommasi, Laura Cortesi, Mads Thomassen, 2019, Cancer research.