Sandra Baches

发表

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.

S. Weggen, B. Bulic, Andreas Rennhack, 2012, Bioorganic & medicinal chemistry.

Presenilin‐1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ‐secretase modulators regardless of their potency and structure

S. Weggen, C. Korth, B. Bulic, 2011, Journal of neurochemistry.

Formation of Pmel17 Amyloid Is Regulated by Juxtamembrane Metalloproteinase Cleavage, and the Resulting C-terminal Fragment Is a Substrate for γ-Secretase*

S. Weggen, E. Koo, M. Kummer, 2009, Journal of Biological Chemistry.

Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease.

T. Bayer, O. Wirths, S. Weggen, 2015, Journal of Alzheimer's disease : JAD.

EARLY LIFE STRESS ACCELERATES AMYLOID PATHOLOGY AND COGNITIVE DECLINE IN APPSWE/PS1DE9 MICE, BUT CAN BE RESCUED BY BRIEFLY BLOCKING GLUCOCORTICOID RECEPTORS AT MIDDLE AGE

S. Weggen, P. Lucassen, H. Krugers, 2017, Alzheimer's & Dementia.

Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.

T. Bayer, R. Vandenbroucke, S. Weggen, 2015, The Journal of clinical investigation.

Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease.

T. Bayer, O. Wirths, S. Weggen, 2015, Journal of Alzheimer's disease : JAD.

Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice

S. Weggen, P. Lucassen, H. Krugers, 2018, Translational Psychiatry.

Endothelial LRP 1 transports amyloid-β 1 – 42 across the blood-brain barrier

T. Bayer, R. Vandenbroucke, S. Weggen, 2015 .

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

S. Weggen, B. Bulic, Andreas Rennhack, 2012, PloS one.

Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood–brain barrier model

S. Ropele, R. Schmidt, S. Weggen, 2013, Alzheimer's Research & Therapy.

Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease.

T. Bayer, O. Wirths, S. Weggen, 2015, Journal of Alzheimer's disease : JAD.

Endothelial LRP 1 transports amyloid-β 1 – 42 across the blood-brain barrier

T. Bayer, R. Vandenbroucke, S. Weggen, 2015 .