E. Manas

发表

Acylguanidines as small-molecule beta-secretase inhibitors.

M. Malamas, K. Fan, B. Harrison, 2006, Journal of medicinal chemistry.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.

M. Malamas, K. Fan, B. Harrison, 2008, Bioorganic & medicinal chemistry letters.

Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.

Rajiv Chopra, Peter Reinhart, Jim Turner, 2010, Bioorganic & medicinal chemistry letters.

ERβ Ligands. Part 1: The discovery of ERβ selective ligands which embrace the 4-hydroxy-biphenyl template

Eric S Manas, Heather A. Harris, Richard Eric Mewshaw, 2003 .

ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives.

S. T. Cohn, H. Harris, S. Bowen, 2007, Bioorganic & medicinal chemistry letters.

Spontaneous emission and absorption in model aggregates of π-conjugated oligomers

F. Spano, E. Manas, M. McIntire, 1997 .

GRAM: A True Null Model for Relative Binding Affinity Predictions

A. P. Graves, Guanglei Cui, E. Manas, 2019, J. Chem. Inf. Model..

ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.

J. Keith, R. Henderson, H. Harris, 2005, Journal of medicinal chemistry.

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor.

C. Jamieson, D. Somers, V. Patel, 2017, ACS medicinal chemistry letters.

Electronic interactions in metal complexed photoconducting polymers: a ZINDO study

Lin X. Chen, E. Manas, 2000 .

Radiative Decay of Excitons in Model Aggregates of π-Conjugated Oligomers

F. Spano, E. Manas, 1997 .

7-Substituted 2-phenyl-benzofurans as ERβ selective ligands

David H. Kaufman, Rayomand J. Unwalla, Eric S. Manas, 2004 .

Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

A. Robichaud, R. Winneker, E. Koury, 2009, Bioorganic & medicinal chemistry.

Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.

Iwan Gunawan, Eric S Manas, M. Malamas, 2004, Journal of medicinal chemistry.

ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives.

Eric S Manas, An T. Vu, An T Vu, 2005, Bioorganic & medicinal chemistry letters.

ERβ ligands. Part 6 6H -Chromeno [4,3 -b]quinolines as a new series of estrogen receptor β-selective ligands

Rayomand J. Unwalla, Eric S. Manas, An T. Vu, 2007 .

The Effects of Protein Environment on the Low Temperature Electronic Spectroscopy of Cytochrome c and Microperoxidase-11

K. Sharp, J. Vanderkooi, E. Manas, 1999 .

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

M. Jaye, J. Trill, R. Annan, 2009, Bioorganic & medicinal chemistry letters.

Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.

V. Patel, A. Watson, E. Manas, 2017, Organic letters.

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones.

M. Malamas, R. Mcdevitt, H. Harris, 2005, Bioorganic & medicinal chemistry letters.

Horseradish peroxidase monitored by infrared spectroscopy: effect of temperature, substrate and calcium.

J. Vanderkooi, W. W. Wright, E. Manas, 1999, Biochimica et biophysica acta.

Infrared Spectra of Amide Groups in α-Helical Proteins: Evidence for Hydrogen Bonding between Helices and Water

Jane M. Vanderkooi, Eric S. Manas, Wayne W. Wright, 2000 .

Hydrates and Solid-State Reactivity: A Survey of β-Lactam Antibiotics

M. Peterson, O. Almarsson, Magali B. Hickey, 2007 .

Theory of coherent transient spectroscopy in molecular aggregates: The effects of interacting excitons

F. Spano, E. Manas, 1995 .

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Rajiv Chopra, Yun Hu, Eric S. Manas, 2006 .

Structure-based design of estrogen receptor-beta selective ligands.

Eric S Manas, T. Akopian, J. Alvarez, 2004, Journal of the American Chemical Society.

7-Substituted 2-phenyl-benzofurans as ER beta selective ligands.

R. Henderson, H. Harris, M. Collini, 2004, Bioorganic & medicinal chemistry letters.

Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations

M. Nelson, L. Cardon, J. Whittaker, 2011, The Pharmacogenomics Journal.

Identification of novel estrogen receptor α antagonists

Robert Powers, R. Powers, R. Winneker, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Bioorganic & medicinal chemistry letters.

Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods.

Eric S Manas, W. Somers, William S Somers, 2004, Structure.

Nonlinear optical response of cofacial phthalocyanine dimers and trimers

F. Spano, Lin X. Chen, E. Manas, 1997 .

Absorption and spontaneous emission in aggregates of conjugated polymers

F. Spano, E. Manas, 1998 .

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).

C. Murray, Zehong Wan, V. Berdini, 2016, Journal of medicinal chemistry.

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

C. Murray, F. Holding, V. Berdini, 2016, Journal of medicinal chemistry.

SPAM: A Simple Approach for Profiling Bound Water Molecules.

Guanglei Cui, Jason M Swails, Eric S Manas, 2013, Journal of chemical theory and computation.

Collaborating to improve the use of free-energy and other quantitative methods in drug discovery

Herman van Vlijmen, Richard Lewis, Deborah A. Loughney, 2016, Journal of Computer-Aided Molecular Design.

ERbeta ligands. Part 2: Synthesis and structure-activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives.

Eric S Manas, Heather A Harris, Richard E Mewshaw, 2004, Bioorganic & medicinal chemistry.

The Influence of Protein Environment on the Low Temperature Electronic Spectroscopy of Zn-Substituted Cytochrome c

K. Sharp, J. Vanderkooi, J. Friedrich, 2000 .

Modeling the value of predictive affinity scoring in preclinical drug discovery.

Robert Abel, Lingle Wang, Richard A Friesner, 2018, Current opinion in structural biology.

ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

An T Vu, H. Harris, R. Unwalla, 2007, Bioorganic & medicinal chemistry letters.

Thiophene substituted acylguanidines as BACE1 inhibitors.

M. Malamas, A. Robichaud, R. Chopra, 2007, Bioorganic & medicinal chemistry letters.

Critical evaluation of methods to incorporate entropy loss upon binding in high‐throughput docking

Sumeet Salaniwal, Eric S Manas, J. Alvarez, 2006, Proteins.

ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.

H. Harris, E. Manas, R. Edsall, 2003, Bioorganic & medicinal chemistry.

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.

M. Malamas, K. Fan, A. Robichaud, 2010, Bioorganic & medicinal chemistry letters.

Water structure changes induced by hydrophobic and polar solutes revealed by simulations and infrared spectroscopy

K. Sharp, B. Madan, J. Vanderkooi, 2001 .

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

M. Malamas, K. Fan, B. Harrison, 2008 .

Frenkel Biexcitons in 1D J-aggregates

F. Spano, E. Manas, 1995 .