X. Zhuo

发表

The Pneumotoxin 3-Methylindole Is a Substrate and a Mechanism-Based Inactivator of CYP2A13, a Human Cytochrome P450 Enzyme Preferentially Expressed in the Respiratory Tract

W. Humphreys, Y. Shu, D. G. Morgan, 2009, Drug Metabolism and Disposition.

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

A. Mathur, J. Cutrone, N. Meanwell, 2017, Bioorganic & medicinal chemistry letters.

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

J. Macor, A. Mathur, M. Ahlijanian, 2019, ACS medicinal chemistry letters.

Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice.

L. Kaminsky, D. Spink, J. Gu, 1999, The Journal of pharmacology and experimental therapeutics.

Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.

M. D. Hill, J. Macor, T. Molski, 2016, ACS medicinal chemistry letters.

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Y. Shu, N. Meanwell, K. Yeung, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

J. Macor, A. Mathur, B. Srikumar, 2018, ACS medicinal chemistry letters.

Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane

Joseph L. Cantone, D. Drexler, J. Leet, 2016, Drug Metabolism and Disposition.

Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.

J. Krupinski, A. Azzará, Gary G Cao, 2021, ACS medicinal chemistry letters.

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.

N. Meanwell, J. Lemm, K. Yeung, 2017, ACS medicinal chemistry letters.

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.

B. Beno, K. Kish, S. Sheriff, 2017, MedChemComm.

A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.

Vijay T. Ahuja, J. Macor, Y. Shu, 2009, Journal of medicinal chemistry.

5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.

J. Macor, T. Molski, R. Olson, 2010, Bioorganic & medicinal chemistry letters.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

Anna L. Blobaum, J. Macor, C. Lindsley, 2016, ACS chemical neuroscience.

Regulation of cytochrome P450 gene expression in the olfactory mucosa.

Xinxin Ding, M. Genter, Jun Gu, 2004, Chemico-biological interactions.

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.

Y. Shu, N. Meanwell, Benjamin M. Johnson, 2020, Journal of medicinal chemistry.

Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.

Ian A Blair, C. Felix, I. Blair, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Mouse cyp2g1 gene: promoter structure and tissue-specific expression of a cyp2g1-lacz fusion gene in transgenic mice.

P. Swiatek, J. Schwob, X. Ding, 2001, Archives of biochemistry and biophysics.

Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.

F. Gonzalez, X. Ding, X. Zhuo, 1996, Molecular pharmacology.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Yue-Zhong Shu, Y. Shu, L. Snyder, 2015, Drug Metabolism and Disposition.

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Qi Gao, Min Gao, Steven Sheriff, 2017, Journal of medicinal chemistry.

Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model

W. Humphreys, Y. Shu, Xinxin Ding, 2010, Journal of Pharmacology and Experimental Therapeutics.

Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression

P. Swiatek, H. Cui, Qing-Yu Zhang, 2004, Journal of Pharmacology and Experimental Therapeutics.

Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.

S. E. Kiefer, J. Krupinski, Srinivas Cheruku, 2022, Journal of medicinal chemistry.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

J. Macor, M. Ahlijanian, Joseph L. Cantone, 2014, International journal of Alzheimer's disease.

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

H. Soares, J. Macor, M. Ahlijanian, 2016, The Journal of Pharmacology and Experimental Therapeutics.

NADPH- and hydroperoxide-supported 17β-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1

J. Gierthy, D. Spink, Xinxin Ding, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5 -null Mouse Model

W. Humphreys, Y. Shu, Xinxin Ding, 2009 .

Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.

P. Swiatek, H. Cui, Qing-Yu Zhang, 2005, Biochemical and biophysical research communications.

Conditional knockout of the mouse NADPH‐cytochrome p450 reductase gene

P. Swiatek, Qing-Yu Zhang, Y. Weng, 2003, Genesis.

Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.

W. Humphreys, Y. Shu, Weiping Zhao, 2009, Chemico-biological interactions.

Comparative Biotransformation of Pyrazinone-Containing Corticotropin-Releasing Factor Receptor-1 Antagonists: Minimizing the Reactive Metabolite Formation

Vijay T. Ahuja, Yue-Zhong Shu, Harvey Wong, 2010, Drug Metabolism and Disposition.

Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.

J. Macor, Amy Easton, Anand Balakrishnan, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of Functionalized Derivatives of the Gamma-Secretase Modulator BMS-932481 and Identification of its Major Metabolite.

Antonio Ramirez, J. Macor, M. Ahlijanian, 2020, Bioorganic & medicinal chemistry letters.

Comparative Biotransformation of Pyrazinone-Containing Corticotropin-Releasing Factor Receptor-1 Antagonists: Minimizing the Reactive Metabolite Formation

Vijay T. Ahuja, J. Macor, J. Leet, 2010, Drug Metabolism and Disposition.

Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.

Joseph Payne, Vijay T. Ahuja, Yue-Zhong Shu, 2009, Journal of medicinal chemistry.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Y. Shu, L. Snyder, Benjamin M. Johnson, 2015, Drug Metabolism and Disposition.

COMPARATIVE BIOTRANSFORMATION OF PYRAZINONE-CONTAINING CORTICOTROPIN-RELEASING FACTOR RECEPTOR-1 (CRF-R1) ANTAGONISTS: MINIMIZING THE REACTIVE METABOLITE FORMATION

Vijay T. Ahuja, J. Macor, Stella Huang, 2009 .

Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model

Y. Shu, Xinxin Ding, Fang Xie, 2010, Journal of Pharmacology and Experimental Therapeutics.

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Y. Shu, N. Meanwell, K. Yeung, 2018, Xenobiotica; the fate of foreign compounds in biological systems.