G. Saccomanni

发表

Carbazole-containing arylcarboxamides as BACE1 inhibitors.

S. Moro, J. Mason, A. Bortolato, 2011, Bioorganic & medicinal chemistry letters.

Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells

M. Breschi, S. Fogli, A. Saba, 2016, Nutrition and cancer.

Preliminary Investigation of a Novel 18F Radiopharmaceutical for Imaging CB2 Receptors in a SOD Mouse Model

P. Iozzo, S. Burchielli, Mariarosaria De Simone, 2021, Australian Journal of Chemistry.

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells

V. Manganelli, C. Manera, M. Sorice, 2018, International journal of molecular sciences.

Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2, 3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2, 3-b]pyridine:potential antihypertensive agents - part IX.

A. Martinelli, V. Calderone, P. Nieri, 2000, European journal of medicinal chemistry.

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

S. Sestito, S. Rapposelli, V. Calderone, 2019, European journal of medicinal chemistry.

Taurine in women with a history of gestational diabetes.

G. Seghieri, G. Ghirlanda, F. Franconi, 2007, Diabetes research and clinical practice.

Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors

S. Bertini, C. Manera, R. Ghidoni, 2017, Molecules.

Microfluidic approach for fast labeling optimization and dose-on-demand implementation.

C. Manera, G. Pascali, P. Salvadori, 2010, Nuclear medicine and biology.

Rutin and quercetin content in the forage of common buckwheat as affected by maturity and conservation method.

M. Mariotti, F. Pedonese, F. Fratini, 2017 .

Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

S. Rapposelli, C. Ghelardini, G. Chiellini, 2022, Journal of medicinal chemistry.

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.

S. Fogli, A. Malfitano, V. Di Marzo, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.

G. Gessa, V. Calderone, C. Manera, 2004, Bioorganic & medicinal chemistry.

4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor.

D. Tuscano, C. Martini, S. Bertini, 2002, Farmaco.

A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.

G. Giannaccini, A. Lucacchini, A. Martinelli, 2000, Journal of medicinal chemistry.

Stereoselective synthesis and β-blocking activity of substituted (E)- and (Z)-4(1H)-[1-(3-alkylamino-2-hydroxypropyl)oximino]-2,3-dihydro-1,8-naphthyridine. Potential antihypertensive agents. Part VI.

V. Calderone, C. Manera, C. Mori, 1998 .

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

J. Gertsch, F. Gado, S. Bertini, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

S. Rapposelli, G. Chiellini, R. Pertwee, 2022, Frontiers in Chemistry.

Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.

J. Gertsch, S. Bertini, C. Manera, 2016, European journal of medicinal chemistry.

Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives

M. Vitale, T. Tuccinardi, A. Martinelli, 2013, Journal of Neuroimmune Pharmacology.

Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis

C. Procaccini, G. Matarese, T. Tuccinardi, 2013, PloS one.

Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts Using Multiple Internal Standards and Photo-Diode UV Detection

A. Rossi, G. Giannaccini, A. Lucacchini, 2010 .

Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor.

S. Burchielli, Mariarosaria De Simone, D. Panetta, 2015, Bioorganic & medicinal chemistry letters.

Use of non-azeotropically dried complex in microfluidic radiofluorinations

C. Manera, G. Pascali, P. Salvadori, 2012 .

Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs.

A. Saba, M. Giorgi, C. Manera, 2010, Journal of pharmaceutical and biomedical analysis.

Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.

A. Vannacci, T. Tuccinardi, A. Martinelli, 2006, Journal of medicinal chemistry.

Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase.

J. Gertsch, S. Bertini, C. Manera, 2015, Journal of pharmaceutical and biomedical analysis.

A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.

P. Matarrese, W. Malorni, C. Manera, 2012, Anti-cancer agents in medicinal chemistry.

Pharmacokinetics of Tramadol after Epidural Administration in Horses

M. Giorgi, G. Saccomanni, V. Andreoni, 2010 .

Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity

A. Martinelli, C. Manera, C. Mori, 1997 .

Rutin content in the forage and grain of common buckwheat (Fagopyrum esculentum) as affected by sowing time and irrigation in a Mediterranean environment

M. Mariotti, I. Arduini, M. Macchia, 2020, Crop and Pasture Science.

Synthesis and antiplatelet activity of some 2,7-di(N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives.

F. Franconi, C. Manera, C. Mori, 2001, Farmaco.

Unusual Nitration of Substituted 7-Amino-1,8-naphthyridine in the Synthesis of Compounds with Antiplatelet Activity.

A. Martinelli, C. Manera, C. Mori, 1998 .

Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents — Part VII

V. Calderone, P. Nieri, E. Martinotti, 1998 .

Synthesis and β-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of β3-antagonists

V. Calderone, C. Manera, L. Testai, 2003 .

Synthesis and Antiplatelet Activity of Some 2,7‐Di(N‐cycloamino)‐3‐phenyl‐1,8‐naphthyridine Derivatives.

F. Franconi, C. Manera, C. Mori, 2001 .

Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives.

F. Franconi, C. Manera, C. Mori, 2000, Farmaco.

Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2004, Journal of medicinal chemistry.

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

A. Giordano, T. Tuccinardi, A. Martinelli, 2012, European journal of medicinal chemistry.

Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography

C. Manera, M. Macchia, G. Saccomanni, 2013, Natural product research.

Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives.

