Tom T. Lee

发表

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.

Paul C. Rogers, Cheng-Ying Wu, Bin Zhang, 2021, Cell stem cell.

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Michel Sadelain, Chia-Wei Chang, Sjoukje J. C. van der Stegen, 2019, Blood.

Myogenic Differentiation of Muscular Dystrophy‐Specific Induced Pluripotent Stem Cells for Use in Drug Discovery

Bahram Valamehr, M. Bennett, Ramzey J Abujarour, 2014, Stem cells translational medicine.

Pluripotent stem cell-derived NK cells with high-affinity non-cleavable CD16a mediate improved anti-tumor activity.

Paul C. Rogers, D. Kaufman, Jeffrey S. Miller, 2019, Blood.

Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.

H. Tseng, A. Ribas, Xingzhong Zhao, 2013, Angewandte Chemie.

Highly efficient capture of circulating tumor cells by using nanostructured silicon substrates with integrated chaotic micromixers.

H. Tseng, D. Seligson, Jiaoti Huang, 2011, Angewandte Chemie.

Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

M. Sadelain, V. Alexeeva, Raedun Clarke, 2022, Nature Biomedical Engineering.

iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy

Paul C. Rogers, D. Kaufman, Raedun Clarke, 2020, Science Translational Medicine.

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

U. Höpken, A. Rehm, K. Malmberg, 2022, Nature Communications.

FT576: A Novel Multiplexed Engineered Off-the-Shelf Natural Killer Cell Immunotherapy for the Dual-Targeting of CD38 and Bcma for the Treatment of Multiple Myeloma

U. Höpken, A. Rehm, Bahram Valamehr, 2019, Blood.

Specific Capture and Release of Circulating Tumor Cells Using Aptamer‐Modified Nanosubstrates

Xiaochun Xu, Xiaohong Fang, Shuang Hou, 2013, Advanced materials.

A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer

Shuang Hou, Yong Hou, Huanming Yang, 2015, Oncotarget.

Platform for Induction and Maintenance of Transgene-free hiPSCs Resembling Ground State Pluripotent Stem Cells

Bahram Valamehr, A. Medcalf, F. Vranceanu, 2014, Stem cell reports.

Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics.

Shuang Hou, Tracy Ro, Hsian-Rong Tseng, 2017, ACS nano.

Capture and Stimulated Release of Circulating Tumor Cells on Polymer‐Grafted Silicon Nanostructures

H. Tseng, A. Nakao, S. Hou, 2013, Advanced materials.

High‐Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber‐Embedded Microchip for Whole Exome Sequencing

Xiaohong Fang, Shuang Hou, Hsian-Rong Tseng, 2013, Advanced materials.

The index patient and samples

Huanming Yang, Jun Wang, Xiuqing Zhang, 2015 .

Abstract 3574: Cytokine-autonomous, CAR-directed, off-the-shelf natural killer cells derived from a clonal engineered master pluripotent cell line

D. Kaufman, Bahram Valamehr, S. Mahmood, 2018, Immunology.

Abstract LB-108: Generation of off-the-shelf TCR-less CAR-targeted cytotoxic T cells from renewable pluripotent cells for cancer immunotherapy

M. Sadelain, Raedun Clarke, Eigen R. Peralta, 2018, Immunology.

Anti-NKG2C/IL-15/anti-CD33 Killer Engager Directs Primary and iPSC-derived NKG2C+ NK cells to Specifically Target Myeloid Leukemia.

Jeffrey S. Miller, K. Malmberg, D. Vallera, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Dual-antigen targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia.

Bahram Valamehr, Z. Davis, A. Witty, 2022, Blood.

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Raedun Clarke, J. Bressi, Bahram Valamehr, 2021, Blood.

117 FT536 Path to IND: Ubiquitous targeting of solid tumors with an off-the-shelf, first-of-kind MICA/B-specific CAR-iNK cellular immunotherapy

Shohreh H Sikaroodi, Paul C. Rogers, Raedun Clarke, 2021, Journal for ImmunoTherapy of Cancer.

A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors.

Shohreh H Sikaroodi, K. Wucherpfennig, Tianhao Xu, 2023, Med.

Programming Thermoresponsiveness of NanoVelcro Substrates Enables Effective Purification of Circulating Tumor Cells in Lung Cancer Patients

Shuang Hou, Jin-sil Choi, Hsian-Rong Tseng, 2014, ACS nano.

204 Combining FT536, a pan-tumor targeting CAR NK cell therapy, with CD16 engagers provides a coordinated targeting strategy to overcome tumor heterogeneity

Shohreh H Sikaroodi, Bryan M. Hancock, J. Powderly, 2022, Regular and Young Investigator Award Abstracts.

Abstract 1539: Development of off-the-shelf B7H3 chimeric antigen receptor NK cell therapeutic with broad applicability across many solid tumors

Bahram Valamehr, Z. Davis, S. Gaidarova, 2021, Immunology.

Off-the-Shelf, iPSC-Derived CAR-NK Cells Multiplexed-Engineered for the Avoidance of Allogeneic Host Immune Cell Rejection

K. Malmberg, Q. Hammer, Bahram Valamehr, 2021, Blood.

High‐Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber‐Embedded Microchip for Whole Exome Sequencing

H. Tseng, E. Posadas, X. Fang, 2013, Advanced materials.

Specific Capture and Release of Circulating Tumor Cells Using Aptamer‐Modified Nanosubstrates

H. Tseng, X. Fang, Yunshan Fan, 2013, Advanced materials.

169 Off-the-shelf, engineered iPSC-derived NK cells mediate potent cytotoxic activity against primary glioblastoma cells and promote durable long-term survival in vivo

Paul C. Rogers, Clark C. Chen, M. Ge, 2021, Journal for ImmunoTherapy of Cancer.

Abstract 3576: FT500, an off-the-shelf NK cell cancer immunotherapy derived from a master pluripotent cell line, enhances T-cell activation and recruitment to overcome checkpoint blockade resistance

Paul C. Rogers, Raedun Clarke, M. Ge, 2018, Immunology.