Roberta Leonardi

发表

Localization and regulation of mouse pantothenate kinase 2

C. Rock, A. Lykidis, Yong-mei Zhang, 2007, FEBS letters.

TSC1 and TSC2 : Tuberous Sclerosis Complex and Its Related Epilepsy Phenotype

C. Di Napoli, A. Polizzi, M. Ruggieri, 2021, Journal of Pediatric Neurology.

Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism

J. Rehg, Yong-mei Zhang, S. Jackowski, 2012, PloS one.

Deregulated coenzyme A, loss of metabolic flexibility and diabetes.

S. Jackowski, Roberta Leonardi, 2014, Biochemical Society transactions.

Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance

C. Rock, S. Jackowski, Roberta Leonardi, 2014, Diabetologia.

Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis*

C. Rock, S. Jackowski, Matthew W. Frank, 2009, The Journal of Biological Chemistry.

Pantothenate Kinase 1 Is Required to Support the Metabolic Transition from the Fed to the Fasted State

C. Rock, J. Rehg, S. Jackowski, 2010, PloS one.

Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver.

P. Fagone, A. Infante, Roberta Leonardi, 2019, Journal of lipid research.

SYNGAP1 and Its Related Epileptic Syndromes

R. Falsaperla, A. Zanghì, A. Praticò, 2021, Journal of Pediatric Neurology.

Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine

C. Rock, Yong-mei Zhang, S. Jackowski, 2007, Proceedings of the National Academy of Sciences.

Thiazole Synthase from Escherichia coli

P. Roach, S. Fairhurst, D. Lowe, 2007, Journal of Biological Chemistry.

Thiamine Biosynthesis in Escherichia coli

P. Roach, Roberta Leonardi, 2004, Journal of Biological Chemistry.

Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex

P. Roach, S. Fairhurst, M. Kriek, 2003, FEBS letters.

The PanK2 Genes of Mouse and Human Specify Proteins with DistinctSubcellular Locations

C. Rock, O. Ilkayeva, C. Newgard, 2007 .

The PanK 2 Genes of Mouse and Human Specify Proteins 1 with Distinct Subcellular Locations 2 3

C. Newgard, J. Bain, Yong-mei Zhang, 2007 .

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria.

C. Rock, V. Luna, Richard E. Lee, 2012, Bioorganic & medicinal chemistry.

Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice

P. Fagone, J. Rehg, J. Gray, 2015, PloS one.

A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases

Asli N. Goktug, C. Rock, Taosheng Chen, 2015, Journal of medicinal chemistry.

NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet

Quincy A. Hathaway, J. A. King, Q. Hathaway, 2022, The Journal of biological chemistry.

The Spectrum of KCNQ2- and KCNQ3-Related Epilepsy

R. Falsaperla, A. Praticò, Giulia Salomone, 2021, Journal of Pediatric Neurology.

Coenzyme A: back in action.

C. Rock, Yong-mei Zhang, S. Jackowski, 2005, Progress in lipid research.

Biosynthesis of Pantothenic Acid and Coenzyme A

S. Jackowski, Roberta Leonardi, 2007, EcoSal Plus.

Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.

P. Naquet, Roberta Leonardi, E. Kerr, 2020, Progress in lipid research.

Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria

Roberta Leonardi, Stephanie A. Shumar, E. Kerr, 2019, FEBS letters.

Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform

W. Geldenhuys, P. Fagone, S. Gabelli, 2018, The Journal of Biological Chemistry.

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.

C. Rock, K. Hevener, Yong-mei Zhang, 2006, Bioorganic & medicinal chemistry.

A Pantothenate Kinase from Staphylococcus aureus Refractory to Feedback Regulation by Coenzyme A*

C. Rock, Yong-mei Zhang, S. Jackowski, 2005, Journal of Biological Chemistry.

Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.

Roberta Leonardi, N. Nicely, S. Jackowski, 2007, Biochemistry.

Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation*

C. Rock, C. Subramanian, S. Jackowski, 2012, The Journal of Biological Chemistry.

Compartmentalization of Mammalian Pantothenate Kinases

S. Jackowski, Roberta Leonardi, Matthew R. Garcia, 2012, PloS one.

The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis

Kezhong Zhang, J. Malhotra, S. Jackowski, 2011, EMBO Journal.

Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway

N. Chandel, P. Bommi, Shengping Huang, 2021, Cell reports.

Pantothenate Kinase from the Thermoacidophilic Archaeon Picrophilus torridus

S. Jackowski, H. Tamaki, S. Hanada, 2009, Journal of bacteriology.

Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.

P. Stoilov, C. Rock, J. Rehg, 2017, Molecular genetics and metabolism.

Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver[S]

P. Fagone, A. Infante, Roberta Leonardi, 2019, Journal of Lipid Research.

Real‐world treatment patterns and outcomes using terlipressin in 203 patients with the hepatorenal syndrome

S. Corman, K. Moore, K. Jamil, 2020, Alimentary pharmacology & therapeutics.

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

C. Rock, Taosheng Chen, Yong-mei Zhang, 2010, Chemistry & biology.

Crystal Structures of Human Pantothenate Kinases

C. Rock, M. Vedadi, Yong-mei Zhang, 2007, Journal of Biological Chemistry.

Acyl-CoA thioesterase-2 facilitates β-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner

R. Vadigepalli, M. Murgia, C. Mesaros, 2023, bioRxiv.

A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis

M. Mori, S. Jakobsen, M. Vendelbo, 2023, Research square.

Supplemental Data Prokaryotic Type II and Type III Pantothenate Kinases : The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties

C. Rock, Yong-mei Zhang, S. White, 2006 .