C. Manera, C. Mori, M. Badawneh, 1998, Farmaco.

High performance liquid chromatographic determination of thalidomide in patients affected by hepatocellular carcinoma.

C. Jemos, M. Giorgi, C. Manera, 2008, Journal of pharmaceutical and biomedical analysis.

Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer.

S. Fogli, B. Polini, S. Carpi, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Pharmacokinetic and urine profile of tramadol and its major metabolites following oral immediate release capsules administration in dogs

M. Giorgi, B. Łebkowska-Wieruszewska, G. Saccomanni, 2009, Veterinary Research Communications.

Pharmacokinetics of tramadol and its major metabolites following rectal and intravenous administration in dogs

M. Giorgi, G. Saccomanni, S. Del Carlo, 2009, New Zealand veterinary journal.

Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study.

M. Giorgi, C. Kowalski, G. Saccomanni, 2009, Veterinary journal.

Evaluation of tramadol and its main metabolites in horse plasma by high-performance liquid chromatography/fluorescence and liquid chromatography/electrospray ionization tandem mass spectrometry techniques.

M. De Leo, M. Giorgi, C. Manera, 2009, Rapid communications in mass spectrometry : RCM.

Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration

M. Giorgi, C. Manera, G. Soldani, 2007 .

D13 In vitro metabolism of tramadol in horses: preliminary data

M. Giorgi, C. Manera, G. Soldani, 2006 .

Synthesis of variously substituted 1,8-naphthyridine derivatives and evaluation of their antimycobacterial activity.

C. Manera, C. Mori, M. Badawneh, 2002, Il Farmaco.

Synthesis of 3- or 4-phenyl-1,8-naphthyridine derivatives and evaluation of antimycobacterial and antimicrobial activity.

C. Manera, M. Badawneh, G. Saccomanni, 2003, Farmaco.

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.

Ettore Novellino, Luciana Marinelli, Marco Macchia, 2015, European journal of medicinal chemistry.

Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts

S. Rocchiccioli, G. Signore, C. Manera, 2014, Journal of Radioanalytical and Nuclear Chemistry.

Pharmacokinetics of Tramadol and Its Metabolites M1, M2, and M5 in Donkeys after Intravenous and Oral Immediate Release Single-Dose Administration

M. Giorgi, G. Saccomanni, M. Sgorbini, 2009 .

Effect of oral co-administration of frozen-dried grapefruit juice on pharmacokinetics of tramadol in dogs

M. Giorgi, H. Yun, G. Saccomanni, 2011 .

Pharmacokinetics of tramadol and metabolites after injective administrations in dogs.

M. Giorgi, B. Łebkowska-Wieruszewska, G. Saccomanni, 2010, Polish journal of veterinary sciences.

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.

M. Sturlese, S. Moro, S. Rapposelli, 2017, Bioorganic & medicinal chemistry letters.

Biopharmaceutical profile of tramadol in the dog

M. Giorgi, B. Łebkowska-Wieruszewska, G. Saccomanni, 2009, Veterinary Research Communications.

Pharmacokinetic of tramadol and its major metabolites after intravenous and intramuscular injections in alpacas (Vicugna pacos).

M. Giorgi, G. Saccomanni, V. Andreoni, 2010 .

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2016, Journal of medicinal chemistry.

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Brandie M. Ehrmann, V. Di Marzo, A. Ligresti, 2014, Journal of medicinal chemistry.

Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives

M. Vitale, T. Tuccinardi, A. Martinelli, 2013, Journal of Neuroimmune Pharmacology.

Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

S. Sestito, S. Rapposelli, C. Manera, 2022, Pharmaceuticals.

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

M. Cascio, C. Ghelardini, T. Tuccinardi, 2007, Bioorganic & medicinal chemistry letters.

1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

A. Malfitano, V. Di Marzo, A. Ligresti, 2014, European journal of medicinal chemistry.

Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis.

Tiziano Tuccinardi, Adriano Martinelli, Gabriella Ortore, 2006, Journal of medicinal chemistry.

Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.

E. Masini, M. Cascio, T. Tuccinardi, 2009, Journal of medicinal chemistry.

Pharmacokinetics of intravenous and intramuscular parecoxib in healthy Beagles.

M. Giorgi, C. Manera, E. Lavy, 2012, Veterinary journal.

1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.

G. Giannaccini, T. Tuccinardi, A. Martinelli, 2005, Bioorganic & medicinal chemistry letters.

Adenosine receptor modelling. A1/A2a selectivity.

T. Tuccinardi, A. Martinelli, C. Manera, 2006, European journal of medicinal chemistry.

Use of capillary electrophoresis and poly(ethylene oxide) as the coating agent for the determination of substances related to heroin addiction and treatment.

C. Manera, M. Macchia, G. Saccomanni, 2006, Journal of analytical toxicology.

Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells

S. Rapposelli, A. Malfitano, S. di Somma, 2022, Molecules.

Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology

A. Saba, M. Giorgi, C. Manera, 2011, Analytical and bioanalytical chemistry.

Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X.

V. Calderone, C. Manera, L. Testai, 2001, European journal of medicinal chemistry.

Tyrosol-Enriched Tomatoes by Diffusion across the Fruit Peel from a Chitosan Coating: A Proposal of Functional Food

A. Ranieri, D. Monti, A. Castagna, 2021, Foods.