J. Rosen

发表

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor

P. Lamb, H. Seidel, S. Tian, 1994 .

Interleukin-3/erythropoietin fusion proteins: in vitro effects on hematopoietic cells.

M. Vadas, P. Quesenberry, M. McMahon, 1993, Experimental hematology.

Peptide Binding Identifies an ERα Conformation That Generates Selective Activity in Multiple In Vitro Assays

A. Negro-Vilar, C. Larson, H. Seidel, 2005, Journal of biomolecular screening.

Biochemical approaches to discovering modulators of the JAK-STAT pathway

P. Lamb, P. Tapley, J. Rosen, 1998 .

Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.

J. Luengo, R. Shah, K. Duffy, 2001, Journal of medicinal chemistry.

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.

J. Luengo, S. Miller, L. Zhang, 2002, Journal of medicinal chemistry.

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

J. Luengo, S. Miller, L. Zhang, 2002, Journal of medicinal chemistry.

Discovery of a new class of glucosylceramide synthase inhibitors.

J. Nuss, S. Richards, P. Lamb, 2011, Bioorganic & medicinal chemistry letters.

Discovery and characterization of an inhibitor of glucosylceramide synthase.

K. Ogilvie, J. Nuss, S. Richards, 2012, Journal of medicinal chemistry.

A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor [see commetns].

J G Gleason, J. Luengo, J. Gleason, 1998, Science.

Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.

S. Miller, K. Duffy, P. Lamb, 2005, Experimental hematology.

Selective Binding and Oligomerization of the Murine Granulocyte Colony-stimulating Factor Receptor by a Low Molecular Weight, Nonpeptidyl Ligand*

Michael L Doyle, John Trill, Ruth Lehr, 2003, The Journal of Biological Chemistry.

Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

H. Seidel, Lawrence H. Milocco, Jennifer A. Haslam, 1999, Molecular and Cellular Biology.

Regulatory Function Insights into STAT Activation and Gene Design of Conditionally Active STATs :

H. Seidel, J. Rosen, L. Milocco, 1999 .

Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist

J. Luengo, S. Miller, K. Duffy, 2009, Stem cells.

Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma

S. Gottschalk, N. Rainusso, N. Ahmed, 2011, Cancer Gene Therapy.

Discovery of SB-497115, a Small-Molecule Thrombopoietin (TPO) Receptor Agonist for the Treatment of Thrombocytopenia.

Stephen G. Miller, Kevin J. Duffy, J. Luengo, 2004 .

Biological Activity and Selectivity for Tpo Receptor of the Orally Bioavailable, Small Molecule Tpo Receptor Agonist, SB-497115.

J. Luengo, S. Miller, K. Duffy, 2004 .

Species Specificity and Receptor Domain Interaction of a Small Molecule TPO Receptor Agonist.

J. Luengo, S. Miller, K. Duffy, 2004 .

Pharmaceutical intervention in the JAK/STAT signaling pathway

P. Lamb, H. Seidel, J. Rosen, 2000, Oncogene.

In vitro and in vivo biology of a small molecular weight Tpo receptor agonist, SB-497115

J. Luengo, K. Duffy, R. Keenan, 2005 .

Chapter 27. The Role of JAKs and STATs in Transcriptional Regulation by Cytokines

P. Lamb, H. Seidel, R. Stein, 1996 .

Drug Discovery Approaches Targeting the JAK/STAT Pathway

H. Seidel, J. Rosen, 2003 .

Rapid Activation of the STAT 3 Transcription Factor by Granulocyte Colony-Stimulating Factor

Robert, P. Lamb, H. Seidel, 2002 .

Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes.

P. Lamb, S S Tian, P Tapley, 1996, Blood.

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor.

P. Lamb, H. Seidel, S. Tian, 1994, Blood.

Intracellular receptors and signal transducers and activators of transcription superfamilies: novel targets for small-molecule drug discovery.

R. Stein, A. Nadzan, T. K. Jones, 1995, Journal of medicinal chemistry.

Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice.

L. Shultz, M. Gallina, P. Lamb, 1997, Experimental hematology.

Drug discovery using receptors that modulate gene expression.

P. Lamb, J. Rosen, 1997, Journal of receptor and signal transduction research.