J. A. García-Horsman

发表

Proton transfer in cytochrome bo3 ubiquinol oxidase of Escherichia coli: second-site mutations in subunit I that restore proton pumping in the mutant Asp135-->Asn.

R. Gennis, A. Puustinen, M. Wikström, 1995, Biochemistry.

Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells

J. Tenorio-Laranga, K. Puttonen, M. Forsberg, 2011, Neurosignals.

The superfamily of heme-copper respiratory oxidases

B. Barquera, R. Gennis, J. Ma, 1994, Journal of bacteriology.

d-Amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice

M. Karayiorgou, J. Gogos, M. Huotari, 2004, Psychopharmacology.

On the role of prolyl oligopeptidase in health and disease

J. A. García-Horsman, J. Venäläinen, P. Männistö, 2007, Neuropeptides.

Characterization of membrane‐bound prolyl endopeptidase from brain

J. Tenorio-Laranga, J. A. García-Horsman, J. Venäläinen, 2008, The FEBS journal.

Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney.

J. Tenorio-Laranga, P. Van der Veken, M. Storvik, 2012, Biochimie.

A novel cytochrome c oxidase from Rhodobacter sphaeroides that lacks CuA.

R. Gennis, E. Berry, J. Shapleigh, 1994, Biochemistry.

Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo.

Erik A. A. Wallén, M. Raki, M. Sarparanta, 2014, European journal of medicinal chemistry.

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

V. Felipo, J. Tenorio-Laranga, C. Montoliu, 2015, Journal of Neuroinflammation.

The role of prolyl oligopeptidase, understanding the puzzle

J. A. García-Horsman, 2020, Annals of translational medicine.

Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?

J. A. García-Horsman, P. Männistö, 2017, Front. Aging Neurosci..

Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research.

J. Tenorio-Laranga, M. Morawski, S. Roßner, 2011, CNS & neurological disorders drug targets.

Hunting for peptide substrates of prolyl oligopeptidase: classical versus non-classical bioactive peptides.

J. Tenorio-Laranga, J. A. García-Horsman, P. Männistö, 2011, CNS & neurological disorders drug targets.

Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders.

J. A. García-Horsman, Aaro J. Jalkanen, J. Venäläinen, 2007, Drug news & perspectives.

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues

T. Myöhänen, M. Piltonen, J. A. García-Horsman, 2008, Histochemistry and Cell Biology.

Purification and characterization of two‐subunit cytochrome aa3 from Bacillus cereus

B. Barquera, D. González-Halphen, J. A. García-Horsman, 1991, Molecular microbiology.

The highly conserved methionine of subunit I of the heme‐copper oxidases is not at the heme‐copper dinuclear center: Mutagenesis of M110 in subunit I of cytochrome bo 3‐type ubiquinol oxidase from Escherichia coli

R. Gennis, J. O. Alben, L. Lemieux, 1995, FEBS letters.

Distribution of Immunoreactive Prolyl Oligopeptidase in Human and Rat Brain

R. Miettinen, E. Tupala, T. Myöhänen, 2007, Neurochemical Research.

Issues About the Physiological Functions of Prolyl Oligopeptidase Based on Its Discordant Spatial Association With Substrates and Inconsistencies Among mRNA, Protein Levels, and Enzymatic Activity

J. Tenorio-Laranga, T. Myöhänen, J. A. García-Horsman, 2009, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Demonstration by FTIR that the bo-type ubiquinol oxidase of Escherichia coli contains a heme-copper binuclear center similar to that in cytochrome c oxidase and that proper assembly of the binuclear center requires the cyoE gene product.

R. Gennis, J. O. Alben, L. Lemieux, 1992, Biochemistry.

Two different aa3-type cytochromes can be purified from the bacterium Bacillus cereus.

B. Barquera, J. A. García-Horsman, J. Escamilla, 1991, European journal of biochemistry.

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

T. Myöhänen, M. Piltonen, J. A. García-Horsman, 2008, The Journal of comparative neurology.

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease

K. Kaukinen, I. Korponay-Szabó, M. Mäki, 2007, Scandinavian journal of gastroenterology.

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

Erik A. A. Wallén, J. Gynther, M. Forsberg, 2006, Biochemical pharmacology.

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.

Erik A. A. Wallén, J. Gynther, R. Juvonen, 2004, The Biochemical journal.

Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.

J. Tenorio-Laranga, M. Valero, J. A. García-Horsman, 2009, Analytical biochemistry.

Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome.

J. Tenorio-Laranga, I. Elovaara, L. Airas, 2013, Biochemical pharmacology.

The cbb3-type cytochrome c oxidase from Rhodobacter sphaeroides, a proton-pumping heme-copper oxidase.

B. Barquera, R. Gennis, M. Wikström, 1998, Biochimica et biophysica acta.

Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice

H. Rauvala, A. Tammimäki, N. Kulesskaya, 2010, Psychopharmacology.

Anticholinergic Drug Use, Serum Anticholinergic Activity, and Adverse Drug Events Among Older People: A Population-Based Study

R. Huupponen, S. Hartikainen, P. Lampela, 2013, Drugs & Aging.

Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.

M. Karayiorgou, J. Gogos, J. Tenorio-Laranga, 2009, Biochemical pharmacology.

L-Dopa-induced desensitization depends on 5-hydroxytryptamine imbalance in hemiparkinsonian rats

M. Piltonen, T. Kääriäinen, J. A. García-Horsman, 2009, Neuroreport.

Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral nigral lesions.

M. Huotari, M. Piltonen, T. Kääriäinen, 2008, Basic & clinical pharmacology & toxicology.

Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume

M. Morawski, V. Võikar, S. Roßner, 2016, European Neuropsychopharmacology.

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

K. Kaukinen, I. Korponay-Szabó, M. Mäki, 2011, Clinical and experimental immunology.

A prolyl oligopeptidase inhibitor, KYP‐2047, reduces α‐synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

V. Baekelandt, A. Lambeir, R. Van Elzen, 2012, British journal of pharmacology.