J. Dawson

发表

Metalloproteinases Transcription of Matrix Rheumatoid Arthritis and Induces Expression Is Up-Regulated in Serum Amyloid A (apoSAA)

R. Urfer, L. Boes, F. Freuler, 2010 .

Serum Amyloid A (apoSAA) Expression Is Up-Regulated in Rheumatoid Arthritis and Induces Transcription of Matrix Metalloproteinases

A. Robeva, R. Urfer, L. Boes, 2001, The Journal of Immunology.

Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease

Paul J. Groot-Kormelink, Daniel R. Beisner, M. Cooke, 2015, PloS one.

Hemoglobinase Activity of the Lysine Gingipain Protease (Kgp) of Porphyromonas gingivalis W83

D. Muddiman, F. L. Macrina, J. Hannis, 1999, Journal of bacteriology.

Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice

P. V. Van Veldhoven, B. Kinzel, B. Zemann, 2008, The Journal of Immunology.

Ceramide Kinase-Deficient Mice in Streptococcus pneumoniae Response to Neutropenia with Impaired Immune

Reichel, B. Kinzel, B. Zemann, 2008 .

CYCLOSPORIN A INHIBITS THE IN VIVO PRODUCTION OF INTERLEUKIN-1β AND TUMOUR NECROSIS FACTOR α, BUT NOT INTERLEUKIN-6, BY A T-CELL-INDEPENDENT MECHANISM

U. Hurtenbach, J. Dawson, A. MacKenzie, 1996 .

Targeting interleukin-4 to the arthritic joint.

L. Meinel, K. Seuwen, Hilmar Ebersbach, 2020, Journal of controlled release : official journal of the Controlled Release Society.

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.

H. Gram, J. Kovarik, C. Burkhart, 2009, Arthritis and rheumatism.

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

T. Junt, Juan Zhang, J. Carballido, 2016, The Journal of experimental medicine.

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

R. Hersperger, N. Beckmann, H. Otto, 2016, PloS one.

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

R. Wolf, A. Hofmann, C. Bergsdorf, 2017, Scientific Reports.

Angiogenesis inhibition by the novel VEGF receptor tyrosine kinase inhibitor, PTK787/ZK222584, causes significant anti-arthritic effects in models of rheumatoid arthritis

K. Grosios, J. Dawson, J. Wood, 2004, Inflammation Research.

Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging

S. Hatakeyama, N. Accart, N. Beckmann, 2021, Scientific reports.

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.

E. Hirsch, M. Wymann, R. Marone, 2013, The Journal of allergy and clinical immunology.

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants

K. Mertz, T. Junt, P. Loetscher, 2022, JCI insight.

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

T. Mak, K. McCoy, D. Patel, 2015, The Journal of Immunology.

Effector T and B Cell Responses Leading to Results in Unbalanced Regulatory and Deficiency of MALT1 Paracaspase Activity

T. Mak, K. McCoy, D. Patel, 2015 .

Nondepleting anti-CD4 and soluble interleukin-1 receptor prevent autoimmune destruction of syngeneic islet grafts in diabetic NOD mice1

A. Cooke, J. Phillips, F. Nicoletti, 2002, Transplantation.

Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.

R. Hersperger, A. Vulpetti, B. Cenni, 2019, ACS medicinal chemistry letters.

Original Research Papers Angiogenesis inhibition by the novel VEGF receptor tyrosine kinase inhibitor, PTK787/ZK222584, causes significant anti-arthritic effects in models of rheumatoid arthritis

K. Grosios, J. Dawson, A. Platform, 2004 .

Cyclosporin A inhibits the in vivo production of interleukin-1beta and tumour necrosis factor alpha, but not interleukin-6, by a T-cell-independent mechanism.

U. Hurtenbach, J. Dawson, A. MacKenzie, 1996, Cytokine.

Targeting monocyte chemoattractant protein-1 signalling in disease

C. Wiessner, A. Mir, J. Dawson, 2003, Expert opinion on therapeutic targets.

Could rheumatoid arthritis have an infectious aetiology

J. Dawson, M. Roland, 2005 .

GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice

R. Kreutzer, G. Wieczorek, N. Carballido‐Perrig, 2016, Allergy.

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

K. Seuwen, P. Loetscher, Daniela Gabriel, 2017, Bioorganic & medicinal chemistry.

Improved Lymphocyte Function-associated Antigen-1 (LFA-1) Inhibition by Statin Derivatives

J. Kallen, G. Weitz-Schmidt, J. Dawson, 2004, Journal of Biological Chemistry.

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.

S. Hintermann, D. Theil, D. Patel, 2017, JCI insight.

Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors.

S. Hintermann, P. Ertl, M. Streiff, 2019, Journal of medicinal chemistry.

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.

S. Hintermann, R. Wolf, A. Vulpetti, 2018, Journal of medicinal chemistry.

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.

M. Kroemer, C. Scheufler, J. Velcicky, 2010, Bioorganic & medicinal chemistry letters.

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.

E. G. Funhoff, A. Vulpetti, B. Nuesslein-Hildesheim, 2020, Journal of medicinal chemistry.

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo

S. Hintermann, K. Kaupmann, J. Kallen, 2017, PloS one.

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia

Jeffrey A. Porter, T. Bouwmeester, K. Mansfield, 2017, Science Signaling.

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors

R. Wolf, A. Hofmann, C. Bergsdorf, 2017, Scientific Reports.

The monoclonal antibody MEL‐14 can block lymphocyte migration into a site ofchronic inflammation

J. Edwards, P. Lees, J. Dawson, 1992, European journal of immunology.

Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat

S. Bevan, L. Urbán, J. Courade, 2004, Pain.

Effects of soluble interleukin-1 type II receptor on rabbit antigen-induced arthritis: clinical, biochemical and histological assessment.

P. Ramage, D. Cheneval, J. Dawson, 1999, Rheumatology.

Macrophage infiltration into the rat knee detected by MRI in a model of antigen‐induced arthritis

N. Beckmann, J. Dawson, P. Engelhardt, 2003, Magnetic resonance in medicine.

Fluorescent nanoprobes as a biomarker for increased vascular permeability: implications in diagnosis and treatment of cancer and inflammation.

H. Gremlich, R. Kneuer, Britto S. Sandanaraj, 2010, Bioconjugate chemistry.

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

K. Azzaoui, R. Wolf, P. Loetscher, 2021, Journal of medicinal chemistry.

Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase‐2

L. Urbán, R. Fujimoto, Xiaoli Zhang, 2005, British journal of pharmacology.

Synthesis and Biological Evaluation of New Triazolo‐ and Imidazolopyridine RORγt Inverse Agonists

S. Hintermann, A. Vulpetti, K. Kaupmann, 2016, ChemMedChem.

Preclinical pharmacology of robenacoxib: a novel selective inhibitor of cyclooxygenase-2.

P. Toutain, P. Lees, R. Fujimoto, 2009, Journal of veterinary pharmacology and therapeutics.

Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor.

R. Hersperger, T. Mueller, J. Dawson, 2002, Bioorganic & medicinal chemistry letters.

The Arabidopsis MALE STERILITY1 (MS1) gene is a transcriptional regulator of male gametogenesis, with homology to the PHD-finger family of transcription factors.

P. Tighe, R. Swarup, P. Tighe, 2001, The Plant journal : for cell and molecular biology.

Non-Invasive Imaging Demonstrates Clinical Features of Ankylosing Spondylitis in a Rat Adjuvant Model: a Case Study

F. Kolbinger, N. Accart, N. Beckmann, 2016, European journal of histochemistry : EJH.