Julia Ness

发表

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.

S. Weggen, B. Bulic, Andreas Rennhack, 2012, Bioorganic & medicinal chemistry.

Presenilin‐1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ‐secretase modulators regardless of their potency and structure

S. Weggen, C. Korth, B. Bulic, 2011, Journal of neurochemistry.

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.

Oliver Werz, Karlheinz Baumann, Ramona Steri, 2010, Journal of medicinal chemistry.

SAR studies of acidic dual γ-secretase/PPARγ modulators.

O. Werz, M. Schubert-Zsilavecz, S. Weggen, 2011, Bioorganic & medicinal chemistry.

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein

J. Wiltfang, S. Weggen, J. Maler, 2008, Neurodegenerative Diseases.

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

S. Weggen, B. Bulic, Andreas Rennhack, 2012, PloS one.

Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer’s Disease

S. Weggen, B. Bulic, Andreas Rennhack, 2011, Current neuropharmacology.

Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization

B. Reif, G. Multhaup, S. Weggen, 2010, Proceedings of the National Academy of Sciences.

Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.

Gisbert Schneider, Karlheinz Baumann, Volker Hähnke, 2012, ACS chemical biology.

Identification of novel-type γ-secretase modulators by text-based virtual screening

G. Schneider, Volker Hähnke, S. Weggen, 2012 .

SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.

O. Werz, M. Schubert-Zsilavecz, Isabella Ogorek, 2015, Bioorganic & medicinal chemistry letters.