E. Dierks

发表

Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole.

P. Ortiz de Montellano, E. Dierks, S. C. Davis, 1998, Biochemistry.

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

Honglu Zhang, S. Ball, H. Lim, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake

W. Humphreys, Y. Shu, P. Marathe, 2015, Drug Metabolism and Disposition.

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction

Rongan Zhang, M. Bouvier, D. Gordon, 2021, JACC. Basic to translational science.

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

David S. Nirschl, Kimberly A. Foster, David S Nirschl, 2017, Journal of medicinal chemistry.

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.

Michael A. Galella, S. Sheriff, A. Mathur, 2021, Journal of medicinal chemistry.

Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction.

Rongan Zhang, M. Bouvier, C. Sum, 2022, ACS pharmacology & translational science.

Assessment of pre‐operative maropitant citrate use in macaque (Macaca fasicularis & Macaca mulatta) neurosurgical procedures

G. Roble, E. Dierks, J. MacGuire, 2018, Journal of medical primatology.

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.

C. Chu, E. A. Brown, D. Gordon, 2022, Cell metabolism.

Variable forms of soluble guanylyl cyclase: protein-ligand interactions and the issue of activation by carbon monoxide

T. Spiro, J. Burstyn, Songzhou Hu, 1999, JBIC Journal of Biological Inorganic Chemistry.

Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.

R. Campbell, D. Clawson, C. King, 2008, Journal of medicinal chemistry.

Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.

Kimberly A. Foster, C. Chu, A. Mathur, 2021, Journal of medicinal chemistry.

Studies of the heme coordination and ligand binding properties of soluble guanylyl cyclase (sGC): characterization of Fe(II)sGC and Fe(II)sGC(CO) by electronic absorption and magnetic circular dichroism spectroscopies and failure of CO to activate the enzyme.

J. Dawson, J. Burstyn, E. Dierks, 1995, Biochemistry.

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

M. Bouvier, D. Gordon, F. Villarreal, 2019, JACC. Basic to translational science.

1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N-Acetyltransferase

A. D. Rodrigues, P. Marathe, L. Zhang, 2011, Drug Metabolism and Disposition.

Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism.

P. Ortiz de Montellano, J. Halpert, O. Sibbesen, 1998, Drug metabolism and disposition: the biological fate of chemicals.

The Catalytic Site of Cytochrome P4504A11 (CYP4A11) and Its L131F Mutant*

P. D. de Montellano, Zhoupeng Zhang, E. Dierks, 1998, The Journal of Biological Chemistry.

Application of ultrasound‐guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys

Kimberly A. Foster, E. Janovitz, J. Smalley, 2019, Pharmacology research & perspectives.

The deactivation of soluble guanylyl cyclase by redox-active agents.

J. Burstyn, E. Dierks, 1998, Archives of biochemistry and biophysics.

Nitric oxide (NO), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase.

J. Burstyn, E. Dierks, Elizabeth A. Dierks, 1996, Biochemical pharmacology.

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.

Kimberly A. Foster, Michael A. Galella, J. Barrish, 2023, Bioorganic & medicinal chemistry.

Single-species Allometric Scaling: A Strategic Approach to Support Drug Discovery

Dipal M. Patel, E. Dierks, 2018 .

Discovery of Novel Pyridinones as MGAT2 Inhibitors for the Treatment of Metabolic Disorders.

Kimberly A. Foster, C. Chu, A. Mathur, 2023, Bioorganic & Medicinal Chemistry Letters.

Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders.

Lidet K. Negash, Kimberly A. Foster, A. Mathur, 2023, Journal of medicinal chemistry.